Patents by Inventor Sigrid Wattler

Sigrid Wattler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6924146
    Abstract: The present invention provides a novel vector system and thereby a novel method for the simplified construction of recombinant vectors for directed mutagenesis. Said vector system is used to modify the eukaryotic genome, particularly of embryonic stem cells, at precise and predefined loci by the means of homologous recombination. Furthermore, said system finds its usage in the generation of new strategies for gene therapy and in the generation of genetically modified higher eukaryotic organisms.
    Type: Grant
    Filed: February 20, 1998
    Date of Patent: August 2, 2005
    Inventors: Sigrid Wattler, Michael Nehls
  • Publication number: 20040043487
    Abstract: The present invention provides a novel vector system and thereby a novel method for the simplified construction of recombinant vectors for directed mutagenesis. Said vector system is used to modify the eukaryotic genome, particularly of embryonic stem cells, at precise and predefined loci by the means of homologous recombination. Further more, said system finds its usage in the generation of new strategies for gene therapy and in the generation of genetically modified higher eukaryotic organisms.
    Type: Application
    Filed: August 6, 2003
    Publication date: March 4, 2004
    Inventors: Michael Nehls, Sigrid Wattler
  • Patent number: 6218123
    Abstract: A new technology is described that allows for the rapid and efficient construction of complex cDNA libraries from cultured eukaryotic cells. The technology exploits eukaryotic biology by using transgenic constructs that have been nonspecifically inserted into the genome to facilitate the expression of nuclear genes as fusion transcripts. The invention further allows one to specifically subclone the corresponding fusion transcripts into highly complex cDNA libraries. The libraries are easily characterized by molecular analysis techniques such as hybridization, and individual clones can be directly sequenced to generate a sequence database of the cellular portion of the fusion transcripts.
    Type: Grant
    Filed: August 10, 1999
    Date of Patent: April 17, 2001
    Assignee: Lexicon Genetics Incorporated
    Inventors: Michael Nehls, Brian Zambrowicz, Glenn Friedrich, H. Earl Ruley, Arthur T. Sands, Sigrid Wattler