Abstract: The present invention relates to compositions and co-crystals each comprising a compound of formula I having the structure: wherein each of R1 and R2 is H or 2H and a co-crystal former selected from adipic acid, citric acid, fumaric acid, maleic acid, succinic acid, or benzoic acid. Also within the scope of this invention are methods of making and using the same.

Abstract: The invention relates to a method for dissolving the components of gel forming materials suitable for use in wound care comprising the steps of admixing said components with an ionic liquid. The ionic liquid may be selected from the group of tertiary amine N-oxides, N,N-dimethyl formamide/nitrogen tetroxide mixtures, dimethyl sulphoxide/paraformaldehyde mixtures and solutions of limium chloride in N,N-dimethyl acetamide or N-methyl pyrrolidone.

Abstract: The present invention relates to compositions and co-crystals each comprising a compound of formula I having the structure: wherein each of R1 and R2 is H or 2H and a co-crystal former selected from adipic acid, citric acid, fumaric acid, maleic acid, succinic acid, or benzoic acid. Also within the scope of this invention are methods of making and using the same.

Abstract: The present invention relates to compositions and co-crystals each comprising a compound of formula I having the structure: wherein each of R1 and R2 is H or 2H and a co-crystal former selected from adipic acid, citric acid, fumaric acid, maleic acid, succinic acid, or benzoic acid. Also within the scope of this invention are methods of making and using the same.

Abstract: Polymorphic forms of Compound (1) or a pharmaceutically acceptable salt thereof, wherein Compound (1) is represented by the following structural formula: are Form A of HCl salt of Compound (1).½H2O, Form F of HCl salt of Compound (1).3H2O, Form D of HCl salt of Compound (1), Form A of Compound (1), and Form A of tosylate salt of Compound (1). Such polymorphic forms are employed for treating influenza, inhibiting the replication of influenza viruses, or reducing the amount of influenza viruses in a biological sample or in a subject.

Abstract: The present invention relates to compositions and co-crystals each comprising a compound of formula I having the structure: wherein each of R1 and R2 is H or 2H and a co-crystal former selected from adipic acid, citric acid, fumaric acid, maleic acid, succinic acid, or benzoic acid. Also within the scope of this invention are methods of making and using the same.

Abstract: The present disclosure provides an optical sensing apparatus for measuring a change in a first property. The optical sensing apparatus comprises first and second optical fibre portions and a sensing region for exposing both the first and second optical fibre portions to a change in an applied force. The force is, or is related to, the first property and has a component that is transversal to the optical fibre portions. The apparatus further comprises a holder for holding the first and second optical fibre portions in the sensing region. The first and second optical fibre portions are arranged relative to each other such that the change in the force results in a first change of an optical property of the first optical fibre portion and in a second change of the optical property of the second optical fibre portion and wherein the first change differs from the second change.

Abstract: Polymorphic forms of Compound (1) or a pharmaceutically acceptable salt thereof, wherein Compound (1) is represented by the following structural formula: are Form A of HCl salt of Compound (1).½H2O, Form F of HCl salt of Compound (1).3H2O, Form D of HCl salt of Compound (1), Form A of Compound (1), and Form A of tosylate salt of Compound (1). Such polymorphic forms are employed for treating influenza, inhibiting the replication of influenza viruses, or reducing the amount of influenza viruses in a biological sample or in a subject.

Abstract: The invention relates to a method for dissolving the components of gel forming materials suitable for use in wound care comprising the steps of admixing said components with an ionic liquid. The ionic liquid may be selected from the group of tertiary amine N-oxides, N,N-dimethyl formamide/nitrogen tetroxide mixtures, dimethyl sulphoxide/paraformaldehyde mixtures and solutions of limium chloride in N,N-dimethyl acetamide or N-methyl pyrrolidone.

Abstract: Provided, in one embodiment, is a vacuum wound dressing for covering a wound bed comprising: a wound contact layer comprising a fibrous blend or fibrous material that forms a cohesive gel when wetted by wound exudate; a source of vacuum situated to be separated from the wound bed by the wound contact layer; and a vacuum sealing layer covering the wound contact layer and adapted to retain relative vacuum in the wound contact layer, wherein (i) the dressing is essentially missing a non-gelling, foam layer in which the source of vacuum is situated or (ii) the vacuum sealing layer comprises as an outer layer a foam layer.

Abstract: The invention relates to a method for dissolving the components of gel forming materials suitable for use in wound care comprising the steps of admixing said components with an ionic liquid. The ionic liquid may be selected from the group of tertiary amine N-oxides, N,N-dimethyl formamide/nitrogen tetroxide mixtures, dimethyl sulphoxide/paraformaldehyde mixtures and solutions of limium chloride in N,N-dimethyl acetamide or N-methyl pyrrolidone.

Abstract: A gas meter comprises a conduit for passage of a gas flow and an ionizer to ionize the gas flow. A modulating electrode structure downstream of the ionizer modulates the ion distribution in the ionized gas flow. A first and a second electrode structure downstream of the modulating electrode structure detect the ion distribution in the ionized gas flow. The modulating electrode structure and the detecting electrode structure can generate an electrical field parallel to the direction of the gas flow. The modulating electrode structure and the detecting electrode structures can each have apertures defined therein for passage of the gas flow. The modulating electrode structure can capture ions of one polarity to generate an ionized gas flow comprising a majority of ions of the opposite polarity. Movement of the ionized gas flow generates a current indicative of the ion distribution between the electrode and the charge source.

Abstract: A method of measuring chlorine concentration of a solution comprising making a first measurement of transmission of ultraviolet light at a selected wavelength through a first sample of said solution at a first temperature; making a second measurement of the transmission of ultraviolet light at said selected wavelength through a second sample of said solution at a second temperature, said second temperature being different than said first temperature; and determining the chlorine concentration in said solution using the results of said first and second measurements.

Abstract: Provided, in one embodiment, is a vacuum wound dressing for covering a wound bed comprising: a wound contact layer comprising a fibrous blend or fibrous material that forms a cohesive gel when wetted by wound exudate; a source of vacuum situated to be separated from the wound bed by the wound contact layer; and a vacuum sealing layer covering the wound contact layer and adapted to retain relative vacuum in the wound contact layer, wherein (i) the dressing is essentially missing a non-gelling, foam layer in which the source of vacuum is situated or (ii) the vacuum sealing layer comprises as an outer layer a foam layer.

Abstract: A gas meter gas a conduit for passage of a gas flow; an ioniser arranged to ionise the gas flow in the conduit; a modulating electrode structure arranged for modulating the ion distribution in the ionised gas flow; and at least a detecting electrode structure downstream of the modulating electrode structure arranged for detecting the modulated ion distribution in the ionised gas flow. The modulating electrode structure is arranged downstream of the ioniser and is configured to generate an electrical field which is substantial in a parallel to the direction of the gas flow.

Abstract: Provided, in one embodiment, is a vacuum wound dressing for covering a wound bed comprising: a wound contact layer comprising a fibrous blend or fibrous material that forms a cohesive gel when wetted by wound exudate; a source of vacuum situated to be separated from the wound bed by the wound contact layer; and a vacuum sealing layer covering the wound contact layer and adapted to retain relative vacuum in the wound contact layer, wherein (i) the dressing is essentially missing a non-gelling, foam layer in which the source of vacuum is situated or (ii) the vacuum sealing layer comprises as an outer layer a foam layer.

Abstract: Many of those having diabetes take a combination of slow and fast acting types of insulin. It is important that the different forms of medicament do not become confused. To this end, a medicament cartridge is provided comprising a sleeve having a bottleneck providing a flange at a first end, a fluid impermeable membrane secured across the first end by a metal cap beaded beneath the flange, and a displaceable piston located internally of the sleeve towards a second end of the sleeve, a collar located against an external periphery of the cartridge housing beneath the flange and an adaptor top press fit over the cap and the collar, the adaptor top being provided with means to act upon the collar thereby to retain the adaptor top on the sleeve.

Abstract: A gas meter comprises a conduit (1) for passage of a gas flow A and an ioniser (2) arranged to ionise the gas flow in the conduit (1). A modulating electrode structure (4) downstream of the ioniser modulates the ion distribution in the ionised gas flow. A first detecting electrode structure (8) and a second electrode structure (9) downstream of the modulating electrode structure 4 detect the modulated ion distribution in the ionised gas flow. The modulating electrode structure (4) and the detecting electrode structures (8, 9) can be configured to generate an electrical field having at least a substantial component parallel to the direction of the gas flow. The modulating electrode structure (4) and the detecting electrode structures (8, 9) can comprise a pair of electrodes (5, 6, 10, 11), each having a plurality of apertures defined therein for passage of the gas flow.

Abstract: The invention relates to a method for dissolving the components of gel forming materials suitable for use in wound care comprising the steps of admixing said components with an ionic liquid. The ionic liquid may be selected from the group of tertiary amine N-oxides, N,N-dimethyl formamide/nitrogen tetroxide mixtures, dimethyl sulphoxide/paraformaldehyde mixtures and solutions of limium chloride in N,N-dimethyl acetamide or N-methylpyrrolidone.

Abstract: A method of measuring the free chlorine level in a solution of chlorinated pool/spa water comprises a first sample of said solution having a first selected pH and a second sample of said solution having a second selected pH and determining first and second ultraviolet light (UV) transmissivity values for each of the first and second samples. The first and second transmissivity values are then used to determine the free chlorine level.