Abstract: Disclosed are trilaminate collagen-based tissue scaffolds that exhibit remarkable morphological mimicry to that of the natural mammalian periosteum tissue they are useful in remodeling. In particular embodiments, periosteum-modeling trizonal membranes for reforming and regrowing human bone tissue are provided that are composed of a first zone of compact collagen, a second layer of collagen-elastin, and a third layer of biomineralized collagen.

Abstract: Disclosed are biocompatible, biodegradable, implantable devices for the controlled release of bioactive molecules. In particular embodiments, nanotechnology-based tunable implants are disclosed for 1) localized delivery of analgesics to treat postoperative pain; 2) sustained delivery of growth factors to promote vascularization; and 3) directing tissue regeneration, including the self-direction of autologous stem cells for organ remodeling.