Patents by Inventor Silvia Gravina

Silvia Gravina has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Charge-tagged nucleotides and methods of use thereof
    Patent number: 11578094
    Abstract: Provided is a method including detecting an incorporation of a labelled nucleotide into a nascent polynucleotide strand complementary to a template polynucleotide strand by a polymerase, wherein the polymerase is tethered to a solid support conductive channel by a tether and the labelled nucleotides is a compound of Formula I:
    Type: Grant
    Filed: November 30, 2020
    Date of Patent: February 14, 2023
    Assignees: ILLUMINA, INC., ILLUMINA SINGAPORE PTE. LTD.
    Inventors: Jeffrey Mandell, Silvia Gravina, Sergio Peisajovich, Kaitlin Pugliese, Yin Nah Teo, Xiangyuan Yang, Maria Candelaria Rogert Bacigalupo
  • ATTACHING NUCLEOTIDES TO A POLYNUCLEOTIDE WITH A POLYMERASE
    Publication number: 20220090193
    Abstract: Provided is a method including hybridizing a polynucleotide to a template, contacting a first template nucleotide 5-prime adjacent to a 5-prime-most nucleotide of the plurality of nucleotides that are complementary to the polynucleotide with a polymerase and a charge-tagged nucleotide, wherein the charge-tagged nucleotide is complementary to the first template nucleotide and includes a charge tag attached to a 5-prime polyphosphate of the charge-tagged nucleotide.
    Type: Application
    Filed: August 18, 2020
    Publication date: March 24, 2022
    Applicants: ILLUMINA, INC., ILLUMINA SINGAPORE PTE. LTD.
    Inventors: Yannan ZHAO, Kaitlin PUGLIESE, Erin GARCIA, Ludovic VINCENT, Anmiv PRABHU, Silvia GRAVINA, Sergio PEISAJOVICH, Yin Nah TEO, Xiangyuan YANG, Jeffrey MANDELL, Jonathon STUTCHMAN
  • DEVICE, KIT AND METHOD FOR COLLECTING ENDOCERVICAL AND VAGINAL SAMPLES
    Publication number: 20220061821
    Abstract: The present disclosure provides a device for collection of an endocervical or vaginal sample, as well as a method of using the device to collect a sample a subject and perform an assay. The collection device includes a resiliently deformable ring, a flexible membrane coupled to the ring which defines a collection reservoir, and a retrieval element configured for removal of the device.
    Type: Application
    Filed: August 25, 2021
    Publication date: March 3, 2022
    Inventors: Tristan Orpin, Richard Shippy, Silvia Gravina
  • CHARGE-TAGGED NUCLEOTIDES AND METHODS OF USE THEREOF
    Publication number: 20210179657
    Abstract: Provided is a method including detecting an incorporation of a labelled nucleotide into a nascent polynucleotide strand complementary to a template polynucleotide strand by a polymerase, wherein the polymerase is tethered to a solid support conductive channel by a tether and the labelled nucleotides is a compound of Formula I:
    Type: Application
    Filed: November 30, 2020
    Publication date: June 17, 2021
    Applicants: ILLUMINA, INC., ILLUMINA SINGAPORE PTE. LTD.
    Inventors: Jeffrey MANDELL, Silvia GRAVINA, Sergio PEISAJOVICH, Kaitlin PUGLIESE, Yin Nah TEO, Xiangyuan YANG, Maria Candelaria Rogert BACIGALUPO
  • Charge-tagged nucleotides and methods of use thereof
    Patent number: 10851131
    Abstract: Provided is a method including detecting an incorporation of a labelled nucleotide into a nascent polynucleotide strand complementary to a template polynucleotide strand by a polymerase, wherein the polymerase is tethered to a solid support conductive channel by a tether and the labelled nucleotides is a compound of Formula I:
    Type: Grant
    Filed: February 19, 2019
    Date of Patent: December 1, 2020
    Assignees: ILLUMINA, INC., ILLUMINA SINGAPORE PTE. LTD.
    Inventors: Jeffrey Mandell, Silvia Gravina, Sergio Peisajovich, Kaitlin Pugliese, Yin Nah Teo, Xiangyuan Yang, Maria Candelaria Rogert Bacigalupo
  • CHARGE-TAGGED NUCLEOTIDES AND METHODS OF USE THEREOF
    Publication number: 20200123193
    Abstract: Provided is a method including detecting an incorporation of a labelled nucleotide into a nascent polynucleotide strand complementary to a template polynucleotide strand by a polymerase, wherein the polymerase is tethered to a solid support conductive channel by a tether and the labelled nucleotides is a compound of Formula I:
    Type: Application
    Filed: February 19, 2019
    Publication date: April 23, 2020
    Applicants: ILLUMINA, INC., ILLUMINA SINGAPORE PTE. LTD.
    Inventors: Jeffrey MANDELL, Silvia GRAVINA, Sergio PEISAJOVICH, Kaitlin PUGLIESE, Yin Nah TEO, Xiangyuan YANG
  • METHOD FOR MEASURING DNA METHYLATION PROFILES
    Publication number: 20140329692
    Abstract: Methods are provided for determining epimutations in a nucleic acid sequence of a cell.
    Type: Application
    Filed: April 16, 2014
    Publication date: November 6, 2014
    Applicant: ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY
    Inventors: Jan Vijg, Silvia Gravina