Patents by Inventor Sidney Hecht

Sidney Hecht has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 1H-pyrrolo [2, 3 -B] pyridine derivatives and their use as radical quenchers
    Patent number: 9440967
    Abstract: The present disclosure provides biologically active compounds of formula (I): and pharmaceutically acceptable salts thereof, compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.
    Type: Grant
    Filed: February 11, 2013
    Date of Patent: September 13, 2016
    Assignee: Arizona Board of Regents on Behalf of Arizona State University
    Inventors: Sidney Hecht, Xiaoqing Cai, Omar Khdour, Jose I. Armendariz Guajardo
  • Multifunctional radical quenchers for the treatment of mitochondrial dysfunction
    Patent number: 9388163
    Abstract: The present disclosure provides methods for identifying therapeutic agents that are multifunctional radical quenchers. It also provides compounds of formula: and pharmaceutically acceptable salts thereof, compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.
    Type: Grant
    Filed: June 5, 2015
    Date of Patent: July 12, 2016
    Assignee: Arizona Board of Regents, a Body Corporate of the State of Arizona, Acting for and on Behalf of Arizona State University
    Inventors: Sidney Hecht, Omar Khdour, Sandipan Roy Chowdhury, Poulami Talukder
  • Multifunctional radical quenchers for the treatment of mitochondrial dysfunction
    Patent number: 9334250
    Abstract: The present disclosure provides compounds of formula (I): compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.
    Type: Grant
    Filed: October 2, 2013
    Date of Patent: May 10, 2016
    Assignee: Arizona Board of Regents, A Body Corporate of the State of Arizona Acting For and on Behalf of Arizona State University
    Inventors: Sandipan Roy Chowdhury, Omar Khdour, Sidney Hecht
  • SUGAR-LINKER-DRUG CONJUGATES
    Publication number: 20160045611
    Abstract: The present disclosure relates to sugar-linker-drug conjugates, of the formula [A-B-]n-L-D, wherein A is a saccharide; B is a spacer, n is an integer selected from 1 to 3; L is a linker group and D is a drug having a chemically reactive functional group selected from the group consisting of a primary or secondary amine, hydroxyl, sulfhydryl, carboxyl, aldehyde and ketone. Pharmaceutical compositions comprising the conjugates and methods of using them are also provided.
    Type: Application
    Filed: March 14, 2014
    Publication date: February 18, 2016
    Inventors: Sidney Hecht, Rakesh Paul, Chenhong Tang, Manikandadas Mathilakathu Madathil, Chandrabali Bhattacharya
  • SACCHARIDE CONJUGATES
    Publication number: 20160038615
    Abstract: This invention relates to compounds comprising a saccharide conjugated to an imaging agent or a reporter group, compositions comprising them and methods of using them. Specifically BLM-disaccharide and BLM-monosaccharide conjugates containing different linker groups and an imaging agent or a reporter group are provided for the targeting and imaging of tumors.
    Type: Application
    Filed: March 14, 2014
    Publication date: February 11, 2016
    Inventors: Sidney Hecht, Manikandadas Mathilakathu Madathil, Chandrabali Bhattacharya, Trevor Bozeman, Rakesh Paul, Zhiqiang Yu, Michael J. Rishel
  • MULTIFUNCTIONAL RADICAL QUENCHERS
    Publication number: 20150274628
    Abstract: The invention provides a compound of formula (I): [insert formula (I)] wherein X, Y, and R1-R4 have any of the values defined in the specification, and salts thereof, as well as compositions comprising the compounds or salts. The compounds are useful for treating diseases associated with impaired mitochondrial function in an animal.
    Type: Application
    Filed: October 10, 2013
    Publication date: October 1, 2015
    Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
    Inventors: Manikandadas Mathilakathu Madathil, Omar Khdour, Sidney Hecht
  • Multifunctional Radical Quenchers For The Treatment Of Mitochondrial Dysfunction
    Publication number: 20150266851
    Abstract: The present disclosure provides methods for identifying therapeutic agents that are multifunctional radical quenchers. It also provides compounds of formula (I), (II), or (II-A): and pharmaceutically acceptable salts thereof, compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.
    Type: Application
    Filed: June 5, 2015
    Publication date: September 24, 2015
    Inventors: Sidney Hecht, Omar Khdour, Sandipan Roy Chowdhury, Poulami Talukder
  • Multifunctional Radical Quenchers for the Treatment of Mitochondrial Dysfunction
    Publication number: 20150259309
    Abstract: The present disclosure provides compounds of formula (I): compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.
    Type: Application
    Filed: October 2, 2013
    Publication date: September 17, 2015
    Inventors: Sandipan Roy Chowdhury, Omar Khdour, Sidney Hecht
  • Multifunctional radical quenchers for the treatment of mitochondrial dysfunction
    Patent number: 9102626
    Abstract: The present disclosure provides methods for identifying therapeutic agents that are multifunctional radical quenchers. It also provides compounds of formula (I), (II), or (II-A): and pharmaceutically acceptable salts thereof, compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.
    Type: Grant
    Filed: April 4, 2012
    Date of Patent: August 11, 2015
    Assignee: Arizona Board of Regents, a Body Corporate of the State of Arizona
    Inventors: Sidney Hecht, Omar Khdour, Sandipan Roy Chowdhury, Poulami Talukder
  • Multifunctional radical quenchers and their uses
    Patent number: 8952025
    Abstract: The present disclosure provides biologically active compounds of formula (I): and pharmaceutically acceptable salts thereof: compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.
    Type: Grant
    Filed: April 2, 2013
    Date of Patent: February 10, 2015
    Assignee: Arizona Board of Regents, A Body Corporate of the State of Arizona Acting for and on Behalf of Arizona State University
    Inventors: Sidney Hecht, Omar Khdour, Jun Lu, Pablo Arce
  • NOVEL NICOTINE DNA VACCINES
    Publication number: 20150017201
    Abstract: The present invention provides DNA-nanostructures comprising and at least one targeting moiety, wherein the at least one targeting moiety is linked to the DNA-nanostructure; and wherein the at least one targeting moiety is nicotine or a nicotine analogue. These compounds elicit an immunogenic response in individuals and are useful as vaccines for ameliorating nicotine dependence.
    Type: Application
    Filed: March 13, 2014
    Publication date: January 15, 2015
    Inventors: Yung Chang, Hao Yan, Sidney Hecht, Paul Pentel, Xiaowei Liu, Rumit Maini
  • 1H-Pyrrolo [2, 3 -B] Pyridine Derivatives and Their Use as Radical Quenchers
    Publication number: 20150011580
    Abstract: The present disclosure provides biologically active compounds of formula (I): and pharmaceutically acceptable salts thereof, compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.
    Type: Application
    Filed: February 11, 2013
    Publication date: January 8, 2015
    Applicant: ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA, ACTING FOR AND ON BEHALF OF
    Inventors: Jose I. Armendariz Guajardo, Sidney Hecht, Omar Khdour, Xiaoqing Cai
  • Multifunctional Radical Quenchers For The Treatment Of Mitochondrial Dysfunction
    Publication number: 20140038963
    Abstract: The present disclosure provides methods for identifying therapeutic agents that are multifunctional radical quenchers. It also provides compounds of formula (I), (II), or (II-A): and pharmaceutically acceptable salts thereof, compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.
    Type: Application
    Filed: April 4, 2012
    Publication date: February 6, 2014
    Inventors: Sidney Hecht, Omar Khdour, Sandipan Roy Chowdhury, Poulami Talukder
  • Methods and Compositions for Using Bleomycin-Derivatized Microbubbles
    Publication number: 20130266518
    Abstract: Methods and compositions for using tumor targeting compounds bound to microbubbles to facilitate drug delivery and diagnostic imaging at tumor sites.
    Type: Application
    Filed: June 5, 2013
    Publication date: October 10, 2013
    Inventors: Sidney Hecht, Marek Belohlavek
  • Multifunctional Radical Quenchers and Their Uses
    Publication number: 20130267546
    Abstract: The present disclosure provides biologically active compounds of formula (I): and pharmaceutically acceptable salts thereof: compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.
    Type: Application
    Filed: April 2, 2013
    Publication date: October 10, 2013
    Applicant: Arizona Board of Regents, a body corporate of the State of Arizona acting for and on behalf of Ari
    Inventors: Sidney HECHT, Omar KHDOUR, Jun LU, Pablo ARCE
  • Phenazopyridine Compounds
    Publication number: 20130040917
    Abstract: The present invention is directed to substituted phenazopyridines represented by Formula I. The present invention also relates to the discovery that compounds of Formula I have increased bioavailability as compared to unconjugated phenazopyridine.
    Type: Application
    Filed: September 14, 2012
    Publication date: February 14, 2013
    Applicant: Pinnacle Pharmaceuticals, Inc.
    Inventors: Sidney HECHT, Nour Eddine Fahmi, Samir D. Roy, George Bonneville
  • Phenazopyridine compounds
    Patent number: 8288365
    Abstract: The present invention is directed to substituted phenazopyridines represented by Formula I. The present invention also relates to the discovery that compounds of Formula I have increased bioavailability as compared to unconjugated phenazopyridine.
    Type: Grant
    Filed: January 26, 2011
    Date of Patent: October 16, 2012
    Assignee: Pinnacle Pharmaceuticals, Inc.
    Inventors: Sidney Hecht, Nour Eddine Fahmi, Samir D. Roy, George Bonneville
  • Carbohydrate-Mediated Tumor Targeting
    Publication number: 20120148502
    Abstract: Tumors can be selectively targeted via compounds provided herein according to the formula, or a pharmaceutically acceptable salt thereof, wherein RA and RB are as defined herein. Tumors can be imaged or targeted for therapeutic treatment using compounds described herein where at least one RA or at least one RB group comprises a imaging agent, a therapeutic agent, or a member of a specific binding pair which can be associated with a secondary imaging agent, such as a microbubble for ultrasonic imaging.
    Type: Application
    Filed: May 5, 2010
    Publication date: June 14, 2012
    Applicant: Arizona Board of Regents, a body corporate of the State of Ariz. acting for and on behalf of Ariz.
    Inventors: Sidney Hecht, Ryan Schmaltz, Krystal Tsosie
  • Phenazopyridine Compounds
    Publication number: 20110319367
    Abstract: The present invention is directed to substituted phenazopyridines represented by Formula I. The present invention also relates to the discovery that compounds of Formula I have increased bioavailability as compared to unconjugated phenazopyridine.
    Type: Application
    Filed: January 26, 2011
    Publication date: December 29, 2011
    Applicant: Pinnacle Pharmaceuticals, Inc.
    Inventors: Sidney Hecht, Nour Eddine Fahmi, Samir D. Roy, George Bonneville
  • Methods and Compositions for Using Bleomycin-Derivatized Microbubbles
    Publication number: 20110293530
    Abstract: Methods and compositions for using tumor targeting compounds bound to microbubbles to facilitate drug delivery and diagnostic imaging at tumor sites.
    Type: Application
    Filed: November 23, 2009
    Publication date: December 1, 2011
    Applicant: ARIZONIA BOARD OF REGENTS
    Inventors: Sidney Hecht, Marek Belohlavek