Patents by Inventor Silke Mittelstrass

Silke Mittelstrass has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Preparation of scFv antibody fragments
    Patent number: 9279017
    Abstract: The invention relates to methods of preparing antibody fragments. The invention further relates to antibody fragments prepared by these methods. The invention further relates to antibody variable regions comprised in antibody fragments producible by these methods.
    Type: Grant
    Filed: August 17, 2012
    Date of Patent: March 8, 2016
    Assignee: AMGEN RESEARCH (MUNICH) GMBH
    Inventors: Tobias Raum, Julia Henckel, Eva Krinner, Silke Mittelstrass, Andreas Wolf
  • Expression-enhanced polypeptides
    Patent number: 8518403
    Abstract: A composite polypeptide, said composite polypeptide comprising a desired polypeptide and an expression enhancing domain (“EED”), said EED comprising first and second cysteine amino acid residues Cys1 and Cys2, respectively, Cys1 being located closer to the N-terminus of the composite polypeptide molecule than Cys2, wherein Cys1 and Cys2 are separated by a polypeptide linker, said linker—being free of cysteine and proline;—defining a length sufficient to allow Cys1 and Cys2 to engage in an intramolecular disulfide bond with one another; and—having a flexible polypeptide conformation essentially free of secondary polypeptide structure in aqueous solution, wherein at least one of Cys1 and Cys2 is derivatized with a derivatization moiety.
    Type: Grant
    Filed: July 15, 2005
    Date of Patent: August 27, 2013
    Assignee: Amgen Research (Munich) GmbH
    Inventors: Patrick Hoffmann, Silke Mittelstrass, Jens Hennecke, Tobias Raum
  • PREPARATION OF SCFV ANTIBODY FRAGMENTS
    Publication number: 20130171165
    Abstract: The invention relates to methods of preparing antibody fragments. The invention further relates to antibody fragments prepared by these methods. The invention further relates to antibody variable regions comprised in antibody fragments producible by these methods.
    Type: Application
    Filed: August 17, 2012
    Publication date: July 4, 2013
    Applicant: AMGEN RESEARCH (MUNICH) GMBH
    Inventors: Tobias RAUM, Julia HENCKEL, Eva KRINNER, Silke MITTELSTRASS, Andreas WOLF
  • Preparation of scFv antibody fragments
    Patent number: 8247194
    Abstract: The invention relates to methods of preparing antibody fragments. The invention further relates to antibody fragments prepared by said methods. The invention further relates to antibody variable regions comprised in antibody fragments producible by said methods.
    Type: Grant
    Filed: May 4, 2005
    Date of Patent: August 21, 2012
    Assignee: Micromet AG
    Inventors: Tobias Raum, Julia Henckel, Eva Krinner, Silke Mittelstrass, Andreas Wolf
  • EXPRESSION-ENHANCED POLYPEPTIDES
    Publication number: 20090053223
    Abstract: A composite polypeptide, said composite polypeptide comprising a desired polypeptide and an expression enhancing domain (“EED”), said EED comprising first and second cysteine amino acid residues Cys1 and Cys2, respectively, Cys1 being located closer to the N-terminus of the composite polypeptide molecule than Cys2, wherein Cys1 and Cys2 are separated by a polypeptide linker, said linker—being free of cysteine and proline;—defining a length sufficient to allow Cys1 and Cys2 to engage in an intramolecular disulfide bond with one another; and—having a flexible polypeptide conformation essentially free of secondary polypeptide structure in aqueous solution, wherein at least one of Cys1 and Cys2 is derivatized with a derivatization moiety.
    Type: Application
    Filed: July 15, 2005
    Publication date: February 26, 2009
    Inventors: Patrick Hoffmann, Silke Mittelstrass, Jens Hennecke, Tobias Saum
  • Preparation of Scfv Antibody Fragments
    Publication number: 20080193978
    Abstract: The invention relates to methods of preparing antibody fragments. The invention further relates to antibody fragments prepared by said methods. The invention further relates to antibody variable regions comprised in antibody fragments producible by said methods.
    Type: Application
    Filed: May 4, 2005
    Publication date: August 14, 2008
    Inventors: Tobias Raum, Julia Henckel, Eva Krinner, Silke Mittelstrass, Andreas Wolf