Patents by Inventor Sigrun Metz

Sigrun Metz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Protease inhibitor conjugates and antibodies useful in immunoassay
    Patent number: 7569678
    Abstract: Activated haptens useful for generating immunogens to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in immunoassays for the HIV protease inhibitor saquinavir. The novel haptens feature an activated functionality at the central, non-terminal hydroxyl group. Also described are monoclonal antibodies specific for saquinavir having less than 10% cross-reactivity with lopinavir, nelfinavir, amprenavir, ritonavir, and indinavir, and a murine hybridoma producing said antibodies.
    Type: Grant
    Filed: January 31, 2007
    Date of Patent: August 4, 2009
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Gerald F. Sigler, Raymond A. Hui, Ina Deras, Erasmus Huber, Herbert W. Von Der Eltz, Sigrun Metz, Peter Kern
  • Protease inhibitor conjugates and antibodies useful in immunoassay
    Patent number: 7482437
    Abstract: Activated haptens useful for generating immunogens to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in immunoassays for the HIV protease inhibitor saquinavir. The novel haptens feature an activated functionality at the central, non-terminal hydroxyl group. Also described are monoclonal antibodies specific for saquinavir having less than 10% cross-reactivity with lopinavir, nelfinavir, amprenavir, ritonavir, and indinavir, and a murine hybridoma producing said antibodies.
    Type: Grant
    Filed: February 2, 2007
    Date of Patent: January 27, 2009
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Gerald F. Sigler, Raymond A. Hui, Ina Deras, Richard Terry Root, Mitali Ghoshal, Erasmus Huber, Herbert W. Von Der Eltz, Sigrun Metz, Peter Kern
  • Protease inhibitor conjugates and antibodies useful in immunoassay
    Publication number: 20080021201
    Abstract: Activated haptens useful for generating immunogen to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in immunoassays for the HIV protease inhibitor saquinavir. The novel haptens feature an activated functionality at the central, non-terminal hydroxyl group. Also described are monoclonal antibodies specific for saquinavir having less than 10% cross-reactivity with lopinavir, nelfinavir, amprenavir, ritonavir, and indinavir, and a murine hybridoma producing said antibodies.
    Type: Application
    Filed: February 1, 2007
    Publication date: January 24, 2008
    Inventors: Gerald Sigler, Raymond Hui, Ina Deras, Erasmus Huber, Herbert Von Der Eltz, Sigrun Metz, Peter Kern
  • Protease inhibitor conjugates and antibodies useful in immunoassay
    Publication number: 20070155959
    Abstract: Activated haptens useful for generating immunogens to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in immunoassays for the HIV protease inhibitor saquinavir. The novel haptens feature an activated functionality at the central, non-terminal hydroxyl group. Also described are monoclonal antibodies specific for saquinavir having less than 10% cross-reactivity with lopinavir, nelfinavir, amprenavir, ritonavir, and indinavir, and a murine hybridoma producing said antibodies.
    Type: Application
    Filed: January 31, 2007
    Publication date: July 5, 2007
    Inventors: Gerald Sigler, Raymond Hui, Ina Deras, Richard Root, Mitali Ghoshal, Erasmus Huber, Herbert Von Der Eltz, Sigrun Metz, Peter Kern
  • Protease inhibitor conjugates and antibodies useful in immunoassay
    Publication number: 20070148708
    Abstract: Activated haptens useful for generating immunogens to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in immunoassays for the HIV protease inhibitor saquinavor. The novel haptens feature an activated functionality at the central, non-terminal hydroxyl group. Also described are monoclonal antibodies specific for saquinavir having less than 10% cross-reactivity with lopinavir, nelfinavir, amprenavir, ritonavir, and indinavir, and a murine hybridoma producing said antibodies.
    Type: Application
    Filed: January 31, 2007
    Publication date: June 28, 2007
    Inventors: Gerald Sigler, Raymond Hui, Ina Deras, Richard Root, Mitali Ghoshal, Erasmus Huber, Herbert Von Der Eltz, Sigrun Metz, Peter Kern
  • Nelfinavir conjugates and antibodies useful in immunoassay
    Publication number: 20070149565
    Abstract: Activated haptens useful for generating immunogens to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in immunoassays for the HIV protease inhibitor saquinavir. The novel haptens feature an activated functionality at the central, non-terminal hydroxyl group. Also described are monoclonal antibodies specific for saquinavir having less than 10% cross-reactivity with lopinavir, nelfinavir, amprenavir, ritonavir, and indinavir, and a murine hybridoma producing said antibodies.
    Type: Application
    Filed: January 26, 2007
    Publication date: June 28, 2007
    Inventors: Gerald Sigler, Raymond Hui, Ina Deras, Richard Root, Mitali Ghoshal, Erasmus Huber, Herbert Von Der Eltz, Sigrun Metz, Peter Kern
  • Protease inhibitor conjugates and antibodies useful in immunoassay
    Publication number: 20070141643
    Abstract: Activated haptens useful for generating immunogens to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in immunoassays for the HIV protease inhibitor saquinavir. The novel haptens feature an activated functionality at the central, non-terminal hydroxyl group. Also described are monoclonal antibodies specific for saquinavir having less than 10% cross-reactivity with lopinavir, nelfinavir, amprenavir, ritonavir, and indinavir, and a murine hybridoma producing said antibodies.
    Type: Application
    Filed: February 2, 2007
    Publication date: June 21, 2007
    Inventors: Gerald Sigler, Raymond Hui, Ina Deras, Richard Root, Mitali Ghoshal, Erasmus Huber, Herbert Von Der Eltz, Sigrun Metz, Peter Kern
  • Protease inhibitor conjugates and antibodies useful in immunoassay
    Patent number: 7193065
    Abstract: Activated haptens useful for generating immunogens to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in immunoassays for HIV protease inhibitors. The novel haptens feature an activated functionality at the central, non-terminal hydroxyl group common to all HIV protease inhibitors, e.g., saquinavir, nelfinavir, indinavir, amprenavir, ritonavir, lopinavir, and atazanavir.
    Type: Grant
    Filed: September 24, 2003
    Date of Patent: March 20, 2007
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Gerald F. Sigler, Raymond A. Hui, Ina Deras, Richard Terry Root, Mitali Ghoshal, Erasmus Huber, Herbert W. Von Der Eltz, Sigrun Metz, Peter Kern
  • PROTEASE INHIBITOR CONJUGATES AND ANTIBODIES USEFUL IN IMMUNOASSAY
    Publication number: 20060264618
    Abstract: Monoclonal antibodies specific for lopinavir having less than 10% cross-reactivity with saquinavir, nelfinavir, amprenavir, ritonavir, and indinavir, and a murine hybridoma producing said antibodies are described.
    Type: Application
    Filed: May 26, 2006
    Publication date: November 23, 2006
    Inventors: Ina Deras, Gerald Sigler, Raymond Hui, Richard Root, Mitali Ghoshal, Erasmus Huber, Herbert Von Der Eltz, Sigrun Metz, Peter Kern
  • Protease inhibitor conjugates and antibodies useful in immunoassay
    Publication number: 20040127689
    Abstract: Activated haptens useful for generating immunogens to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in immunoassays for HIV protease inhibitors. The novel haptens feature an activated functionality at the central, non-terminal hydroxyl group common to all HIV protease inhibitors, e.g., saquinavir, nelfinavir, indinavir, amprenavir, ritonavir, lopinavir, and atazanavir.
    Type: Application
    Filed: September 24, 2003
    Publication date: July 1, 2004
    Inventors: Gerald F. Sigler, Raymond A. Hui, Ina Deras, Richard Terry Root, Mitali Ghoshal, Erasmus Huber, Herbert W. Von Der Eltz, Sigrun Metz, Peter Kern
  • Protease inhibitor conjugates and antibodies useful in immunoassay
    Publication number: 20030100088
    Abstract: Activated haptens useful for generating immunogens to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in immunoassays for HIV protease inhibitors. The novel haptens feature an activated functionality at the central, non-terminal hydroxyl group common to all HIV protease inhibitors, e.g., saquinavir, nelfinavir, indinavir, amprenavir, ritonavir and lopinavir.
    Type: Application
    Filed: July 10, 2002
    Publication date: May 29, 2003
    Inventors: Gerald F. Sigler, Raymond A. Hui, Ina Deras, Richard Terry Root, Mitali Ghoshal, Erasmus J. Huber, Herbert W. Von Der Eltz, Sigrun Metz