Patents by Inventor Silvia Cainarca

Silvia Cainarca has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Photoproteins with enhanced bioluminescence and assays using the same
    Patent number: 7981602
    Abstract: The present invention relates to photoproteins with enhanced bioluminescence obtained by mutagenesis of clytin, to their use as intracellular calcium indicators and in cell-based assays.
    Type: Grant
    Filed: March 9, 2006
    Date of Patent: July 19, 2011
    Assignee: AXXAM S.R.L.
    Inventors: Nadia Mastroianni, Silvia Cainarca, Sabrina Corazza
  • LUMINESCENT STEM CELLS AND USES THEREOF
    Publication number: 20090286695
    Abstract: It is described a stable recombinant stem cell able to express an apophotoprotein and produce a bioluminescent signal in the presence of a suitable chromophore as substrate in response to intracellular calcium concentration variation: methods for identifying agents modulating the differentiation of stem cells towards a specific cell lineage; methods for identifying a ligand able to stimulate a specific cell lineage target; methods for identifying an antagonist to ligand known to stimulate a specific cell lineage target uses of stable recombinant stem cells for in vitro testing of toxicity and/teratology of a substance.
    Type: Application
    Filed: January 10, 2007
    Publication date: November 19, 2009
    Applicant: AXXAM S.P.A.
    Inventors: Silvia Cainarca, Cinzia Nucci, Sabrina Corazza, Stefan Lohmer
  • Photoproteins With Enhanced Bioluminescence And Assays Using The Same
    Publication number: 20070259389
    Abstract: The present invention relates to photoproteins with enhanced bioluminescence obtained by mutagenesis of clytin, to their use as intracellular calcium indicators and in cell-based assays.
    Type: Application
    Filed: March 9, 2006
    Publication date: November 8, 2007
    Applicant: AXXAM S.R.L.
    Inventors: Nadia Mastroianni, Silvia Cainarca, Sabrina Corazza