Patents by Inventor Sim Mui Mui

Sim Mui Mui has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Dihydroorotate dehydrogenase inhibitors for the treatment of viral-mediated diseases
    Patent number: 6841561
    Abstract: Flavivirus, rhabdovirus and paramyxovirus infections may be treated by administering an inhibitor of the enzyme dihydroorotate dehydrogenase such as 6-fluoro-2-(2?-fluoro-1,1?-biphenyl-4-yl)-3-methyl-4-quinolinearcarboxylic acid sodium salt (Brequinar). A synergistic effect can be obtained if an interferon such as interferon ?2, interferon ?8 or interferon ?, or an inhibitor of a second enzyme selected from inosine monophosphate dehydrogenase, guanosine monophosphate synthetase, cytidine triphosphate synthetase and S-adenosylhomocysteine hydrolase, is also administered.
    Type: Grant
    Filed: September 29, 2000
    Date of Patent: January 11, 2005
    Assignee: Institute of Molecular and Cell Biology
    Inventors: Yin Hwee Tan, John Stanford Driscoll, Sim Mui Mui