Abstract: A load cell includes an annular base unit where an axial height of the annular base unit is smaller than a diameter of the annular base unit. The annular base unit has a plurality of mounting portions. A plurality of strain gages are located in the plurality of mounting portions. The annular base unit includes a plurality of sections having a Young's modulus different from the Young's modulus of the material of the base unit.

Abstract: Example computer-implemented methods, media, and systems for rapidly identifying hydrodynamic traps in hydrocarbon reservoirs are disclosed. One example computer-implemented method includes receiving a depth structure map of a geological structure associated with a subsurface reservoir. Multiple pairs of tilt value and tilt azimuth value associated with a fluid contact of the subsurface reservoir are received. A respective set of hydrodynamic traps associated with the subsurface reservoir is determined for each pair of tilt value and tilt azimuth value and based at least on the depth structure map. It is determined that there exist a common subset of hydrodynamic traps from the respective set of hydrodynamic traps of each pair of tilt value and tilt azimuth value. One or more locations of potential wells associated with the subsurface reservoir are identified based at least on the determined common subset of hydrodynamic traps.

Abstract: Example computer-implemented methods, media, and systems for determining a total gross rock volume (GRV) of multiple hydrocarbon reservoir units at a site are disclosed. One example method includes receiving multiple data points with each including an element representing a depth of a location on a structure depth map of a first reservoir unit at a site and another element representing a volume enclosed by the structure depth map and between the location and a closing contour of the first reservoir unit. A function representing a relationship between a GRV of a reservoir unit at the site and a closure height of the reservoir unit is curve fit to the multiple data points. A GRV of each of multiple reservoir units at the site is determined using the function. A total GRV of the multiple reservoir units is determined based on the GRV of each of the multiple reservoir units.

Abstract: Embodiments herein relate to a computer-implemented technique that includes generating, in a first portion of a graphical user interface (GUI), a first graphical element related to reflection seismic data of an area of interest. The technique further includes generating, in a second portion of the GUI, a second graphical element related to well structural data of the area of interest. The technique further includes generating, in a third portion of the GUI, a third graphical element that is based on the reflection seismic data and the well structural data. In embodiments, an alteration of the first graphical element or the second graphical element results in a concurrent alteration of the third graphical element. Other embodiments may be described or claimed.

Abstract: A method for determining a pressure profile in a subterranean formation is described. The method includes drilling a wellbore in the subterranean formation; lowering a logging tool into the wellbore to measure resistivity values as a function of depth along the wellbore; identifying a plurality of porous zones from the wellbore based on petrophysical logs; converting the measured resistivity values to an amount of total dissolved solids for each of the plurality of identified porous zones; converting the amount of total dissolved solids to a pore fluid density; calculating a pressure based on a sum of the pore fluid densities derived along a length of the well; and generating a depth-based pressure profile.

Abstract: A method of subsurface sequestration of CO2 in a subsurface formation, the method including: producing formation water and hydrocarbons from a first well located within the first region while concurrently injecting an aqueous CO2 solution into a second well located within the second region, wherein the subsurface formation comprises a first region and a second region, the first region and the second region being fluidly connected, and the second region is at a greater depth than the first region and comprises at least one of the subsurface sequestration locations; and allowing the aqueous CO2 solution to sink as a negatively buoyant fluid below the formation water and the hydrocarbons, thereby sequestering the CO2 in the second region of the subsurface formation and wherein the aqueous CO2 solution has a greater density than the formation water and the hydrocarbons, making the aqueous CO2 solution negatively buoyant in the subsurface formation.

Abstract: A method of subsurface sequestration of CO2 in a subsurface formation, the method including: identifying one or more subsurface sequestration locations in the subsurface formation, wherein the subsurface formation includes a first region, a second region, a first well located within the first region, a second well located within the second region, formation water, and hydrocarbons naturally present in the subsurface formation; producing the formation water and the hydrocarbons from the first well while concurrently injecting an aqueous CO2 solution into the second well; and allowing the aqueous CO2 solution to sink as a negatively buoyant fluid below the subsurface water and hydrocarbons, thereby sequestering the CO2 in the second region of the subsurface formation and wherein the aqueous CO2 solution has a greater density than the formation water and the hydrocarbons, making the aqueous CO2 solution negatively buoyant in the subsurface formation.

Abstract: A method of subsurface sequestration of CO2 in a subsurface formation, the method including: identifying one or more subsurface sequestration locations in the subsurface formation, wherein the subsurface formation includes a first region, a second region, a first well located within the first region, a second well located within the second region, formation water, and hydrocarbons naturally present in the subsurface formation; producing the formation water and the hydrocarbons from the first well while concurrently injecting an aqueous CO2 solution into the second well; and allowing the aqueous CO2 solution to sink as a negatively buoyant fluid below the formation water and hydrocarbons, thereby sequestering the CO2 in the second region of the subsurface formation and wherein the aqueous CO2 solution has a greater density than the formation water and the hydrocarbons, making the aqueous CO2 solution negatively buoyant in the subsurface formation.

Abstract: The invention relates to histone deacetylase (HDAC) biomarkers in multiple myeloma. Specifically, the biomarkers are drug specific, histone deacetylase (HDAC) or HDAC6 biomarker RNAs for multiple myeloma. The invention also relates to a kit for determining the treatment efficiency of a HDAC6 inhibitor, and a kit for identifying a histone deacetylase 6 (HDAC6) inhibitor. The invention further relates to a method for monitoring treatment efficiency of an HDAC inhibitor in a subject.

Abstract: Systems and methods include a computer-implemented method for determining and storing a length scale dimension in spatial coordinate systems. A mapping of three-dimensional (3D) grid locations (x,y,z) relative to a continuous surface of the Earth is determined. The 3D grid locations have a grid point spacing in an (x,y) space defining map view coordinates of the continuous surface independent of an elevation z. A length scale (l) is determined for each 3D location. The length scale defines a 3D distance between 3D grid locations, and also defines a structural or geometrical length scale at the 3D location relevant to a given task. Then, (x,y,z,l) information is stored for each 3D grid location. The (x,y,z,l) information defines, for each (x,y) coordinate, a z-coordinate defining an elevation of the continuous surface at the (x,y) coordinate and the local length scale at the (x,y,z) coordinate.

Abstract: Systems and methods include a computer-implemented method includes concurrently outputting, by a computing device to a display of the computing device, a graphical time-domain interpretation of seismic data, a graphical velocity model related to the seismic data, and a graphical depth-domain interpretation of the seismic data. The method may further include identifying, by the computing device, a first alteration to one of the time-domain interpretation, the velocity model, and the depth-domain interpretation. The method may further include identifying, by the computing device based on the first alteration, a second alteration to another of the time-domain interpretation, the velocity model, and the depth-domain interpretation. The method may further include updating, by the computing device based on the first alteration and the second alteration, at least two of the graphical time-domain interpretation, the graphical velocity model, and the graphical depth-domain interpretation.

Abstract: The present disclosure relates to a pharmaceutical combination comprising (a) a histone deacetylase 6 inhibitor and (b) a programmed death ligand 1 (PD-L1) inhibitor, including combined preparations and pharmaceutical compositions thereof; uses of such combination in the treatment or prevention of cancer; and methods of treating or preventing cancer in a subject comprising administering a therapeutically effective amount of such combination.

Abstract: A computer-implemented method for well location optimization for high inclination complex well trajectories includes calculating a thickness of a target geological layer with respect to a planned intersection angle between wellbores and the target geological layer, wherein the target geological layer comprises a known complex geology. A sensitivity of the wellbores is calculated based on reservoir parameters derived from the calculated thickness of the target geological layer at the planned intersection angle. A least sensitive wellbore is selected from the wellbores, wherein the least sensitive wellbore of the wellbores has a lowest uncertainty in geological layer orientation and wellbore orientation.

Abstract: Methods and systems, including computer programs encoded on a computer storage medium can be used for adaptive multi-scale geological modeling and well integration. The systems and methods are used to integrate seismic mapping data and well data for a subsurface region that includes a reservoir. The specification describes an example algorithm that is used to adaptively identify and isolate natural length scales in a seismic map. The identified natural length scales are then used to determine appropriate filtering of well information and ultimately achieve an automatic integration of orientation information from seismic map and well information.

Abstract: A method and a system for sequestering carbon dioxide (CO2) while producing freshwater are provided. An exemplary method includes producing saline water from a saline aquifer, desalinating at least a portion of the saline water, producing freshwater and waste brine, mixing waste CO2 with the waste brine forming a brine/CO2 mixture, and injecting the brine/CO2 mixture into the saline aquifer.

Abstract: A process for drilling a well into a subsurface formation includes receiving data representing depth maps for a given subsurface region, each depth map being generated from seismic data acquired in a seismic survey at a subsurface region. The process includes determining, for depth maps of the plurality, respective weight values; generating data representing a combination of the depth maps based on the respective weight values; generating a cumulative distribution function (CDF) for a particular location in the subsurface region based on the data representing a combination of the depth maps; determining, based on the CDF for that particular location, a probability value representing a depth at which a geological layer occurs in the subsurface region at the particular location; and drilling the well into the subsurface formation at the particular location to a target depth based on the probability value.

Abstract: In accordance with one or more embodiments of the present disclosure, a method of subsurface sequestration of CO2 in a geological basin includes identifying one or more subsurface sequestration locations in the geological basin and injecting an aqueous CO2 solution to be sequestered into the geological basin. The one or more subsurface sequestration locations are regions of deeper geological structure, relative to an adjacent shallower geological structure, into which a negatively buoyant fluid injected into the basin will sink. The aqueous CO2 solution comprises a density that is greater than the density of the water naturally present in the geological basin, such that the injected aqueous CO2 solution pools in the one or more subsurface sequestration locations.

Abstract: Systems and methods include a method used in drilling wells. A three-dimensional (3D) uncertainty cube is generated for a subsurface geological structure containing a well target for drilling operations of a well. The 3D uncertainty cube defines an uncertainty of a geological position relative to a 3D structural model. The 3D uncertainty cube is dynamically updated in real time while drilling the well, including parameterizing the 3D uncertainty cube for a distance ahead of a drill bit. A probability that the well target will be hit is determined using the 3D uncertainty cube. The drilling operations of the well are dynamically re-planned and re-steered based on the updated 3D uncertainty cube, including updating a direction of the drilling operations of the well using the 3D uncertainty cube and the probability. Drilling and acquiring new information are continued to iteratively continue dynamic updates and continued drilling.

Abstract: A method for determining a pressure profile in a subterranean formation is described. The method includes drilling a wellbore in the subterranean formation; lowering a logging tool into the wellbore to measure resistivity values as a function of depth along the wellbore; identifying a plurality of porous zones from the wellbore based on petrophysical logs; converting the measured resistivity values to an amount of total dissolved solids for each of the plurality of identified porous zones; converting the amount of total dissolved solids to a pore fluid density; calculating a pressure based on a sum of the pore fluid densities derived along a length of the well; and generating a depth-based pressure profile.

Abstract: A process for drilling a well into a subsurface formation includes receiving data representing depth maps for a given subsurface region, each depth map being generated from seismic data acquired in a seismic survey at a subsurface region. The process includes determining, for depth maps of the plurality, respective weight values; generating data representing a combination of the depth maps based on the respective weight values; generating a cumulative distribution function (CDF) for a particular location in the subsurface region based on the data representing a combination of the depth maps; determining, based on the CDF for that particular location, a probability value representing a depth at which a geological layer occurs in the subsurface region at the particular location; and drilling the well into the subsurface formation at the particular location to a target depth based on the probability value.