Patents by Inventor Silvana OPP

Silvana OPP has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MODIFIED ALPHAVIRUS FOR USE AS COVID-19 VACCINE
    Publication number: 20230218745
    Abstract: Modified alphaviruses encoding a SARS-CoV-2 spike protein or antigenic segment of the SARS-CoV-2 spike protein are provided. The modified alphaviruses include replicative defective Sindbis viruses. The modified viruses express or are administered with an immunomodulatory agent that is an agonist antibody or antigenbinding fragment thereof, or a cytokine, or a combination thereof. Pharmaceutical compositions that include the modified alphaviruses and methods of using the modified alphaviruses and compositions that contain them are provided. The compositions are used to stimulate a therapeutic or protective effect against SARS-CoV-2 infection that includes humoral and cell mediated responses.
    Type: Application
    Filed: May 28, 2021
    Publication date: July 13, 2023
    Inventors: Daniel MERUELO, Silvana OPP, Antonella SCAGLIONE, Christine PAMPENO, Alicia Hurtado MARTINEZ, Ziyan LIN
  • TUMOR IMMUNOTHERAPY USING SINDBIS VIRAL VECTORS AND AGONIST MONOCLONAL ANTIBODIES
    Publication number: 20220265820
    Abstract: The present disclosure provides compositions and methods for the treatment of cancer. More specifically, the present disclosure provides compositions and methods utilizing a combination of an oncolytic viruses, such as Sindbis virus, and antibodies directed against a co-stimulatory molecule or to an immune system agonist molecule, such as anti-OX40 antibodies and anti-4-1BB antibodies.
    Type: Application
    Filed: July 8, 2020
    Publication date: August 25, 2022
    Inventors: Daniel MERUELO, Iris SCHERWITZL, Silvana OPP, Minjun YU, Alicia HURTADO-MARTINEZ, Christine PAMPENO