Patents by Inventor Silvia M. Uriarte

Silvia M. Uriarte has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INHIBITION OF DEGRANULATION OF NEUTROPHIL CELLS IN COVID-19 PATIENTS
    Publication number: 20240092834
    Abstract: In certain aspects, provided herein are methods of inhibiting neutrophil degranulation in a patient infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by administering a composition comprising (a) a TAT-fusion protein comprising an 11 amino acid cell penetrating peptide TAT operably linked to an N-terminal SNARE domain of SNAP-23 (TAT-SNAP-23), and/or a TAT-fusion protein comprising an 11 amino acid cell penetrating peptide TAT operably linked to a SNARE domain of syn-taxin-4 (TAT-STX-4), wherein the inhibition is compared to a control.
    Type: Application
    Filed: January 25, 2022
    Publication date: March 21, 2024
    Applicant: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
    Inventors: Kenneth R. MCLEISH, Jiapeng HUANG, Madhavi J. RANE, Silvia M. URIARTE, Jun YAN
  • Methods and compositions for inhibition of neutrophil exocytosis
    Patent number: 8709758
    Abstract: Isolated fusion polypeptides are provided that are comprised of a cell-penetrating polypeptide and a SNARE polypeptide aptamer. Further provided are methods for inhibiting neutrophil granule exocytosis that comprise contacting a neutrophil with a fusion polypeptide including a cell-penetrating polypeptide and a SNARE polypeptide aptamer such that the fusion polypeptide enters the neutrophil and inhibits neutrophil granule exocytosis. Also provided are methods for treating a neutrophil-mediated inflammatory disorder by inhibiting SNARE-associated exocytosis in neutrophils.
    Type: Grant
    Filed: July 28, 2009
    Date of Patent: April 29, 2014
    Assignee: University of Louisville Research Foundation, Inc.
    Inventors: Kenneth R. McLeish, Silvia M. Uriarte, Madhavi J. Rane
  • METHODS AND COMPOSITIONS FOR INHIBITION OF NEUTROPHIL EXOCYTOSIS
    Publication number: 20110178020
    Abstract: Isolated fusion polypeptides are provided that are comprised of a cell-penetrating polypeptide and a SNARE polypeptide aptamer. Further provided are methods for inhibiting neutrophil granule exocytosis that comprise contacting a neutrophil with a fusion polypeptide including a cell-penetrating polypeptide and a SNARE polypeptide aptamer such that the fusion polypeptide enters the neutrophil and inhibits neutrophil granule exocytosis. Also provided are methods for treating a neutrophil-mediated inflammatory disorder by inhibiting SNARE-associated exocytosis in neutrophils.
    Type: Application
    Filed: July 28, 2009
    Publication date: July 21, 2011
    Applicant: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
    Inventors: Kenneth R. McLeish, Silvia M. Uriarte, Madhavi J. Rane