Patents by Inventor Sidney E. Grossberg

Sidney E. Grossberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human virus associated with chronic fatigue immune deficiency syndrome and assay therefore
    Patent number: 5827750
    Abstract: A method for the detection of the presence or absence of antibodies which bind to antigens of an NMA virus indicative of Chronic Fatigue Immune Deficiency Syndrome is disclosed. This method comprises contacting a solution containing antigens of an NMA virus with a biological sample of a patient and detecting the antibody-antigen complexes. Methods for detection of the presence or absence of antigens or nucleic acid sequences specific to an NMA virus are also disclosed. A substantially purified preparation of an NMA virus and a human cell line chronically infected with an NMA virus are also disclosed.
    Type: Grant
    Filed: August 8, 1996
    Date of Patent: October 27, 1998
    Assignee: Medical College of Wisconsin, Inc.
    Inventors: Sidney E. Grossberg, Vladimir M. Kushnaryov, L. William Cashdollar, Donald R. Carrigan, Konstance K. Knox
  • Human virus associated with chronic fatigue immune deficiency syndrome and assay therefore
    Patent number: 5545550
    Abstract: A method for the detection of the presence or absence of antibodies which bind to antigens of an NMA virus Deficiency is disclosed. This method comprises contacting a solution containing antigens of an NMA virus with a biological sample of a patient and detecting the antibody-antigen complexes. Methods for detection of the presence or absence of antigens or nucleic acid sequences specific to an NMA virus are also disclosed. A substantially purified preparation of an NMA virus and a human cell line chronically infected with an NMA virus are also disclosed.
    Type: Grant
    Filed: May 27, 1994
    Date of Patent: August 13, 1996
    Assignee: Medical College of Wisconsin, Inc.
    Inventors: Sidney E. Grossberg, Vladimir M. Kushnaryov, L. William Cashdollar, Donald R. Carrigan, Konstance K. Knox
  • Therapeutic use of clostridium difficile toxin A
    Patent number: 5466672
    Abstract: Methods for treating cancer are described, including methods for treating colon and pancreatic cancer. Bacterial toxins and portions of bacterial toxins are employed as both diagnostic and therapeutic agents.
    Type: Grant
    Filed: April 8, 1993
    Date of Patent: November 14, 1995
    Assignee: Ophidian Pharmaceuticals, Inc.
    Inventors: Vladimir M. Kushnaryov, Philip N. Redlich, Sidney E. Grossberg, J. James Sedmak
  • Interferon stabilization
    Patent number: 4252791
    Abstract: The loss of biological activity of interferons is prevented or reduced by the addition of soluble lanthanide or calcium salts.
    Type: Grant
    Filed: October 19, 1979
    Date of Patent: February 24, 1981
    Assignee: The Medical College of Wisconsin, Inc.
    Inventors: Sidney E. Grossberg, Joseph J. Sedmak
  • Assay for proteins and polypeptides
    Patent number: 4219337
    Abstract: An assay for proteins or polypeptides in solution using a reagent of Coomassie Brilliant Blue G250 dye in perchloric or hydrochloric acid. Upon mixture of the acidic reagent with a protein sample, the dye couples with the protein and undergoes a color change, following which the absorbance of the mixture can be measured to provide a quantitative analysis for the protein in the sample; the same procedure may be used for sample solutions containing polypeptides. Proteins and polypeptides with molecular weights above about 2000-3000 may be assayed.
    Type: Grant
    Filed: April 27, 1978
    Date of Patent: August 26, 1980
    Assignee: The Medical College of Wisconsin
    Inventors: Sidney E. Grossberg, Joseph J. Sedmak