Abstract: Disclosed herein are kinase inhibitory compounds, such as a receptor-interacting protein-1 (RIP1) kinase inhibitor compounds, as well as pharmaceutical compositions and combinations comprising such inhibitory compounds. The compounds may have a structure according to Formula I The disclosed compounds, pharmaceutical compositions, and/or combinations may be used to treat or prevent a kinase-associated disease or condition, particularly a RIP1-associated disease or condition.

Abstract: The invention relates to cartridges for thin layer chromatography (TLC) which hermetically seal the TLC mobile phase during loading, performance of the TLC process, and analysis of the chromatogram. It further relates to associated methods of use—for example for detecting or quantifying an analyte in a sample. It further relates to processes for assembling the cartridge, to associated equipment adapted for use with them, and kits of parts.

Abstract: A deployable mine clearance device is provided and comprises one or more blade members that are movable from a stowed position to a deployed position.

Abstract: Disclosed herein are kinase inhibitory compounds, such as a receptor-interacting protein-1 (RIP1) kinase inhibitor compounds, as well as pharmaceutical compositions and combinations comprising such inhibitory compounds. The disclosed compounds, pharmaceutical compositions, and/or combinations may be used to treat or prevent a kinase-associated disease or condition, particularly a RIP1-associated disease or condition.

Abstract: An article of footwear includes an upper and a sole structure attached to the upper. The sole structure includes a frame attached to the upper with frame exterior and interior surfaces defining a frame internal cavity. The sole structure further includes a midsole member disposed within the frame internal cavity and that is formed via a supercritical foaming process. A lattice-work structure of the frame is formed by a plurality of apertures extending through the frame exterior and interior surfaces such that at least some portions of the upper and the midsole member adjacent the frame interior surface are exposed through the plurality of apertures.

Abstract: A fluid release system for a fuel cell comprises a conduit for communicating water from the fuel cell to one or more outlets; and, a water discharge arrangement arranged to selectively release water from the one or more outlets, wherein the water discharge arrangement is arranged to controllably open the one or more outlets to selectively release water from the one or more outlets.

Abstract: A nozzle for an electrochemical machining device. The nozzle defining a body with first and second releasably attachable body portions forming an electrolyte cavity therebetween, when the first and second body portions are attached. The body includes an inlet port upstream of the cavity, and an outlet port for dispensing a jet of electrolyte towards a surface of a workpiece, in use, where a flow path is defined from the inlet port through the cavity to the outlet port.

Abstract: Various embodiments provide for determining redundant logic in a circuit design based on one or more enable conditions of clock gates, which can be part of electronic design automation (EDA). In particular, some embodiments use one or more enable conditions (of the clock gates) with a satisfiability solver to determine redundant logic coupled to clock circuit elements gated by the clock gates.

Abstract: The invention relates to an interactive headphone system for storing and playing audio content comprising an NFC tag with an RFID code that contains a distinctive identification of the NFC tag, and headphones that comprise a memory that stores one or more audio files, where each of the one or more audio files is associated with a distinctive identification, where the one or more audio files are locked so that access is possible only with an RFID code containing a distinctive identification corresponding to the distinctive identification of a respective audio file, and an NFC reader, where, when the NFC tag having a distinctive identification corresponding to the distinctive identification of a respective audio file is brought into the immediate vicinity of the NFC reader, the headphones are configured to: process the RFID code containing the distinctive identification of the NFC tag; correlate the distinctive identification of the NFC tag with the distinctive identification of the audio file stored on the mem

Abstract: An article of footwear includes an upper having a fastening mechanism, a sole, and a frame having an exterior surface and an interior surface. The sole includes a midsole structure and an outsole structure. The interior surface of the frame is adjacent portions of the midsole structure, the outsole structure, and the upper. The frame further has a lattice-work structure formed by a plurality of apertures extending through the interior and exterior surfaces of the frame such that at least some of the portions of the midsole structure, the outsole structure, and the upper adjacent the interior surface of the frame are exposed through the plurality of apertures. The fastening mechanism includes a fastening member extending through at least one aperture of the plurality of apertures of the frame.

Abstract: The present disclosure relates to a motor drive system comprising: a fuel cell; a motor, electrically connected to the fuel cell; and, a cryogenic system arranged to contain a cryogen, wherein the fuel cell is arranged to output current to the motor, and wherein the cryogenic system is arranged to communicate a cryogen from the cryogenic system to the fuel cell.

Abstract: Various embodiments provide for determining clock gates for decloning based on simulation and a satisfiability solver, which can be part of electronic design automation (EDA). In particular, some embodiments use a simulation process to quickly determine whether enable signals associated with two clock gates are logically equivalent using a random input vector to a circuit design and, if logically equivalent by the simulation process, use a satisfiability solver to determine a variable assignment (e.g., at least one vector) such that the enable signals are found to be non-equivalent.

Abstract: A multi-source aircraft propulsion arrangement comprises a cryogenic propulsion source and a combustion propulsion source wherein the cryogenic propulsion source and the combustion propulsion source may be selectively and independently operated to generate propulsive force for an aircraft.

Abstract: A biofeedback rehabilitation display for gait training visible to the subject including a plurality of foot placement targets visible to the subject on the display and moving along the display at a speed proportional to the desired gait speed of the subject and in a direction along the display representative of the direction of locomotion of the subject; a pair of subject foot icons visible to the subject illustrating real-time foot positioning of the subject throughout the gait pattern of the subject, wherein the foot icons distinguish between stance phase and swing phase throughout the gait pattern of the subject; and at least one real-time proximity measurement visible to the subject for each stance phase providing the subject with an indication of the proximity of each stance phase of each foot with an intended foot placement target.

Abstract: An optically readable marker includes data to be extracted; and an identifier arranged to identify a location of the data to be extracted. The identifier includes a plurality of dots arranged in a set pattern, the dots being small compared to the size of the data to be extracted. The identifier may be used on a beverage container, and/or for augmented reality applications.

Abstract: A biofeedback rehabilitation display for gait training visible to the subject including a plurality of foot placement targets visible to the subject on the display and moving along the display at a speed proportional to the desired gait speed of the subject and in a direction along the display representative of the direction of locomotion of the subject; a pair of subject foot icons visible to the subject illustrating real-time foot positioning of the subject throughout the gait pattern of the subject, wherein the foot icons distinguish between stance phase and swing phase throughout the gait pattern of the subject; and at least one real-time proximity measurement visible to the subject for each stance phase providing the subject with an indication of the proximity of each stance phase of each foot with an intended foot placement target.