Patents by Inventor Silvia Zucchelli

Silvia Zucchelli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Functional nucleic acid molecule and use thereof
    Patent number: 11649456
    Abstract: There is disclosed a trans-acting functional nucleic acid molecule comprising a eukaryotic target binding sequence comprising a sequence reverse complementary to a target mRNA sequence for which protein translation is to be enhanced, and a regulatory sequence comprising an internal ribosome entry site (IRES) sequence or an internal ribosome entry site (IRES) derived sequence and enhancing translation of the target mRNA sequence, wherein the regulatory sequence is located 3? of the target binding sequence.
    Type: Grant
    Filed: September 20, 2018
    Date of Patent: May 16, 2023
    Assignees: FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA, SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI
    Inventors: Stefano Gustincich, Silvia Zucchelli
  • FUNCTIONAL NUCLEIC ACID MOLECULES UPREGULATING THE TRANSLATION OF A FRATAXIN MRNA
    Publication number: 20220259595
    Abstract: There are disclosed functional nucleic acid molecules comprising at least one target binding sequence comprising a sequence reverse complementary to a frataxin mRNA sequence; and a regulatory sequence comprising a SINE B2 element or a functionally active fragment of a SINE B2 element or an internal ribosome entry site (IRES) sequence or an IRES derived sequence.
    Type: Application
    Filed: July 10, 2020
    Publication date: August 18, 2022
    Inventors: Stefano Gustincich, Silvia Zucchelli (deceases), Carlotta Bon
  • STRUCTURAL DOMAINS OF ANTISENSE RNA MOLECULES UP-REGULATING TRANSLATION
    Publication number: 20210139898
    Abstract: There are disclosed functional nucleic acid molecules comprising a target binding sequence comprising a sequence reverse complementary to a target mRNA sequence for which protein translation is to be enhanced; and a regulatory sequence having two-dimensional structures comprising specific stem-loop and internal loop domains and displaying translation enhancing efficiency.
    Type: Application
    Filed: February 5, 2019
    Publication date: May 13, 2021
    Applicants: Scuola Internazionale Superiore Di Studi Avanzati ? SISSA, TranSINE Therapeutics Limited
    Inventors: Stefano GUSTINCICH, Silvia ZUCCHELLI, Peter PODBEVSEK, Janez PLAVEC, Piero CARNINCI, Hazuki TAKAHASHI, Toshio YAMAZAKI, Takako OHYAMA, Harshita SHARMA
  • FUNCTIONAL NUCLEIC ACID MOLECULE AND USE THEREOF
    Publication number: 20200224197
    Abstract: There is disclosed a trans-acting functional nucleic acid molecule comprising a eukaryotic target binding sequence comprising a sequence reverse complementary to a target mRNA sequence for which protein translation is to be enhanced, and a regulatory sequence comprising an internal ribosome entry site (IRES) sequence or an internal ribosome entry site (IRES) derived sequence and enhancing translation of the target mRNA sequence, wherein the regulatory sequence is located 3? of the target binding sequence.
    Type: Application
    Filed: September 20, 2018
    Publication date: July 16, 2020
    Applicants: FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA, SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI
    Inventors: Stefano GUSTINCICH, Silvia ZUCCHELLI
  • ENDOTHELIAL-SPECIFIC PROMOTER SEQUENCES AND USES THEREOF
    Publication number: 20200165631
    Abstract: Sequences derived from Stabilin-2 promoter are used as a promoter to drive the expression of a gene specifically into endothelial cells, preferably said gene is a therapeutic gene, such as FVIII or any gene involved in the coagulation cascade. Moreover, the use of these sequences is for medical purposes, in particular, to treat a genetic disease, such as hemophilia, preferably by gene and/or cellular therapy.
    Type: Application
    Filed: July 26, 2018
    Publication date: May 28, 2020
    Applicant: UNIVERSITA' DEL PIEMONTE ORIENTALE
    Inventors: Antonia FOLLENZI, Simone MERLIN, Ester BORRONI, Chiara BORSOTTI, Valentina BRUSCAGGIN, Silvia ZUCCHELLI
  • Functional nucleic acid molecule and use thereof
    Patent number: 9353370
    Abstract: The present invention provides (a) a functional nucleic acid molecule comprises: a target determinant sequence comprising antisense sequence to a target sequence in the protein-encoding RNA for which protein synthesis efficiency is to be increased and a regulatory sequence having an activity of increasing of the protein synthesis efficiency, and (b) a use of the functional nucleic acid molecule.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: May 31, 2016
    Assignees: Riken, International School for Advanced Studies
    Inventors: Piero Carninci, Alistair Forrest, Stefano Gustincich, Claudia Carrieri, Silvia Zucchelli
  • FUNCTIONAL NUCLEIC ACID MOLECULE AND USE THEREOF
    Publication number: 20140107187
    Abstract: The present invention provides (a) a functional nucleic acid molecule comprises: a target determinant sequence comprising antisense sequence to a target sequence in the protein-encoding RNA for which protein synthesis efficiency is to be increased and a regulatory sequence having an activity of increasing of the protein synthesis efficiency, and (b) a use of the functional nucleic acid molecule.
    Type: Application
    Filed: March 30, 2012
    Publication date: April 17, 2014
    Applicants: INTERNATIONAL SCHOOL FOR ADVANCED STUDIES, RIKEN
    Inventors: Piero Carninci, Alistair Forrest, Stefano Gustincich, Claudia Carrieri, Silvia Zucchelli