Patents by Inventor Sidney D. Nelson

Sidney D. Nelson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Suicide inhibitors of aromatase
    Patent number: 4745109
    Abstract: Thiol-substituted synthetic steriod hormones or androgens having a testosterone ring system backbone are used to inhibit aromatase's catalyzed conversion of C.sub.19 androgens having a A.sup.4,3-ketone group to estrogens in the treatment of estrogen-dependent tumors, such as metastatic breast cancer in postmenopausal females.The compounds have the general formula: ##STR1## wherein R.sub.1 =a thiol, such as --SH or --CH.sub.2 SH, and R.sub.2 =OH or =O. The preferred synthetic hormones are 17.beta.-hydroxy-10.beta.-mercaptoestr-4-en-3-one, 19-mercaptoandrost-4-en-3,17-dione, and 10.beta.-mercaptoandrost-4-en-3,17-dione.
    Type: Grant
    Filed: August 20, 1984
    Date of Patent: May 17, 1988
    Assignee: Washington Research Foundation
    Inventors: Patrick J. Bednarski, David J. Porubek, Sidney D. Nelson