Abstract: Disclosed is a discharge streamer simulation method and system considering offset and bifurcation. The system includes a test platform, a high-voltage excitation unit, an optical imaging unit, and a data processing & simulation unit. The data processing & simulation unit comprises a computer system. The computer system's processor is configured to: receive discharge images from the camera; measure, from the images, ranges for bifurcation points and effective electron avalanches; construct and execute a simulation model based on specified physical models. The system integrates physical testing with simulation to accurately describe stochastic streamer behavior, and is applicable to guide the development of insulating medium materials and the design of insulation systems.

Abstract: The present invention provides an A-FABP neutralizing monoclonal antibody or antigen-binding fragment thereof and a preparation method and use thereof, which comprises: complementarity determining regions 1 to 3 of a heavy chain variable region, the amino acid sequences of which are set forth in SEQ ID NOs:1-3, respectively, and/or complementarity determining regions 1-3 of the light chain variable region, the amino acid sequences of which are set forth in SEQ ID NOs:4-6. This monoclonal antibody is highly specific for A-FABP and has no cross-reactivity with human and mouse epidermal FABP and heart FABP; it has a good binding affinity for human A-FABP and mouse A-FABP; and its treatment alleviates MCAO-induced ischemic stroke injury in mice, which is associated with alleviated BBB disruption and reduced activation of pro-inflammatory JNK signaling; treatment of healthy mice for 21 days does not change physiological parameters, indicating its safety.

Abstract: Disclosed is a discharge streamer simulation method considering offset and bifurcation. In the method, an insulating medium is arranged in an electric field environment, the number range of discharge streamer bifurcation points in the insulating medium and the number range of effective electron avalanches generated by each bifurcation are measured, a control equation and a boundary condition for streamer simulation are constructed based on a hydrodynamic drift diffusion model and a bipolar charge carrier model, model parameters corrected based on an electron avalanche development probability theory are introduced in the equation solving process, mathematical description and simulation calculation of a streamer offset and a bifurcation phenomenon are realized, and the electric field distribution and charge distribution accompanying the discharge streamer development process considering offset and bifurcation can be finally obtained.