Patents by Inventor Silvo Zupancic

Silvo Zupancic has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR THE PREPARATION OF CANDESARTAN CILEXETIL
    Publication number: 20120029201
    Abstract: The present invention provides an improved synthesis for the manufacture of candesartan and pharmaceutically acceptable salts and esters thereof as active ingredients of a medicament for the treatment of hypertension and related diseases and conditions which comprises the removal of the tetrazolyl protecting group in an organic solvent, and in the presence of a Lewis acid.
    Type: Application
    Filed: October 6, 2011
    Publication date: February 2, 2012
    Inventor: Silvo Zupancic
  • Process for the preparation of olmesartan medoxomil
    Patent number: 7943779
    Abstract: The present invention relates to an improved process for the manufacture of olmesartan and pharmaceutically acceptable salts and esters thereof as an active ingredient of a medicament for the treatment of hypertension and related diseases and conditions.
    Type: Grant
    Filed: July 27, 2006
    Date of Patent: May 17, 2011
    Assignee: KRKA
    Inventors: Silvo Zupancic, Anica Pecavar, Miha Vrbinc, Renata Osolnik
  • SOLID PHARMACEUTICAL COMPOSITION COMPRISING IRBESARTAN
    Publication number: 20110045097
    Abstract: The present invention concerns preferably surfactant-free solid pharmaceutical formulations comprising, as an active ingredient, at least one of irbesartan and pharmaceutically acceptable salts thereof, and at least one disintegrant. Preferably, the active ingredient comprises irbesartan hydrochloride. Also, the present invention is directed to a process for the manufacture of such formulations, including a wet granulation process (A) and a direct granulation process (B).
    Type: Application
    Filed: January 5, 2007
    Publication date: February 24, 2011
    Applicant: KRKA, d.d. Novo mesto
    Inventors: Miha Vrbinc, Renata Jakse, Franci Bevec, Silvo Zupancic
  • Process for the preparation of candesartan cilexetil
    Patent number: 7884212
    Abstract: The present invention provides an improved synthesis for the manufacture of candesartan and pharmaceutically acceptable salts and esters thereof as active ingredients of a medicament for the treatment of hypertension and related diseases and conditions which comprises the removal of the tetrazolyl protecting group in an organic solvent, and in the presence of a Lewis acid.
    Type: Grant
    Filed: September 29, 2006
    Date of Patent: February 8, 2011
    Inventor: Silvo Zupancic
  • Sesquihydrate hydrochloride salt of irbesartan
    Patent number: 7875641
    Abstract: The present invention relates to sesquihydrate hydrochloride salt of irbesartan and pharmaceutical compositions comprising the same.
    Type: Grant
    Filed: July 29, 2005
    Date of Patent: January 25, 2011
    Assignee: KRKA Tovarna Zdravil, D.D., Novo Mesto
    Inventors: Silvo Zupancic, Matej Smrkolj, Renata Jaske
  • Process for the Preparation of Candesartan Cilexetil
    Publication number: 20100197933
    Abstract: The present invention provides an improved synthesis for the manufacture of candesartan and pharmaceutically acceptable salts and esters thereof as active ingredients of a medicament for the treatment of hypertension and related diseases and conditions which comprises the removal of the tetrazolyl protecting group in an organic solvent, and in the presence of a Lewis acid.
    Type: Application
    Filed: April 7, 2010
    Publication date: August 5, 2010
    Inventor: Silvo Zupancic
  • Processes for preparing venlafaxine and venlafaxine hydrochloride of form I
    Patent number: 7745664
    Abstract: A process for preparing venlafaxine in a high yield as well as processes for producing venlafaxine hydrochloride of form I having a very high polymorphic purity are described.
    Type: Grant
    Filed: December 10, 2004
    Date of Patent: June 29, 2010
    Assignee: KRKA Tovarno Zdravil, d.d. Novo Mesto
    Inventor: Silvo Zupancic
  • Processes for preparing venlafaxine and venlafaxine hydrochloride of form I
    Patent number: 7728173
    Abstract: A process for preparing venlafaxine in a high yield as well as processes for producing venlafaxine hydrochloride of form I having a very hight polymorphic purity are described.
    Type: Grant
    Filed: June 4, 2009
    Date of Patent: June 1, 2010
    Assignee: KRKA Tovarna Zdravil, d.d. Novo Mesto
    Inventor: Silvo Zupancic
  • Process for the Preparation of Candesartan Cilexetil
    Publication number: 20090318706
    Abstract: The present invention provides an improved synthesis for the manufacture of candesartan and pharmaceutically acceptable salts and esters thereof as active ingredients of a medicament for the treatment of hypertension and related diseases and conditions which comprises the removal of the tetrazolyl protecting group in an organic solvent, and in the presence of a Lewis acid.
    Type: Application
    Filed: September 29, 2006
    Publication date: December 24, 2009
    Inventor: Silvo Zupancic
  • Processes for Preparing Venlafaxine and Venlafaxine Hydrochloride of Form I
    Publication number: 20090240082
    Abstract: A process for preparing venlafaxine in a high yield as well as processes for producing venlafaxine hydrochloride of form I having a very hight polymorphic purity are described.
    Type: Application
    Filed: June 4, 2009
    Publication date: September 24, 2009
    Inventor: Silvo Zupancic
  • PROCESS FOR THE PREPARATION OF OLMESARTAN MEDOXOMIL
    Publication number: 20090131680
    Abstract: The present invention relates to an improved process for the manufacture of olmesartan and pharmaceutically acceptable salts and esters thereof as an active ingredient of a medicament for the treatment of hypertension and related diseases and conditions.
    Type: Application
    Filed: July 27, 2006
    Publication date: May 21, 2009
    Applicant: KRKA
    Inventors: Silvo Zupancic, Anica Pecavar, Miha Vrbinc, Renata Osolnik
  • Preparation of Hydrochloride Salts of Tetrazole Derivative
    Publication number: 20080306128
    Abstract: The present invention relates to sesquihydrate hydrochloride salt of irbesartan and anhydrous hydrochloride salts of irbesartan. Irbesartan used as the starting material for the preparation of the described hydrochlorides of irbesartan can be in any form, e.g. it can be used when contained in a reaction solution, in crude form, in a filtrate containing several solvents, or in anhydrous or any solvated or hydrated form, in amorphous form or any known crystal form or in a mixture thereof.
    Type: Application
    Filed: July 29, 2005
    Publication date: December 11, 2008
    Inventors: Silvo Zupancic, Matej Smrkolj, Renata Jaske
  • Solid Pharmaceutical Composition Comprising Valsartan
    Publication number: 20080102120
    Abstract: This invention relates to a solid pharmaceutical composition containing valsartan particles characterized in that the D50 of said valsartan particles is 150 ?m or below and that the valsartan particles have a maximum diameter of no more than 1100 ?m, as determined by electron microscopy.
    Type: Application
    Filed: December 23, 2005
    Publication date: May 1, 2008
    Inventors: Miha Vrbinc, Janika Slanc Vovk, Marija Rangus, Silvo Zupancic, Franci Bevec, Lidija Cernosa
  • Processes for preparing venlafaxine and venlafaxine hydrochloride of form I
    Publication number: 20070185354
    Abstract: A process for preparing venlafaxine in a high yield as well as processes for producing venlafaxine hydrochloride of form I having a very high polymorphic purity are described.
    Type: Application
    Filed: December 10, 2004
    Publication date: August 9, 2007
    Applicant: KRKA, TOVARNA ZDRAVIL, D.D. NOVO MESTO
    Inventor: Silvo Zupancic
  • Process for the preparation of 4-oxytetrahydropyran-2-ones
    Patent number: 7094912
    Abstract: A process for the preparation of inhibitors of HMG-CoA reductase, such as simvastatin, from 4-silyloxytetrahydropyran-2-ones with triethylamine trihydrofluoride being used as the desilylation reagent is described. The reaction is performed in organic solvents, a mixture thereof or without solvents. It is characteristic of this reaction that no additional impurities are obtained and that it takes place without the use of additional catalysts and with low excesses of the reagent.
    Type: Grant
    Filed: March 17, 2003
    Date of Patent: August 22, 2006
    Assignee: KRKA, Tovarna Zdravil, D. D.
    Inventors: Silvo Zupancic, Dusan Krasovec, Pavel Zupet
  • Proces for the preparation of 4-oxytetrahydropyran-2-ones
    Publication number: 20050182263
    Abstract: A process for the preparation of inhibitors of HMG-CoA reductase, such as simvastatin, from 4-silyloxytetrahydropyran-2-ones with triethylamine trihydrofluoride being used as the desilylation reagent is described. The reaction is performed in organic solvents, a mixture thereof or without solvents. It is characteristic of this reaction that no additional impurities are obtained and that it takes place without the use of additional catalysts and with low excesses of the reagent.
    Type: Application
    Filed: March 17, 2003
    Publication date: August 18, 2005
    Inventors: Silvo Zupancic, Dusan Krasovec, Pavel Zupet