Patents by Inventor Sifei Han

Sifei Han has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Lipid prodrugs of neurosteroids
    Patent number: 11975073
    Abstract: The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.
    Type: Grant
    Filed: June 26, 2023
    Date of Patent: May 7, 2024
    Assignees: PureTech LYT, Inc., Monash University
    Inventors: Daniel Kenneth Bonner, Rishab R. Shyam, Jamie Simpson, Christopher John Porter, Natalie Trevaskis, Tim Quach, Sifei Han, Luojuan Hu
  • Lipid prodrugs of mycophenolic acid and uses thereof
    Patent number: 11938137
    Abstract: The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, and methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.
    Type: Grant
    Filed: January 27, 2022
    Date of Patent: March 26, 2024
    Assignees: PureTech LYT, Inc., Monash University
    Inventors: Daniel Kenneth Bonner, Ketki Karanam, Sifei Han, Luojuan Hu, Christopher John Hamilton Porter, Tim Quach, Rishab R. Shyam, Jamie Simpson, Natalie Trevaskis
  • LYMPH DIRECTING PRODRUGS
    Publication number: 20240050573
    Abstract: The present invention relates to compounds and their uses, in particular, compounds in the form of prodrugs that promote transport of a pharmaceutical agent to the lymphatic system and subsequently enhance release of the parent drug.
    Type: Application
    Filed: June 28, 2023
    Publication date: February 15, 2024
    Applicant: Monash University
    Inventors: Christopher John Porter, Jamie Simpson, Natalie Trevaskis, Tim Quach, Sifei Han, Luojuan Hu
  • Lymphatic system-directing lipid prodrugs
    Patent number: 11883497
    Abstract: The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a provided lipid prodrug or a pharmaceutical composition thereof.
    Type: Grant
    Filed: August 29, 2018
    Date of Patent: January 30, 2024
    Assignees: PureTech LYT, Inc., Monash University
    Inventors: Daniel Kenneth Bonner, Ketki Karanam, James T. Mutamba, Rishab R. Shyam, Jamie Simpson, Sifei Han, Luojuan Hu, Christopher John Hamilton Porter, Tim Quach, Natalie Trevaskis
  • LIPID PRODRUGS OF NEUROSTEROIDS
    Publication number: 20230338552
    Abstract: The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.
    Type: Application
    Filed: June 26, 2023
    Publication date: October 26, 2023
    Applicants: PureTech LYT, Inc., Monash University
    Inventors: Daniel Kenneth Bonner, Rishab R. Shyam, Jamie Simpson, Christopher John Porter, Natalie Trevaskis, Tim Quach, Sifei Han, Luojuan Hu
  • Lymph directing prodrugs
    Patent number: 11738087
    Abstract: The present invention relates to compounds and their uses, in particular, compounds in the form of prodrugs that pro mote transport of a pharmaceutical agent to the lymphatic system and subsequently enhance release of the parent drug.
    Type: Grant
    Filed: September 8, 2016
    Date of Patent: August 29, 2023
    Assignee: Monash University
    Inventors: Chris Porter, Jamie Simpson, Natalie Trevaskis, Tim Quach, Sifei Han, Luojuan Hu
  • Lipid prodrugs of rapamycin and its analogs and uses thereof
    Patent number: 11608345
    Abstract: The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: March 21, 2023
    Assignees: PureTech LYT, Inc., Monash University
    Inventors: Daniel Kenneth Bonner, Sifei Han, Luojuan Hu, Ketki Karanam, Christopher John Porter, Tim Quach, Rishab R. Shyam, Jamie Simpson, Natalie Trevaskis
  • LIPID PRODRUGS OF RAPAMYCIN AND ITS ANALOGS AND USES THEREOF
    Publication number: 20230062834
    Abstract: The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.
    Type: Application
    Filed: December 19, 2018
    Publication date: March 2, 2023
    Inventors: Daniel Kenneth BONNER, Sifei HAN, Luojuan HU, Ketki KARANAM, Christopher John PORTER, Tim QUACH, Rishab R. SHYAM, Jamie SIMPSON, Natalie TREVASKIS
  • LIPID PRODRUGS OF NEUROSTEROIDS
    Publication number: 20220395513
    Abstract: The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.
    Type: Application
    Filed: August 4, 2022
    Publication date: December 15, 2022
    Applicants: PureTech LYT, Inc., Monash University
    Inventors: Daniel Kenneth Bonner, Rishab R. Shyam, Jamie Simpson, Christopher John Porter, Natalie Trevaskis, Tim Quach, Sifei Han, Luojuan Hu
  • METHODS AND COMPOUNDS FOR TREATMENT OF METABOLIC DISEASE
    Publication number: 20220339168
    Abstract: The present invention provides methods of treating metabolic diseases including obesity, insulin resistance and type 2 diabetes with inhibitors of COX-2 or VEGFR and lipid prodrugs of COX-2 inhibitors, in particular celecoxib lipid prodrugs, that promote transport of the pharmaceutical agent to the lymphatic system and which enhance release of the parent agent.
    Type: Application
    Filed: September 21, 2020
    Publication date: October 27, 2022
    Inventors: Natalie TREVASKIS, Christopher John PORTER, Tim QUACH, Sifei HAN, Enyuan CAO, Luojuan HU, Matthew WATT
  • LYMPH DIRECTING PRODRUGS
    Publication number: 20220211664
    Abstract: The present invention relates to compounds and their uses, in particular, compounds in the form of prodrugs that promote transport of a pharmaceutical agent to the lymphatic system and subsequently enhance release of the parent drug.
    Type: Application
    Filed: March 17, 2022
    Publication date: July 7, 2022
    Applicant: Monash University
    Inventors: Chris Porter, Jamie Simpson, Natalie Trevaskis, Tim Quach, Sifei Han, Luojuan Hu
  • LIPID PRODRUGS OF MYCOPHENOLIC ACID AND USES THEREOF
    Publication number: 20220143038
    Abstract: The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, and methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.
    Type: Application
    Filed: January 27, 2022
    Publication date: May 12, 2022
    Applicants: PureTech LYT, Inc., Monash University
    Inventors: Daniel Kenneth Bonner, Ketki Karanam, Sifei Han, Luojuan Hu, Christopher John Hamilton Porter, Tim Quach, Rishab R. Shyam, Jamie Simpson, Natalie Trevaskis
  • LIPID PRODRUGS OF JAK INHIBITORS AND USES THEREOF
    Publication number: 20220125933
    Abstract: The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, and methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.
    Type: Application
    Filed: February 28, 2020
    Publication date: April 28, 2022
    Inventors: Joseph BOLEN, Daniel Kenneth BONNER, Ketki KARANAM, Christopher John PORTER, Jamie SIMPSON, Natalie TREVASKIS, Dan ZHENG, Nathania LEONG, Garima SHARMA, Mitchell MCINERNEY, Tim QUACH, Sifei HAN
  • Lymph directing prodrugs
    Patent number: 11311512
    Abstract: The present invention relates to compounds and their uses, in particular, compounds in the form of prodrugs that promote transport of a pharmaceutical agent to the lymphatic system and subsequently enhance release of the parent drug.
    Type: Grant
    Filed: August 12, 2015
    Date of Patent: April 26, 2022
    Assignee: Monash University
    Inventors: Chris Porter, Jamie Simpson, Natalie Trevaskis, Tim Quach, Sifei Han, Luojuan Hu
  • Lipid prodrugs of mycophenolic acid and uses thereof
    Patent number: 11304954
    Abstract: The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, and methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: April 19, 2022
    Assignees: PureTech LYT, Inc., Monash University
    Inventors: Daniel Kenneth Bonner, Ketki Karanam, Sifei Han, Luojuan Hu, Christopher John Hamilton Porter, Tim Quach, Rishab R. Shyam, Jamie Simpson, Natalie Trevaskis
  • LYMPHATIC SYSTEM-DIRECTING LIPID PRODRUGS
    Publication number: 20220001015
    Abstract: The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a provided lipid prodrug or a pharmaceutical composition thereof.
    Type: Application
    Filed: August 29, 2018
    Publication date: January 6, 2022
    Inventors: Daniel Kenneth Bonner, Ketki Karanam, James T. Mutamba, Rishab R. Shyam, Jamie Simpson, Sifei Han, Luojuan Hu, Christopher John Hamilton Porter, Tim Quach, Natalie Trevaskis
  • LIPID PRODRUGS OF PREGNANE NEUROSTEROIDS AND USES THEREOF
    Publication number: 20210300962
    Abstract: The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.
    Type: Application
    Filed: August 2, 2019
    Publication date: September 30, 2021
    Inventors: Daniel Kenneth BONNER, Ketki KARANAM, Jamie SIMPSON, Christopher John PORTER, Natalie TREVASKIS, Tim QUACH, Sifei HAN, Luojuan HU
  • LIPID PRODRUGS OF NEUROSTEROIDS
    Publication number: 20210268115
    Abstract: The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.
    Type: Application
    Filed: February 5, 2021
    Publication date: September 2, 2021
    Inventors: Daniel Kenneth BONNER, Rishab R. SHYAM, Jamie SIMPSON, Christopher John PORTER, Natalie TREVASKIS, Tim QUACH, Sifei HAN, Luojuan HU
  • LIPID PRODRUGS OF MYCOPHENOLIC ACID AND USES THEREOF
    Publication number: 20200390777
    Abstract: The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, and methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.
    Type: Application
    Filed: December 19, 2018
    Publication date: December 17, 2020
    Inventors: Daniel Kenneth BONNER, Ketki KARANAM, Sifei HAN, Luojuan HU, Christopher John Hamilton PORTER, Tim QUACH, Rishab R. SHYAM, Jamie SIMPSON, Natalie TREVASKIS
  • LYMPH DIRECTING PRODRUGS
    Publication number: 20190105299
    Abstract: The present invention relates to compounds and their uses, in particular, compounds in the form of prodrugs that promote transport of a pharmaceutical agent to the lymphatic system and subsequently enhance release of the parent drug.
    Type: Application
    Filed: December 4, 2018
    Publication date: April 11, 2019
    Inventors: Christopher John Hamilton Porter, Jamie Simpson, Natalie Trevaskis, Tim Quach, Sifei Han, Luojuan Hu