Abstract: Methods and systems for guiding interventional surgery are provided. The method includes receiving a plurality of intracardiac echocardiography (ICE) images of a target object acquired during a preset period, analyzing of the plurality of ICE images to obtain image analysis results, and generating an interventional surgical plan based on the image analysis results to guide the interventional surgery. This method conducts image analysis on ICE image before puncture to plan the interventional surgery, thus identifying the optimal puncture angle, depth, and timing for the interventional surgery. The method can help conduct real-time detection and tracking of the puncture process, identifying and mitigating potential risks during the surgical process to improve the success rate of the surgery.