Patents by Inventor Silvo Zupan{haeck over (c)}i{haeck over (c)}

Silvo Zupan{haeck over (c)}i{haeck over (c)} has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of simvastatin and derivatives thereof
    Patent number: 6252091
    Abstract: A process for the preparation of compounds of formula (I) wherein R is a C1 to C12 alkyl group and R1 is a protecting group or H which process comprises (a) converting the diol lactone of formula (II) to the protected diol lactone of formula (IIa) wherein R1 is a protecting group (b) acylating the protected diol lactone (IIa) to give compound (I) wherein R1 is a protecting group, (c) optionally removing the protecting group R1 to give compound (I) wherein R1 is H; and wherein steps (a) and/or (b) are carried out in the presence of N-methylimidazole.
    Type: Grant
    Filed: September 22, 2000
    Date of Patent: June 26, 2001
    Assignee: KRKA, Tovarna Zdravil, D.D.
    Inventors: Silvo Zupan{haeck over (c)}i{haeck over (c)}, Anton Stimac, Jo{haeck over (z)}e Gnidovec