Patents by Inventor Siegfried Goldmann

Siegfried Goldmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESSES FOR PREPARING DIHYDROPYRIMIDINE DERIVATIVES AND INTERMEDIATES THEREOF
    Publication number: 20160244438
    Abstract: The present invention relates to processes for preparing a dihydropyrimidine derivative having Formula (I) or a tautomer thereof having Formula (Ia), as well as a intermediate thereof. The processes of the invention have simple operation, high optical purity of product, high yield and convenient work-up, which is suitable for industrial production.
    Type: Application
    Filed: November 27, 2014
    Publication date: August 25, 2016
    Applicant: SUNSHINE LAKE PHARMA CO., LTD.
    Inventors: Qingyun REN, Xinchang LIU, Zhifu ZOU, Guanghua YAN, Mingchao BI, Siegfried GOLDMANN, Yingjun ZHANG
  • Crystalline forms of dihydropyrimidine derivatives
    Patent number: 9403814
    Abstract: The present invention relates to crystalline forms of dihydropyrimidine derivatives, and pharmaceutical compositions comprising the crystalline forms disclosed herein, which may be used for preventing, managing, treating or lessening the severity of a viral disease in a patient, especially hepatitis B infection or a disease caused by hepatitis B infection.
    Type: Grant
    Filed: September 27, 2013
    Date of Patent: August 2, 2016
    Assignee: SUNSHINE LAKE PHARMA CO., LTD.
    Inventors: Yingjun Zhang, Qingyun Ren, Xinchang Liu, Chaolei Wang, Tianming Wang, Siegfried Goldmann
  • DIHYDROPYRIMIDINE COMPOUNDS AND THEIR APPLICATION IN PHARMACEUTICALS
    Publication number: 20160206616
    Abstract: Provided herein are dihydropyrimidine compounds and their pharmaceutical applications, especially for use in treating and preventing HBV diseases. Specifically, provided herein are compounds having Formula (I) or (Ia), or an enantiomer, a diastereoisomer, a tautomer, a hydrate, a solvate, or a pharmaceutically acceptable salt thereof, wherein the variables of the formulas are as defined in the specification. Also provided herein is the use of the compounds having Formula (I) or (Ia), or an enantiomer, a diastereoisomer, a tautomer, a hydrate, a solvate, or a pharmaceutically acceptable salt thereof for treating and preventing HBV diseases.
    Type: Application
    Filed: November 18, 2014
    Publication date: July 21, 2016
    Applicant: SUNSHINE LAKE PHARMA CO., LTD.
    Inventors: Yingjun Zhang, Xinchang LIU, Zhifu ZOU, Jinsheng LIANG, Siegfried GOLDMANN, Qingyun REN
  • Dihydropyrimidine compounds and their application in pharmaceuticals
    Patent number: 9340538
    Abstract: Provided herein are dihydropyrimidine compounds and their pharmaceutical applications, especially for use in treating and preventing HBV diseases. Specifically, provided herein are compounds having Formula (I) or (Ia), or an enantiomer, a diastereoisomer, a tautomer, a hydrate, a solvate, or a pharmaceutically acceptable salt thereof, wherein the variables of the formulas are as defined in the specification. Also provided herein is the use of the compounds having Formula (I) or (Ia), or an enantiomer, a diastereoisomer, a tautomer, a hydrate, a solvate, or a pharmaceutically acceptable salt thereof for treating and preventing HBV diseases.
    Type: Grant
    Filed: August 23, 2013
    Date of Patent: May 17, 2016
    Assignee: SUNSHINE LAKE PHARMA CO., LTD.
    Inventors: Yingjun Zhang, Qingyun Ren, Xinchang Liu, Siegfried Goldmann
  • CRYSTALLINE FORMS OF DIHYDROPYRIMIDINE DERIVATIVES
    Publication number: 20150239877
    Abstract: The present invention relates to crystalline forms of dihydropyrimidine derivatives, and pharmaceutical compositions comprising the crystalline forms disclosed herein, which may be used for preventing, managing, treating or lessening the severity of a viral disease in a patient, especially hepatitis B infection or a disease caused by hepatitis B infection.
    Type: Application
    Filed: September 27, 2013
    Publication date: August 27, 2015
    Applicant: SUNSHINE LAKE PHARMA CO., LTD.
    Inventors: Yingjun Zhang, Qingyun Ren, Xinchang Liu, Chaolei Wang, Tianming Wang, Siegfried Goldmann
  • DIHYDROPYRIMIDINE COMPOUNDS AND THEIR APPLICATION IN PHARMACEUTICALS
    Publication number: 20150152096
    Abstract: Provided herein are dihydropyrimidine compounds and their pharmaceutical applications, especially for use in treating and preventing HBV diseases. Specifically, provided herein are compounds having Formula (I) or (Ia), or an enantiomer, a diastereoisomer, a tautomer, a hydrate, a solvate, or a pharmaceutically acceptable salt thereof, wherein the variables of the formulas are as defined in the specification. Also provided herein is the use of the compounds having Formula (I) or (Ia), or an enantiomer, a diastereoisomer, a tautomer, a hydrate, a solvate, or a pharmaceutically acceptable salt thereof for treating and preventing HBV diseases.
    Type: Application
    Filed: August 23, 2013
    Publication date: June 4, 2015
    Applicant: SUNSHINE LAKE PHARMA CO., LTD.
    Inventors: Yingjun ZHANG, Qingyun REN, Xinchang LIU, Siegfried GOLDMANN
  • Bromo-phenyl substituted thiazolyl dihydropyrimidines
    Patent number: 8236797
    Abstract: This invention relates to a bromo-phenyl substituted thiazolyl dihydropyrimidine, its preparation method and use as a medicament for treating and preventing hepatitis B infections. The invention also relates to a composition comprising the dihydropyrimidine, one or more antiviral agents and, optionally, an immunomodulator for treating and preventing HBV infections.
    Type: Grant
    Filed: June 18, 2008
    Date of Patent: August 7, 2012
    Assignee: Sunshine Lake Pharma Co., Ltd.
    Inventors: Siegfried Goldmann, Jing Li, Yi Song Liu
  • 3,5-Difluoropyridines
    Patent number: 7514565
    Abstract: The invention relates to compounds of the formule
    Type: Grant
    Filed: December 15, 2006
    Date of Patent: April 7, 2009
    Assignee: Bayer AG
    Inventors: Jürgen Stoltefuβ, Siegfried Goldmann, Thomas Krämer, Karl-Heinz Schlemmer, Ulrich Niewöhner, Maria Niewöhner, Arnold Paeβens, Erwin Graef, Stefan Lottmann, Karl Deres, Olaf Weber, Jörn Stölting
  • Dihydropyrimidines
    Publication number: 20070117812
    Abstract: The invention relates to compounds of the formulae
    Type: Application
    Filed: December 15, 2006
    Publication date: May 24, 2007
    Applicant: Bayer Aktiengesellschaft
    Inventors: Jurgen Stoltefuss, Siegfried Goldmann, Thomas Kramer, Karl-Heinz Schlemmer, Ulrich Niewohner, Maria Niewohner, Arnold Paessens, Erwin Graef, Stefan Lottmann, Karl Deres, Olaf Weber, Jorn Stolting
  • Medicaments against viral diseases
    Patent number: 7074784
    Abstract: Novel dihydropyrimidines and combinations thereof with other antiviral agents, suitable for combating HBV infections.
    Type: Grant
    Filed: March 5, 2001
    Date of Patent: July 11, 2006
    Inventors: Siegfried Goldmann, Jurgen Stoltefuss, Maria Niewohner, legal representative, Karl-Heinz Schlemmer, Jorg Keldenich, Arnold Paessens, Erwin Graef, Olaf Weber, Karl Deres, Ulrich Niewohner, deceased
  • Method for separating methyl 4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoro-2-pyridinyl)-6-methyl-1,4-dihydro-5-pyrimidine-carboxylate-recemate
    Patent number: 6987185
    Abstract: The enantiomers of methyl 4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoro-2-pyridinyl)-6-methyl)-1,4-dihydro-5-pyrimidinecarboxylate can be separated with the aid of (?)-camphanic acid.
    Type: Grant
    Filed: May 15, 2002
    Date of Patent: January 17, 2006
    Assignee: Bayer HealthCare AG
    Inventors: Siegfried Goldmann, Peter Fey
  • 3-'Hydroxy-(-4-trifluoromethylphenyl)-methyl-7-spirocyclobutyl-5,6,7 8-tetrahydroquinolin-5-ol derivatives and the use of the same as cholesterol ester transfer protein (cetp) inhibitors
    Publication number: 20050043341
    Abstract: The application relates to substituted tetrahydroquinoline derivatives, processes for their preparation and their use in medicaments.
    Type: Application
    Filed: September 18, 2002
    Publication date: February 24, 2005
    Inventors: Heike Gielen, Siegfried Goldmann, Jorg Keldenich, Holger Paulsen, Carsten Schmeck, Stephan Siegel, Hilmar Bischoff, Martin Raabe, Delf Schmidt, Christiane Faeste
  • Cycloalkano-indole and -azaindole derivatives
    Patent number: 6858622
    Abstract: Cycloalkano-indole and -azaindole derivatives are prepared by reaction of appropriately substituted carboxylic acids with amines. The cycloalkano-indole and -azaindole derivatives are suitable as active compounds for medicaments, preferably antiatherosclerotic medicaments.
    Type: Grant
    Filed: July 18, 2002
    Date of Patent: February 22, 2005
    Assignee: Bayer Aktiengesellschaft
    Inventors: Ulrich Müller, Richard Connell, Siegfried Goldmann, Rudi Grützmann, Martin Beuck, Hilmar Bischoff, Dirk Denzer, Anke Domdey-Bette, Stefan Wohlfeil
  • Method for separating methyl 4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoro-2-pyridinyl)-6-methyl-1,4-dihydro-5-pyrimidine-carboxylate-racemate
    Publication number: 20040242878
    Abstract: The enantiomers of methyl 4-(2-chloro-4-fluorphenyl)-2-(3,5-difluoro-2-pyridinyl)-6-methyl-1,4-dihydro-5-pyrimidinecarhoxylate can be separated with the aid of (−)-camphanic acid.
    Type: Application
    Filed: July 15, 2004
    Publication date: December 2, 2004
    Inventors: Siegfried Goldmann, Peter Fey
  • Dihydropyrimidines
    Publication number: 20040167135
    Abstract: The invention relates to compounds of the general formulae (I) and (Ia) 1
    Type: Application
    Filed: February 17, 2004
    Publication date: August 26, 2004
    Applicant: Bayer Aktiengesellschaft
    Inventors: Jurgen Stoltefuss, Siegfried Goldmann, Thomas Kramer, Karl-Heinz Schlemmer, Ulrich Niewohner, Arnold Paessens, Erwin Graef, Stefan Lottmann, Karl Deres, Olaf Weber, Jorn Stolting
  • Medicaments against viral diseases
    Publication number: 20030232842
    Abstract: Novel dihydropyrimidines and combinations thereof with other antiviral agents, suitable for combating HBV infections.
    Type: Application
    Filed: March 10, 2003
    Publication date: December 18, 2003
    Inventors: Siegfried Goldmann, Jurgen Stoltefuss, Ulrich Niewohner, Karl-Heinz Schlemmer, Jorg Keldenich, Arnold Paessens, Erwin Graef, Olaf Weber, Karl Deres
  • Cycloalkano-indole and -azaindole derivatives
    Publication number: 20030149073
    Abstract: Cycloalkano-indole and -azaindole derivatives are prepared by reaction of appropriately substituted carboxylic acids with amines. The cycloalkano-indole and -azaindole derivatives are suitable as active compounds for medicaments, preferably antiatherosclerotic medicaments.
    Type: Application
    Filed: July 18, 2002
    Publication date: August 7, 2003
    Inventors: Ulrich Muller, Richard Connell, Siegfried Goldmann, Rudi Grutzmann, Martin Beuck, Hilmar Bischoff, Dirk Denzer, Anke Domdey-Bette, Stefan Wohlfeil
  • 2-heterocyclically substituted dihydropyrimidines
    Patent number: 6503913
    Abstract: The invention relates to new 2-heterocyclically substituted dihydropyrimidines, medicaments which contain these 2-heterocyclically substituted dihydropyrimidines, and a process for preparation of medicaments. The invention furthermore relates to the use of the 2-heterocyclically substituted dihydropyrimidines for the production of a medicament, in particular for the treatment of acute or chronic viral diseases, in particular for the production of a medicament for the treatment of acute or chronic hepatitis B infections.
    Type: Grant
    Filed: October 18, 2000
    Date of Patent: January 7, 2003
    Assignee: Bayer Aktiengesellschaft
    Inventors: Siegfried Goldmann, Jürgen Stoltefuss, Arnold Paessens, Erwin Graef, Stefan Lottmann
  • Bromo-phenyl substituted thiazolyl dihydropyrimidines
    Patent number: RE44987
    Abstract: This invention relates to a bromo-phenyl substituted thiazolyl dihydropyrimidine, its preparation method and use as a medicament for treating and preventing hepatitis B infections. The invention also relates to a composition comprising the dihydropyrimidine, one or more antiviral agents and, optionally, an immunomodulator for treating and preventing HBV infections.
    Type: Grant
    Filed: April 25, 2013
    Date of Patent: July 1, 2014
    Assignee: Sunshine Lake Pharma Co., Ltd.
    Inventors: Siegfried Goldmann, Jing Li, Yi Song Liu
  • Bromo-phenyl substituted thiazolyl dihydropyrimidines
    Patent number: RE45004
    Abstract: This invention relates to a bromo-phenyl substituted thiazolyl dihydropyrimidine, its preparation method and use as a medicament for treating and preventing hepatitis B infections. The invention also relates to a composition comprising the dihydropyrimidine, one or more antiviral agents and, optionally, an immunomodulator for treating and preventing HBV infections.
    Type: Grant
    Filed: April 24, 2013
    Date of Patent: July 8, 2014
    Assignee: Sunshine Lake Pharma Co., Ltd.
    Inventors: Siegfried Goldmann, Jing Li, Yi Song Liu