Patents by Inventor Sima Lev

Sima Lev has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD OF DIAGNOSING BREAST CANCER
    Publication number: 20230273211
    Abstract: A method of diagnosing breast cancer is disclosed. The method comprises lysing extracellular vesicles of a subject to generate a composition comprising components of extracellular vesicles; measuring the amount of MEK1 in the composition; and diagnosing the subject with breast cancer when a level of said MEK1 in said composition is above a predetermined threshold. Kits for breast cancer diagnosis are also disclosed.
    Type: Application
    Filed: March 30, 2023
    Publication date: August 31, 2023
    Applicants: Yeda Research and Development Co. Ltd., Tel HaShomer Medical Research Infrastructure and Services Ltd.
    Inventors: Sima LEV, Yaron VINIK, Francisco Gabriel ORTEGA, Mordechai GUTMAN MD
  • PYK2 related products and methods
    Publication number: 20040005648
    Abstract: The present invention features a method for treatment of an organism having a disease or condition characterized by an abnormality in a signal transduction pathway, wherein the signal transduction pathway includes a PYK2 protein. The invention also features methods for diagnosing such diseases and for screening for agents that will be useful in treating such diseases. The invention also features purified and/or isolated nucleic acid encoding a PYK2 protein.
    Type: Application
    Filed: June 19, 2003
    Publication date: January 8, 2004
    Applicants: Sugen, Inc., New York University
    Inventors: Sima Lev, Joseph Schlessinger
  • PYK2 related products and methods
    Publication number: 20030119067
    Abstract: The present invention features a method for treatment of an organism having a disease or condition characterized by an abnormality in a signal transduction pathway, wherein the signal transduction pathway includes a PYK2 protein. The invention also features methods for diagnosing such diseases and for screening for agents that will be useful in treating such diseases. The invention also features purified and/or isolated nucleic acid encoding a PYK2 protein.
    Type: Application
    Filed: November 13, 2002
    Publication date: June 26, 2003
    Applicant: Sugen, Inc.
    Inventors: Sima Lev, Joseph Schlessinger
  • rdgB proteins and related products and methods
    Patent number: 6576442
    Abstract: The present invention features a method for treatment of an organism having a disease or condition characterized by an abnormality in a signal transduction pathway, wherein the signal transduction pathway includes a rdgB protein. The invention also features methods for diagnosing such diseases and for screening for agents that will be useful in treating such diseases. The invention also features purified and/or isolated nucleic acid encoding a rdgB protein.
    Type: Grant
    Filed: June 7, 2000
    Date of Patent: June 10, 2003
    Assignees: Sugen, Inc., New York University Medical Center
    Inventors: Sima Lev, Gregory D. Plowman, Joseph Schlessinger
  • PYK2 RELATED PRODUCTS AND METHODS
    Publication number: 20020048782
    Abstract: The present invention features a method for treatment of an organism having a disease or condition characterized by an abnormality in a signal transduction pathway, wherein the signal transduction pathway includes a PYK2 protein. The invention also features methods for diagnosing such diseases and for screening for agents that will be useful in treating such diseases. The invention also features purified and/or isolated nucleic acid encoding a PYK2 protein.
    Type: Application
    Filed: December 9, 1997
    Publication date: April 25, 2002
    Inventors: SIMA LEV, JOSEPH SCHLESSINGER
  • RDGB proteins and related products and methods
    Patent number: 6117673
    Abstract: The present invention features a method for treatment of an organism having a disease or condition characterized by an abnormality in a signal transduction pathway, wherein the signal transduction pathway includes a rdgB protein. The invention also features methods for diagnosing such diseases and for screening for agents that will be useful in treating such diseases. The invention also features purified and/or isolated nucleic acid encoding a rdgB protein.
    Type: Grant
    Filed: September 26, 1997
    Date of Patent: September 12, 2000
    Assignee: Sugen, Inc.
    Inventors: Sima Lev, Gregory D. Plowman, Joseph Schlessinger
  • PYK2 related polypeptide products
    Patent number: 5837815
    Abstract: The present invention features a method for treatment of an organism having a disease or condition characterized by an abnormality in a signal transduction pathway, wherein the signal transduction pathway include a PYK2 protein. The invention also features methods for diagnosing such diseases and for screening for agents that will be useful in treating such diseases. The invention also features purified and/or isolated nucleic acid encoding a PYK2 protein.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: November 17, 1998
    Assignee: Sugen, Inc.
    Inventors: Sima Lev, Joseph Schlessinger
  • PYK2 related polynucleotide products
    Patent number: 5837524
    Abstract: The present invention features a method for treatment of an organism having a disease or condition characterized by an abnormality in a signal transduction pathway, wherein the signal transduction pathway includes a PYK2 protein. The invention also features methods for diagnosing such diseases and for screening for agents that will be useful in treating such diseases, The invention also feature purified and/or isolated nucleic acid encoding a PYK2 protein.
    Type: Grant
    Filed: December 15, 1994
    Date of Patent: November 17, 1998
    Assignees: Sugen, Inc., New York University
    Inventors: Joseph Schlessinger, Sima Lev