Patents by Inventor Siegfried Looser

Siegfried Looser has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6376206
    Abstract: An immunoassay for the determination of myocardial necroses using antibodies to troponin T and a binding partner B for troponin T or for the an antibody, whereby either the antibody or the binding partner B is labelled with a determinable group. The immunological complex formed which contains the determinable group is isolated by separation of the phases and the determinable group is determined in one of the phases. Furthermore, monoclonal and polyclonal antibodies to troponin T are described with a cross-reactivity of less than 5% to skeletal muscle troponin T and less than 2% to troponin I and other myofibrillar proteins.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: April 23, 2002
    Assignee: Roche Diagnostics GmbH
    Inventors: Hugo Katus, Anneliese Borgya, Klaus Hallermayer, Siegfried Looser
  • Patent number: 6333397
    Abstract: An immunoassay for the determination of myocardial necroses using antibodies to troponin T and a binding partner B for troponin T or for the an antibody, whereby either the antibody or the binding partner B is labelled with a determinable group. The immunological complex formed which contains the determinable group is isolated by separation of the phases and the determinable group is determined in one of the phases. Furthermore, monoclonal and polyclonal antibodies to troponin T are described with a cross-reactivity of less than 5% to skeletal muscle troponin T and less than 2% to troponin I and other myofibrillar proteins.
    Type: Grant
    Filed: February 17, 2000
    Date of Patent: December 25, 2001
    Assignee: Roche Diagnostics GmbH
    Inventors: Hugo Katus, Anneliese Borgya, Klaus Hallermayer, Siegfried Looser
  • Patent number: 4378227
    Abstract: A process for dissolving chylomicrons in an aqueous medium composed of (a) at least one polyethylene glycol ether of an alkanol or alkylaryl alcohol with a branched alkane chain and with an HLB value of 12 to 14, and (b) at least one secondary alkyl sulphonate containing 10 to 20 carbon atoms in the molecule, and optionally (c) an alkali metal p-toluenesulphonate; andthe agent formed by the combination of (a), (b) and optionally (c).
    Type: Grant
    Filed: May 20, 1981
    Date of Patent: March 29, 1983
    Assignee: Boehringer Mannheim GmbH
    Inventors: Hans-Georg Batz, Siegfried Looser
  • Patent number: 4330620
    Abstract: A method for the determination of creatine kinase-MB in serum by immunological exclusion of sub-unit M and measurement of the sub-unit B for the determination of creatine kinase, the improvement comprising, for the purpose of excluding the sub-unit M, adding to the reaction mixture comprising determination reagents and the creatine kinase-containing sample, monovalent fragments obtained from antibodies against the sub-unit M by proteolytic cleavage under reducing conditions.
    Type: Grant
    Filed: February 28, 1980
    Date of Patent: May 18, 1982
    Assignee: Boehringer Mannheim GmbH
    Inventors: Wolfgang Gruber, Helmut Lenz, Siegfried Looser, Hans-Ralf Linke
  • Patent number: 4273870
    Abstract: Method and composition for the determination of glycerol using glycerin dehydrogenase, an electron transfer agent, NAD and a tetrazolium salt and, in addition, at least one microgram of zinc, in the form of a zinc salt, per 50 U of glycerol dehydrogenase.
    Type: Grant
    Filed: July 5, 1979
    Date of Patent: June 16, 1981
    Assignee: Boehringer Mannheim GmbH
    Inventors: Hans Mollering, Siegfried Looser
  • Patent number: 4162979
    Abstract: A device for the chemical and/or physical treatment of liquids which comprises a flowthrough vessel having an inlet and an outlet and is receptive of a treatment agent therebetween. The vessel comprises a substantially cylindrical tube having one end at the outlet and a conically widening tube section connected to the other end of the cylindrical tube. A permeable carrier is mounted in the cylindrical tube at the outlet end to support the treatment agent placed in the cylindrical tube.
    Type: Grant
    Filed: October 18, 1977
    Date of Patent: July 31, 1979
    Assignee: Boehringer Mannheim GmbH
    Inventors: August W. Wahlefeld, Siegfried Looser, Klaus A. Sturmann