Patents by Inventor Sigrun R. H{umlaut over (u)}gl

Sigrun R. H{umlaut over (u)}gl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions relating to no-mediated cytotoxicity
    Patent number: 6171856
    Abstract: The present invention relates to methods and compositions for the treatment of diabetes involving free radicals. In particular, the present invention is directed to the treatment or prophylactic intervention of diabetes. The present invention demonstrates that MnSOD can play a protective role against cytokine killing, and provides strategies for engineering cell lines as islet surrogates for transplantation therapy of diabetes mellitus. Further, the present invention shows that &bgr;-cell destruction and dysfunction in adipogenic diabetes is mediated via fatty acids. Methods and compositions for ameliorating this disorder are provided herein.
    Type: Grant
    Filed: July 30, 1998
    Date of Patent: January 9, 2001
    Assignees: Board of Regents, The University of Texas System, Betagene, Inc
    Inventors: Anice Thigpen, Hans-Ewald Hohmeier, Christopher B. Newgard, Roger H. Unger, Michio Shimabukuro, Guoxun Chen, Christopher J. Rhodes, Sigrun R. H{umlaut over (u)}gl, Sharon Cousin