Patents by Inventor Silvio Iera

Silvio Iera has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CRYSTAL FORMS OF 2-(3-FLUORO-4-HYDROXYPHENYL)-7-VINYL-1,3-BENZOXAZOL-5-OL
    Publication number: 20100113541
    Abstract: The present invention is directed to monohydrate and anhydrate crystal forms of 2-(3-fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol, an estrogenic receptor modulator useful in the treatment of, for example, diseases related to abnormal levels of estrogen.
    Type: Application
    Filed: December 18, 2009
    Publication date: May 6, 2010
    Applicant: Wyeth LLC
    Inventors: Abdolsamad TADAYON, Silvio IERA, Hong WEN, Marc S. TESCONI, Mannching Sherry KU
  • Crystalline polymorph of bazedoxifene acetate
    Patent number: 7683051
    Abstract: The present invention is directed to a crystalline polymorph of bazedoxifene acetate, compositions containing the same, preparations thereof, and uses thereof.
    Type: Grant
    Filed: April 6, 2005
    Date of Patent: March 23, 2010
    Assignee: Wyeth
    Inventors: Christopher Demerson, Silvio Iera, Kadum A. Ali
  • Crystal forms of 2-(3-fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol
    Patent number: 7683182
    Abstract: The present invention is directed to monohydrate and anhydrate crystal forms of 2-(3-fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol, an estrogenic receptor modulator useful in the treatment of, for example, diseases related to abnormal levels of estrogen.
    Type: Grant
    Filed: March 6, 2006
    Date of Patent: March 23, 2010
    Assignee: Wyeth LLC
    Inventors: Abdolsamad Tadayon, Silvio Iera, Hong Wen, Marc S. Tesconi, Mannching Sherry Ku
  • Process for the purification of substituted benzoxazole compounds
    Patent number: 7579478
    Abstract: The present invention provides processes for the purification of substituted benzoxazole compounds, and in particular 2-(3-fluoro-4-hydroxy-phenyl)-7-vinyl-benzooxazol-5-ol. The processes include recrystallizing the compound from a solution comprising acetone and acetonitrile; treating the crude purified product with a clarifying agent in a solution comprising ethyl acetate, and precipitating or triturating the compound from a mixed solvent system.
    Type: Grant
    Filed: March 6, 2006
    Date of Patent: August 25, 2009
    Assignee: Wyeth
    Inventor: Silvio Iera
  • Process for the synthesis of derivatives of halo-[2,3-F] quinoline
    Patent number: 7439364
    Abstract: Methods of preparing compounds of Formula I are provided.
    Type: Grant
    Filed: December 4, 2006
    Date of Patent: October 21, 2008
    Assignee: Wyeth
    Inventors: Anita W. Chan, Timothy T. Curran, Silvio Iera, Warren Chew, John H. Sellstedt, Galina Vid, Greg Feigelson, Zhixian Ding
  • CRYSTAL FORM OF 2-(3-FLUORO-4-HYDROXYPHENYL)-7-VINYL-1,3-BENZOXAZOL-5-OL
    Publication number: 20080176914
    Abstract: The present invention is directed to an anhydrate crystal form (designated as Form B herein) of 2-(3-fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol, an estrogenic receptor modulator useful in the treatment of, for example, diseases related to abnormal levels of estrogen.
    Type: Application
    Filed: November 20, 2007
    Publication date: July 24, 2008
    Applicant: WYETH
    Inventors: Abdolsamad TADAYON, Silvio IERA, Mahmoud MIRMEHRABI
  • CRYSTAL FORM OF 2-(3-FLUORO-4-HYDROXYPHENYL)-7-VINYL-1,3-BENZOXAZOL-5-OL
    Publication number: 20080146630
    Abstract: The present invention is directed to an anhydrate crystal form (designated as Form E herein) of 2-(3-fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol, an estrogenic receptor modulator useful in the treatment of, for example, diseases related to abnormal levels of estrogen.
    Type: Application
    Filed: November 20, 2007
    Publication date: June 19, 2008
    Applicant: WYETH
    Inventors: Abdolsamad Tadayon, Silvio Iera, Mahmoud Mirmehrabi
  • Process for the Synthesis of Monosulfated Derivatives of Substituted Benzoxazoles
    Publication number: 20080139820
    Abstract: The present invention provides synthetic processes for the preparation of mono-sulfated derivatives of substituted benzoxazoles, which are useful as estrogenic agents.
    Type: Application
    Filed: November 29, 2007
    Publication date: June 12, 2008
    Applicant: WYETH
    Inventors: Youchu WANG, Silvio IERA, Maria PAPAMICHELAKIS
  • CRYSTAL FORM OF 2-(3-FLUORO-4-HYDROXYPHENYL)-7-VINYL-1,3-BENZOXAZOL-5-OL
    Publication number: 20080139633
    Abstract: The present invention is directed to a hydrate crystal form (designated as Form F herein) of 2-(3-fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol, an estrogenic receptor modulator useful in the treatment of, for example, diseases related to abnormal levels of estrogen.
    Type: Application
    Filed: November 20, 2007
    Publication date: June 12, 2008
    Applicant: WYETH
    Inventors: Abdolsamad Tadayon, Silvio Iera, Mahmoud Mirmehrabi
  • Process for the Synthesis of Monosulfated Derivatives of Substituted Benzoxazoles
    Publication number: 20080139819
    Abstract: The present invention provides synthetic processes for the preparation of mono-sulfated derivatives of substituted benzoxazoles, which are useful as estrogenic agents.
    Type: Application
    Filed: November 29, 2007
    Publication date: June 12, 2008
    Applicant: WYETH
    Inventors: Youchu WANG, Silvio IERA, Maria PAPAMICHELAKIS
  • CRYSTAL FORM OF 2-(3-FLUORO-4-HYDROXYPHENYL)-7-VINYL-1,3-BENZOXAZOL-5-OL
    Publication number: 20080132554
    Abstract: The present invention is directed to an anhydrate crystal form (Form D) of 2-(3-fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol, an estrogenic receptor modulator useful in the treatment of, for example, diseases related to abnormal levels of estrogen.
    Type: Application
    Filed: November 20, 2007
    Publication date: June 5, 2008
    Applicant: WYETH
    Inventors: Abdolsamad TADAYON, Silvio IERA, Mahmoud MIRMEHRABI
  • POLYMORPHS OF 5-CYCLOPROPYL-2-(4-FLUOROPHENYL)-6-[(2-HYDROXYETHYL)(METHYLSUFONYL)AMINO]-N-METHYL-1-BENZOFURAN-3-CARBOXAMIDE AND METHODS OF MAKING THE SAME
    Publication number: 20070265335
    Abstract: Substantially pure polymorphic forms of 5-cyclopropyl-2-(4-fluorophenyl)-6-[(2-hydroxyethyl)(methylsulfonyl)amino]-N-methyl-1-benzofuran-3-carboxamide are produced by recrystallization in an organic solvent.
    Type: Application
    Filed: November 9, 2006
    Publication date: November 15, 2007
    Applicants: WYETH, VIROPHARMA INCORPORATED
    Inventors: WEIGUO LIU, QIUXIA WANG, WEI TONG, PANOLIL RAVEENDRANATH, SILVIO IERA
  • Process for the Synthesis of Derivatives of 2,3-Dihydro-1,4-Dioxino-[2,3-f] Quinolines
    Publication number: 20070123705
    Abstract: Methods of preparing compounds of Formula I are provided.
    Type: Application
    Filed: December 4, 2006
    Publication date: May 31, 2007
    Applicant: Wyeth
    Inventors: Anita Chan, Timothy Curran, Silvio Iera, Warren Chew, John Sellstedt, Galina Vid, Gregg Feigelson, Zhixian Ding
  • Process for the synthesis of derivatives of 2,3-dihydro-1,4-dioxino-[2,3-f] quinoline
    Patent number: 7166723
    Abstract: Methods of preparing compounds of Formula I are provided.
    Type: Grant
    Filed: November 18, 2005
    Date of Patent: January 23, 2007
    Assignee: Wyeth
    Inventors: Anita Wai-Yin Chan, Timothy T. Curran, Silvio Iera, Warren Chew, John Hamilton Sellstedt, Galina Vid, Gregg Feigelson, Zhixian Ding
  • Synthesis of 4-(amino)-2-butenoyl chlorides and their use in the preparation of 3-cyano quinolines
    Patent number: 7126025
    Abstract: This invention provides a compound of Formula (I): wherein S1 and S2 are each independently, hydrogen, alkyl, alkenyl, alkynyl, aralkyl, substituted or unsubstituted aryl, and S1 and S2 together with the nitrogen to which they are attached form a nitrogen containing heteroaryl and a pharmaceutically acceptable salt thereof; a method of preparing the compound of Formula (I), and use of the compound of Formula (I) in the preparation of 3-cyano quinolines.
    Type: Grant
    Filed: January 15, 2004
    Date of Patent: October 24, 2006
    Assignee: Wyeth
    Inventors: John Leo Considine, Sylvain Daigneault, Warren Chew, Silvio Iera, Scott Mason Duncan, Jianxin Ren
  • Quinoxaline dihydrohalide dihydrates and synthetic methods therefor
    Publication number: 20060211699
    Abstract: Crystalline polymorph forms of Gonadotropin Releasing Hormone receptor antagonists, including crystalline polymorphs of quinoxaline dihydrohalide dihydrates, in particular crystalline polymorphs of 6-({4-[2-(4-tert-butylphenyl)-1H-benzimidazol-4-yl]-piperazin-1-yl}methyl)-quinoxaline dihydrochloride dihydrate, methods of making the same, as well as pharmaceutical compositions, and dosage forms containing them are disclosed.
    Type: Application
    Filed: March 7, 2006
    Publication date: September 21, 2006
    Applicant: Wyeth
    Inventors: Silvio Iera, Abdolsamad Tadayon, John Sellstedt, Subodh Deshmukh
  • Crystal forms of 2-(3-Fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazole-5-ol
    Publication number: 20060205798
    Abstract: The present invention is directed to monohydrate and anhydrate crystal forms of 2-(3-fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol, an estrogenic receptor modulator useful in the treatment of, for example, diseases related to abnormal levels of estrogen.
    Type: Application
    Filed: March 6, 2006
    Publication date: September 14, 2006
    Applicant: Wyeth
    Inventors: Abdolsamad Tadayon, Silvio Iera, Hong Wen, Marc Tesconi, Mannching Ku
  • Process for the purification of substituted benzoxazole compounds
    Publication number: 20060199967
    Abstract: The present invention provides processes for the purification of substituted benzoxazole compounds, and in particular 2-(3-fluoro-4-hydroxy-phenyl)-7-vinyl-benzooxazol-5-ol. The processes include recrystallizing the compound from a solution comprising acetone and acetonitrile; treating the crude purified product with a clarifying agent in a solution comprising ethyl acetate, and precipitating or triturating the compound from a mixed solvent system.
    Type: Application
    Filed: March 6, 2006
    Publication date: September 7, 2006
    Applicant: Wyeth
    Inventor: Silvio Iera
  • Antineoplastic combinations
    Patent number: RE41084
    Abstract: This invention provides the use of a combination of CCI-779 and EKB-569 in the treatment of neoplasms.
    Type: Grant
    Filed: December 22, 2006
    Date of Patent: January 19, 2010
    Assignee: Wyeth
    Inventors: John Leo Considine, Sylvain Daigneault, Warren Chew, Silvio Iera, Scott Duncan, Jiaxen Ren
  • Antineoplastic combinations
    Patent number: RE41253
    Abstract: This invention provides the use of a combination of CCI-779 and EKB-569 in the treatment of neoplasms.
    Type: Grant
    Filed: October 26, 2007
    Date of Patent: April 20, 2010
    Assignee: Wyeth
    Inventors: John Leo Considine, Sylvain Daigneault, Warren Chew, Silvio Iera, Scott Duncan, Jiaxin Ren