Patents by Inventor Sima Zacharek

Sima Zacharek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • USE OF MRNA ENCODING OX40L TO TREAT CANCER IN HUMAN PATIENTS
    Publication number: 20220001026
    Abstract: The disclosure features methods for treating ovarian cancer, as well as other cancers such as solid tumors, lymphomas and epithelial origin cancers, by administering mRNA encoding an OX40L polypeptide. The disclosure also features compositions for use in the methods. The disclosure also features combination therapies, such as use of mRNA encoding an OX40L polypeptide in combination with a checkpoint inhibitor, such as an anti-PD-L1 antibody.
    Type: Application
    Filed: November 8, 2019
    Publication date: January 6, 2022
    Inventors: Robert MEEHAN, Sima ZACHAREK, Kristen HOPSON, Joshua P. FREDERICK
  • Compositions and methods for identification, assessment, prevention, and treatment of cancer using NFS1 biomarkers and modulators
    Patent number: 10947596
    Abstract: The present invention is based, in part, on the identification, of novel mitochondrial iron-sulfur (Fe—S) cluster biosynthesis pathway biomarkers and modulators, and methods of use thereof, for identifying, assessing, preventing, and treating cancer.
    Type: Grant
    Filed: May 6, 2015
    Date of Patent: March 16, 2021
    Assignee: Dana-Farber Cancer Institute, Inc.
    Inventors: Mark Bittinger, Jessie M. English, Kwok-Kin Wong, Sima Zacharek
  • COMPOSITIONS AND METHODS FOR IDENTIFICATION, ASSESSMENT, PREVENTION, AND TREATMENT OF CANCER USING NFS1 BIOMARKERS AND MODULATORS
    Publication number: 20170051358
    Abstract: The present invention is based, in part, on the identification, of novel mitochondrial iron-sulfur (Fe—S) cluster biosynthesis pathway biomarkers and modulators, and methods of use thereof, for identifying, assessing, preventing, and treating cancer.
    Type: Application
    Filed: May 6, 2015
    Publication date: February 23, 2017
    Inventors: Mark Bittinger, Jessie M. English, Kwok-Kin Wong, Sima Zacharek