Patents by Inventor Sidney H. Golub

Sidney H. Golub has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DNA's encoding natural killer cell enhancing factor
    Patent number: 5610286
    Abstract: Recombinant DNA molecules comprising a DNA sequence encoding either NKEF (Natural Killer Enhancing Factor) A or B or their amino acid sequence variants. Essentially pure natural killer enhancing factor comprising the amino acid sequence of NKEF A or B or their amino acid sequence variants. Compositions of matter for use in enhancing the activity of natural killer cells; the composition comprising an anchor moiety to which is linked either NKEF A or B or their amino acid sequence variants. Methods for enhancing the in vivo activity of natural killer cells; the methods comprising introducing in vivo a sufficient amount of either NKEF A or B or their amino acid sequence variants linked to an anchor moiety. In a method for inducing leukocyte activation and proliferation wherein the leukocytes are treated with a cytokine the improvement comprising treating the leukocytes with the cytokine in the presence of NKEF A or B or their amino acid sequence variants.
    Type: Grant
    Filed: August 31, 1994
    Date of Patent: March 11, 1997
    Assignee: The Regents Of The University Of California
    Inventors: Hungyi Shau, Sidney H. Golub
  • Natural killer cell enhancing factor
    Patent number: 5250295
    Abstract: A factor (NKEF) for use in enhancing the activity of natural killer cells both in vivo and in vitro. NKEF is a soluble red blood cell cytosol protein having a molecular mass of between about 300 and 400 kilodaltons as determined by gel filtration high pressure liquid chromatography and an apparent molecular weight of about 48 kilodaltons as determined by non-reducing SDS-PAGE.
    Type: Grant
    Filed: November 4, 1991
    Date of Patent: October 5, 1993
    Assignee: The Regents of the Univ. of California
    Inventors: Hungyi Shau, Sidney H. Golub