Patents by Inventor Siming XU

Siming XU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • EFFECTOR PROTEINS, COMPOSITIONS, SYSTEMS AND METHODS OF USE THEREOF
    Publication number: 20260174899
    Abstract: Provided herein are compositions, systems, and methods comprising effector proteins and uses thereof. These effector proteins may be characterized as engineered CRISPR-associated (Cas) proteins. Various compositions, systems, and methods of the present disclosure may leverage the activities of these effector proteins for the editing, detecting and/or engineering of nucleic acids.
    Type: Application
    Filed: October 17, 2025
    Publication date: June 25, 2026
    Inventors: William Douglass WRIGHT, Adam L. GARSKE, Aaron DELOUGHERY, Shiaki Arnett MINAMI, Lucas Benjamin HARRINGTON, Benjamin Julius RAUCH, Wang-Ting LU, Ishita JAIN, Siming XU, Susan Lorraine PROVIDENZA, Mark DEWITT
  • EFFECTOR PROTEIN COMPOSITIONS AND METHODS OF USE THEREOF FOR MANUFACTURING ENGINEERED HSCS
    Publication number: 20240366678
    Abstract: Provided herein are compositions, systems, and methods for engineering hematopoietic stem cells that engineered by using polypeptides, such as effector proteins, and guide nucleic acids. Also, provided herein are the engineered hematopoietic stem cells, methods of manufacturing such hematopoietic stem cells, and methods of treating a disease or disorder using such hematopoietic stem cells.
    Type: Application
    Filed: May 2, 2024
    Publication date: November 7, 2024
    Inventors: Mark Alan DEWITT, Siming XU, William Douglass WRIGHT, Stepan TYMOSHENKO, Benjamin Julius RAUCH, Wiputra Jaya HARTONO, Aaron DELOUGHERY, Lucas Benjamin HARRINGTON