Patents by Inventor Silvana D'Alessio

Silvana D'Alessio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Metalloproteinase inhibitors, their therapeutic use and process for the production of the starting compound in the synthesis thereof
    Patent number: 6339160
    Abstract: Objects of the present invention are compounds of a peptido-mimetic character having the capacity of acting as inhibitors of metalloproteinases produced by venom of snake, and of other metalloproteinases of human origin which have been put in relation with various pathologies in man, including tumoral growth and metastatization, aterosclerosis, multiple sclerosis, Alzheimer's disease, osteoporosis, hypertension, rheumatoid arthritis and other inflammatory diseases. Object of the present invention is also the procedure for the production of diethylester of (1)-phosphotryptophan, as an initial product necessary to synthesize all compounds mentioned above.
    Type: Grant
    Filed: May 9, 2000
    Date of Patent: January 15, 2002
    Assignees: Polifarma S.p.A., Consiglio Nazionale Delle Ricerche
    Inventors: Vincenzo Politi, Enrico Gavuzzo, Carlo Gallina, Giovanni Di Stazio, Silvana D'Alessio, Antonio Sella, Cinzia Piazza, Cesare Giordano, Barbara Gorini, Gabriella Panini, Mario Paglialunga Paradisi, Maurizio Cirilli, Giorgio Pochetti, Fernando Mazza
  • Inhibitor compounds of zinc-dependent metalloproteinases associated with pathological conditions, and therapeutic use thereof
    Patent number: 6057297
    Abstract: Peptidomimetic compounds capable of inhibiting zinc-dependent metalloproteinases to treat pathological conditions associated with activation of endogenous metalloproteinases in mammals.
    Type: Grant
    Filed: March 18, 1998
    Date of Patent: May 2, 2000
    Assignee: Polifarma S.p.A.
    Inventors: Vincenzo Politi, Silvana D'Alessio, Giovanni Di Stazio, Giovanna De Luca, Mario Materazzi
  • Method for determining the therapeutic activity of metalloproteinase inhibitor compounds
    Patent number: 5846755
    Abstract: A method for determining the therapeutic potential of peptidomimetic compounds as inhibitors of zinc-dependent metalloproteinase activity associated with pathological conditions of humans and animals.
    Type: Grant
    Filed: August 6, 1996
    Date of Patent: December 8, 1998
    Assignee: Polifarma S.p.A.
    Inventors: Vencenzo Politi, Silvana D'Alessio, Giovanni Di Stazio, Giovanna De Luca, Mario Materazzi