Patents by Inventor Simon Adrian Johnson

Simon Adrian Johnson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chemical synthesis of a chiral oxazinone
    Patent number: 5668280
    Abstract: The present invention provides a process for the preparation of substantially pure N-benzyl-3-(S)-(4-fluorophenyl)-1,4-oxazin-2-one which comprises:(i) contacting racemic N-benzyl-3-(4-fluorophenyl)-1,4-oxazin-2-one with (-)-3-bromocamphor-8-sulphonic acid (hereinafter referred to as (-)-3-BCS) in the presence of a racemising agent;(ii) collecting the resultant crystalline (-)-3-BCS salt of N-benzyl-3-(S)-(4-fluorophenyl)-1,4-oxazin-2-one; and(iii) liberating the free base of N-benzyl-3-(S)-(4-fluorophenyl)-1,4-oxazin-2-one by treatment of the (-)-3-BCS salt collected in step (ii) with aqueous base.
    Type: Grant
    Filed: May 23, 1996
    Date of Patent: September 16, 1997
    Assignee: Merck Sharp & Dohme Limited
    Inventors: Ramon John Alabaster, Ian Frank Cottrell, Andrew William Gibson, Simon Adrian Johnson