Patents by Inventor Silvana Cappelletti

Silvana Cappelletti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Analysis of the molecular weight distribution of complex polypeptide mixtures
    Patent number: 10234461
    Abstract: The present invention relates to simple size exclusion chromatography (SEC) analytical methods useful for the assessment of accurate molecular weight distributions (MWDs) of certain polypeptide mixtures known as glatiramoids. The use of a SEC method based on one or more broad MWD standards furnishes the absolute (not relative) molecular weight distribution profile of complex polypeptide mixtures like, for instance, the glatiramer acetate (GA) polymer.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: March 19, 2019
    Assignee: CHEMI S.P.A.
    Inventors: Andrea Stevenazzi, Andrea Distaso, Aureliano Gaiassi, Eleonora Spuria, Silvana Cappelletti
  • Analysis of the Molecular Weight Distribution of Complex Polypeptide Mixtures
    Publication number: 20170089916
    Abstract: The present invention relates to simple size exclusion chromatography (SEC) analytical methods useful for the assessment of accurate molecular weight distributions (MWDs) of certain polypeptide mixtures known as glatiramoids. The use of a SEC method based on one or more broad MWD standards furnishes the absolute (not relative) molecular weight distribution profile of complex polypeptide mixtures like, for instance, the glatiramer acetate (GA) polymer.
    Type: Application
    Filed: September 23, 2016
    Publication date: March 30, 2017
    Inventors: Andrea Stevenazzi, Andrea Distaso, Aureliano Gaiassi, Eleonora Spuria, Silvana Cappelletti
  • Process for the formation of disulfide bonds in cyclic peptides
    Publication number: 20050239695
    Abstract: A non-oxidative process is described for the formation of an intramolecular disulfide bond in precursors of the peptide or peptidomimetic type; said process comprises the preparation of a linear intermediate containing an —SH group in the S-sulfonate form and a second —SH group which is obtainable in the free form by means of acid treatment.
    Type: Application
    Filed: April 26, 2005
    Publication date: October 27, 2005
    Applicant: CHEMI SPA, Cinisello Balsamo
    Inventors: Silvana Cappelletti, Olivia Storace, Paola Annoni, Massimo Pinori
  • Oligopeptides derived from C-reactive protein fragments
    Patent number: 6057295
    Abstract: Oligopeptides derived from fragments of C-reactive proteins and their use as immunomodulating agents in the therapy of cardiovascular and inflammatory diseases.
    Type: Grant
    Filed: June 11, 1996
    Date of Patent: May 2, 2000
    Assignee: Italfarmaco S.p.A.
    Inventors: Patrizia Caretto, Flavio Leoni, Fabrizio Marcucci, Gianni Gromo, Paolo Mascagni, Massimo Pinori, Silvana Cappelletti
  • Partially modified and retro-inverted tetrapeptides analogues of C-reactive protein fragments
    Patent number: 5578575
    Abstract: A method for treating septic shock by administering a retroinverted tetrapeptides of formula I ##STR1## wherein R is a hydrogen atom or the side-chain of threonine; R.sub.1 is the side-chain of arginine, leucine or glutamine; and R.sub.2 is a hydrogen atom or a metabolically perishable acyl group; with the proviso that when R.sub.1 is the side-chain of arginine, R cannot be the side-chain of threonine; diastereo-isomeric forms and pharmacologically acceptable salts, esters and amides thereof.
    Type: Grant
    Filed: February 28, 1996
    Date of Patent: November 26, 1996
    Assignee: Italfarmaco S.P.A.
    Inventors: Antonio S. Verdini, Massimo Pinori, Silvana Cappelletti, Laura Gazerro, Flavio Leoni
  • Partially modified and retro-inverted tetrapeptides analogues of C-reactive protein fragments
    Patent number: 5521159
    Abstract: Retro-inverted tetrapeptides of formula I ##STR1## wherein R is a hydrogen atom or the side-chain of threonine; R.sub.1 is the side-chain of arginine, leucine or glutamine; and R.sub.2 is a hydrogen atom or a metabolically perishable acyl group; with the proviso that when R.sub.1 is the side-chain of arginine, R cannot be the side-chain of threonine; diastereo-isomeric forms and pharmacologically acceptable salts, esters and amides thereof. These compounds are useful as immuno-stimulating agents.
    Type: Grant
    Filed: September 27, 1994
    Date of Patent: May 28, 1996
    Assignee: Italfarmaco S.p.A.
    Inventors: Antonio S. Verdini, Massimo Pinori, Silvana Cappelletti, Laura Gazerro, Flavio Leoni