Patents by Inventor Sigeru Torii
Sigeru Torii has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4499265Abstract: This invention provides a process for preparing a 3-exo-methylenecepham derivative represented by the formula ##STR1## wherein R.sup.1 represents an aralkyl or aryloxymethyl group both of which may be substituted on the aromatic ring, and R.sup.2 represents a carboxyl-protecting group, the process comprising subjecting a compound represented by the formula ##STR2## wherein R.sup.1 and R.sup.2 are as defined above, to a cyclization reaction in an acidic water-containing solvent.Type: GrantFiled: August 9, 1982Date of Patent: February 12, 1985Assignee: Otsuka Kagaku Yakuhin Kabushiki KaishaInventors: Sigeru Torii, Hideo Tanaka, Junzo Nokami, Takashi Shiroi, Norio Saito, Michio Sasaoka
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Patent number: 4482435Abstract: This invention provides a process for preparing a thiazolidine compound of the formula ##STR1## wherein R.sup.1 represents a hydrogen atom, alkyl group, aralkyl group, aryl group or aryloxymethyl group, and R.sup.2 represents a hydrogen atom or a group ##STR2## wherein R.sup.3 represents a hydrogen atom, alkyl group, halogenated alkyl group, benzyl group or silyl group, and X represents a hydrogen atom, halogen atom, hydroxy group, alkoxy group or acyloxy group, the process comprising electrolyzing a thiazoline compound represented by the formula ##STR3## wherein R.sup.1 and R.sup.2 are as defined above, in a mixture comprising a perchloric acid aqueous solution and an organic solvent.Type: GrantFiled: August 9, 1982Date of Patent: November 13, 1984Assignee: Otsuka Kagaku Yakuhin Kabushiki KaishaInventors: Sigeru Torii, Hideo Tanaka, Takashi Shiroi
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Patent number: 4482491Abstract: This invention provides thiazolinoazetidinone derivatives represented by the formula ##STR1## and processes for preparing the same. The thiazolinoazetidinone derivatives are used as the intermediates for producing cephalosporin compounds useful as antibiotic agents.Type: GrantFiled: April 20, 1982Date of Patent: November 13, 1984Assignee: Otsuka Kagaku Yakuhin Kabushiki KaishaInventors: Sigeru Torii, Hideo Tanaka, Junzo Nokami, Michio Sasaoka, Norio Saito, Takashi Shiroi, Akira Tanaka
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Patent number: 4470887Abstract: This invention provides a process for preparing a thiazolinoazetidinone derivative represented by the formula ##STR1## wherein R.sup.1 represents a hydrogen atom, alkyl group, alkenyl group, aralkyl group, aryl group or aryloxymethyl group, the process comprising electrolyzing in a solvent a compound represented by the formula ##STR2## wherein R.sup.1 is as defined above, R.sup.2 represents a carboxyl group or protected carboxyl group, and R.sup.3 and R.sup.4 represent a hydrogen atom, halogen atom or acetoxy group.Type: GrantFiled: August 9, 1982Date of Patent: September 11, 1984Assignee: Otsuka Kagaku Yakuhin Kabushiki KaishaInventors: Sigeru Torii, Hideo Tanaka, Norio Saito
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Patent number: 4464237Abstract: This invention provides a process for preparing a .beta.-lactam derivative represented by the formula ##STR1## wherein R.sup.1 represents aralkyl group or aryloxy methyl group, Y represents the group ##STR2## (wherein R.sup.2 represents aryl-substituted lower alkyl group, aryloxy-substituted lower alkyl group or lower alkyl group optionally substituted with halogen atom and X represents halogen atom) or the group ##STR3## (wherein R.sup.2 and X are as defined above), the process comprising electrolyzing an azetidinone derivative of the formula ##STR4## wherein R.sup.1 and R.sup.2 are as defined above in the presence of hydrohalogenic acid and/or halide.Type: GrantFiled: August 9, 1982Date of Patent: August 7, 1984Assignee: Otsuka Kagaku Yakuhin Kabushiki KaishaInventors: Sigeru Torii, Hideo Tanaka, Junzo Nokami, Takashi Shiroi, Michio Sasaoka, Norio Saito
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Patent number: 4401528Abstract: This invention provides a process for preparing 2-oxycephalosporin derivative represented by the formula ##STR1## wherein R.sup.1 represents hydrogen atom, acyl group, or lower alkoxycarbonyl group optionally substituted with halogen atom, R.sup.2 represents hydrogen atom, halogen atom or acyloxy group optionally substituted with halogen atom, R.sup.3 represents hydrogen atom, lower alkyl group optionally substituted with halogen atom, or phenyl-lower alkyl group which may be optionally substituted with nitro group, halogen atom or lower alkoxy group on the phenyl ring, and R.sup.4 represents lower primary or secondary alkyl or lower alkylcarbonyl, the process comprising electrolytically oxidizing a cephalosporin derivative represented by the formula ##STR2## wherein R.sup.1, R.sup.2 and R.sup.3 are as defined above, in the presence of a lower carboxylic acid or lower primary or secondary alcohol, and a supporting electrolyte.Type: GrantFiled: August 12, 1982Date of Patent: August 30, 1983Assignee: Otsuka Kagaku Yakuhin Kabushiki KaishaInventors: Sigeru Torii, Hideo Tanaka, Junzo Nokami, Takashi Shiroi, Norio Saito, Michio Sasaoka
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Patent number: 4392923Abstract: This invention provides a process for preparing a thiazolinoazetidinone derivative represented by the formula ##STR1## wherein R.sup.1 represents aralkyl group or aryloxymethyl group and R.sup.2 represents acyl group, the process comprising electrolyzing a compound of the formula ##STR2## wherein R.sup.1 is as defined above in the presence of a lower fatty acid.Type: GrantFiled: August 9, 1982Date of Patent: July 12, 1983Assignee: Otsuka Kagaku Yakuhin Kabushiki KaishaInventors: Sigeru Torii, Hideo Tanaka, Junzo Nokami, Michio Sasaoka, Norio Saito, Takashi Shiroi
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Patent number: 4379032Abstract: This invention provides a process for preparing an oxazolineazetidinone derivative represented by the formula ##STR1## (wherein R.sup.1 represents hydrogen atom, alkyl group, alkenyl group, substituted or unsubstituted aralkyl group, substituted or unsubstituted aryl group, or substituted or unsubstituted aryloxymethyl group, R.sup.2 represents free or protected carboxyl group and R.sup.3 represents hydrogen atom or methoxy group) from a penicillin derivative represented by the formula ##STR2## wherein R.sup.1, R.sup.2 and R.sub.3 are as defined above.Type: GrantFiled: August 9, 1982Date of Patent: April 5, 1983Assignee: Otsuka Kagaku Yakuhin Kabushiki KaishaInventors: Sigeru Torii, Hideo Tanaka, Junzo Nokami, Takashi Shiroi, Norio Saito, Michio Sasaoka
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Patent number: 4336202Abstract: Novel cyclohexanone derivatives of general formula: ##STR1## (wherein R.sup.1 is a hydrocarbon group of 1 to 15 carbon atoms) and new cyclohexanone derivatives of general formula: ##STR2## (wherein R.sup.1 and R.sup.2 each is a hydrocarbon group of 1 to 15 carbon atoms) are produced by an electrooxidative coupling of 1,3-cyclohexanedione with a vinyl ether of general formula:CH.sub.2 .dbd.CH-O-R.sup.1(wherein R.sup.1 is as defined above) in the presence or absence of an alcohol of general formula:R.sup.2 OH(wherein R.sup.2 is as defined above). These new cyclohexanone derivatives can be easily converted to N-substituted or unsubstituted-4-oxo-4,5,6,7-tetrahydroindoles, which are of value as intermediates for the production of N-substituted or unsubstituted-4-hydroxyindoles and, thence, to pindolol and its analogs.Type: GrantFiled: May 18, 1981Date of Patent: June 22, 1982Assignee: Kuraray Co., Ltd.Inventors: Sigeru Torii, Kenji Uneyama, Takashi Onishi, Yoshiji Fujita, Michihiro Ishiguro, Takashi Nishida
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Patent number: 4238615Abstract: 2-Substituted-cyclopentanone derivatives represented by the formula ##STR1## are prepared by subjecting a 2-benzothiazolylsulfenamide derivative represented by the formula ##STR2## and cyclopentanone to condensation reaction, or by reacting the resulting condensation product with a hydrocarbon halide represented by the formulaR.sub.1 X.Type: GrantFiled: March 7, 1978Date of Patent: December 9, 1980Assignee: Otsuka Kagaku Yakuhin Kabushiki KaishaInventors: Sigeru Torii, Hideo Tanaka, Toshihiro Kudai
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Patent number: 4237308Abstract: A process for preparing 2-cyclopentenone derivative represented by the formula ##STR1## wherein A is ##STR2## and R.sub.2 is lower straight-chain or branched-chain alkyl, alkenyl or aralkyl, and perfume composition containing the derivative.Type: GrantFiled: June 8, 1978Date of Patent: December 2, 1980Assignee: Otsuka Kagaku Yakuhin Kabushiki KaishaInventors: Sigeru Torii, Hideo Tanaka, Yuichi Kobayashi
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Patent number: 4219393Abstract: Sulfenimides are prepared by electrolytic oxidation of organic disulfides or mercaptans and imides. The electrolytic oxidation is accelerated by a halide compound.Type: GrantFiled: March 22, 1979Date of Patent: August 26, 1980Assignee: Ouchi Shinko Kagaku Kogyo Kabushiki KaishaInventors: Sigeru Torii, Hideo Tanaka, Masashi Ukida
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Patent number: 4186141Abstract: A process for preparing 2-pentynyl ether represented by the formulaCH.sub.3 CH.sub.2 C.tbd.CCH.sub.2 ORwherein R is tetrahydropyranyl and methoxyethyl characterized by reacting propargyl ether represented by the formula HC.tbd.CCH.sub.2 OR wherein R is as defined above with an ethyl halide in a nonprotonic polar solvent in the presence of a metal hydride.Type: GrantFiled: August 9, 1978Date of Patent: January 29, 1980Assignee: Otsuka Kagaku Yakuhin Kabushiki KaishaInventors: Sigeru Torii, Yuichi Kobayashi, Hideo Tanaka
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Patent number: 4173707Abstract: A cyclopentanol derivative represented by the formula ##STR1## wherein R.sub.1 and R.sub.2 are lower straight-chain or branched-chain alkyl, alkenyl or aralkyl, and R.sub.4 is 2-pentenyl or 2-pentynyl, and process for preparing the same.Type: GrantFiled: June 8, 1978Date of Patent: November 6, 1979Assignee: Otsuka Kagaku Yakuhin Kabushiki KaishaInventors: Sigeru Torii, Hideo Tanaka, Yuichi Kobayashi
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Patent number: 4166188Abstract: A 2-(2-pentynyl) cyclopentanol derivative represented by the formula ##STR1## wherein R.sub.2 is lower straight-chain or branched-chain alkyl, alkenyl or aralkyl, and process for preparing the same.Type: GrantFiled: June 8, 1978Date of Patent: August 28, 1979Assignee: Otsuka Kagaku Yakuhin Kabushiki KaishaInventors: Sigeru Torii, Hideo Tanaka, Yuichi Kobayashi
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Patent number: 4163111Abstract: A 2-cyclopentenone derivative represented by the formula ##STR1## wherein R.sub.1 and R.sub.2 are lower straight-chain or branched-chain alkyl, alkenyl or aralkyl, and R.sub.4 is 2-pentenyl or 2-pentynyl, and process for preparing the same.Type: GrantFiled: June 8, 1978Date of Patent: July 31, 1979Assignee: Otsuka Kagaku Yakuhim Kabushiki KaishaInventors: Sigeru Torii, Hideo Tanaka, Yuichi Kobayashi
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Patent number: 4148697Abstract: A tetraalkylthiuram disulfide is prepared in a higher yield without formation of by-products by subjecting the corresponding alkali metal dialkyldithiocarbamate to electrolytic oxidation, which is carried out in a two-layer electrolytic solution consisting essentially of either (1) water and carbon disulfide or (2) water and a mixture of carbon disulfide and a halogenated alkane of higher density than water, the carbon disulfide being predominant in the mixture, by means of electrodes placed in the aqueous layer containing the dialkyldithiocarbamate. The resulting disulfide is extracted to the lower layer of the electrolytic solution and is recovered from the layer. The dialkyldithiodicarbamate can be continuously produced in situ by adding carbon disulfide and dialkylamine gradually to the aqueous layer of the electrolytic solution, which contains an alkalimetal hydroxide produced during the electrolytic oxidation of the dialkyldithiocarbamate.Type: GrantFiled: February 1, 1978Date of Patent: April 10, 1979Assignee: Ouchi Shinko Kagaku Kogyo Kabushiki KaishaInventors: Sigeru Torii, Hideo Tanaka, Kiyoshi Mishima
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Patent number: 4127454Abstract: Benzothiazolylsulfenamides are prepared in a high yield and substantially without a side reaction, via direct electrolytic oxidation, by cross-coupling (1) 2-mercaptobenzothiazole or dibenzothiazyl disulfide or an alkali metal salt of 2-mercaptobenzothiazole with (2) a primary or secondary amine, in the presence of a solvent selected from a dipolar aprotic solvent, a protic solvent, water and mixtures thereof, as well as a supporting electrolyte having adaptability to the solvent.Type: GrantFiled: August 22, 1977Date of Patent: November 28, 1978Assignee: Ouchi Shinko Kagaku Kogyo Kabushiki KaishaInventors: Sigeru Torii, Hideo Tanaka, Masashi Ukida
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Patent number: 4120764Abstract: A process for producing a tetraalkylthiuram disulfide which comprises electrolytically oxidizing a dialkylammonium dialkyldithiocarbamate having the formula ##STR1## wherein each R represents an alkyl group having from 1 to 4 carbon atoms, in the presence or absence of a supporting electrolyte to produce a tetraalkylthiuram disulfide, the electrolytic oxidation being carried out in one or more solvents which dissolve at least one of the starting dialkylammonium dialkyldithiocarbamate and the resulting tetraalkylthiuram disulfide.Type: GrantFiled: January 16, 1978Date of Patent: October 17, 1978Assignee: Ouchi Shinko Kagaku Kogyo Kabushiki KaishaInventors: Sigeru Torii, Hideo Tanaka, Kiyoshi Mishima