Abstract: The present application generally relates to several processes for the preparation of (6R,10S)-10-{4-[5-chloro-2-(4-chloro-1H-1,2,3-triazol-1-yl)phenyl]-6-oxo-1(6H)-pyrimidinyl}-1-(difluoromethyl)-6-methyl-1,4,7,8,9,10-hexahydro-11,15-(metheno)pyrazolo[4,3-b][1,7]diazacyclotetradecin-5(6H)-one: Compound (I).

Abstract: Disclosed is a process for the preparation of certain intermediates, e.g. the following compound: which intermediate and processes are useful in the preparation of a BTK inhibitor, such as ibrutinib.

Abstract: Disclosed is a process for the preparation of certain intermediates, e.g. a process R for preparing a compound of formula (I) wherein, R1, R2 and X1 are as defined in the description, and which intermediate and processes are useful in the preparation of a BTK inhibitor, such as ibrutinib.

Abstract: Highly efficient methods are provided for preparing key intermediates in the synthesis of Compound (I), which are broadly applicable and can provide selected components having a variety of substituents groups.

Abstract: A motor-transmission arrangement for an adjusting device for adjusting two components adjustable relative to each other can include a planetary gear system having a planetary carrier, a planetary gear with planetary gear toothing and which is rotatably mounted in the planetary carrier and with a ring gear with an internal toothing which engages with the planetary gear toothing. An electric motor can have a motor shaft which can be rotated about a motor shaft axis, which shaft interacts with the planetary gear system, and a housing which is closed with first and second housing covers in which the motor shaft is mounted via a first bearing section and a second bearing section.

Abstract: A bearing assembly for supporting a helical-wheel shaft of a helical planetary gear, in particular an adjustment device in vehicles for adjusting two mutually adjustable vehicle parts, wherein the helical-wheel planetary gear is a helical-wheel shaft with a helical-gear toothing, which shaft is rotatably mounted about a helical-wheel shaft axis, and a planetary carrier comprising at least three helical planetary gears, each rotatably mounted in the planetary carrier about a planetary gear axis, and each having a planetary gear toothing, wherein the helical gear planetary axes extend obliquely to the helical-wheel shaft axis, and the bearing assembly for supporting the helical gear shaft has a first bearing section and a second bearing section, wherein the first bearing section consists of an axial and radial bearing, and the second bearing section consists of helical-wheel planetary gears, wherein the planetary gear toothing in the second bearing section meshes with the helical-gear toothing.

Abstract: A helical planetary gear for a helical planetary gear unit for an adjusting device in vehicles for adjusting two components which are adjustable with respect to one another, wherein the helical planetary gear defines a planetary gear axis and comprises planetary gear toothing having a first planetary gear toothing end and a second planetary gear toothing end, wherein the first planetary gear toothing end and the second planetary gear toothing end are arranged apart from one another in relation to the planetary gear axis, and the planetary gear toothing has a diameter that increases or decreases proceeding from the first planetary gear toothing end to the second planetary gear toothing end and further relates to an internal helical gear for a helical planetary gear unit as well as a helical planetary gear unit for an adjusting unit for adjusting two components which are adjustable with respect to one another.

Abstract: A planet carrier for supporting at least one planet wheel in a planetary gear for an adjustment unit for adjusting two components adjustable in relation to one another. The planet wheel comprises a planet wheel axle, which has first and second axle portions protruding beyond the planet wheel, and the planet carrier comprises a tubular main body with a passage that penetrates the main body, first and second support portions originating from the passage, where the first and second support portions are designed for the rotational accommodation of the first and the second axle portions. The planet carrier can include protrusions that fix the first and the second axle portions in the support portions.

Abstract: A pinion cage for supporting at least one spiral gear planet wheel in a spiral gear planetary gear train for an adjustment device for adjusting two structural components which can be adjusted relative to one another, wherein the spiral gear planet wheel comprises a planet wheel axle which comprises a first axial section extending over the spiral gear planet wheel and comprises a second axial section extending over the spiral gear planet wheel, and the pinion cage comprises a tubular base body which defines a pinion cage axis, at least one perforation arranged in the base body and penetrating through it, a first support section starting from the perforation, a second support section starting from the perforation, wherein the first and the second support sections are constructed for rotatably receiving the first and the second axial sections and are arranged in such a manner that the planet wheel axle runs in a twisted manner to the pinion cage axis if the axial sections are received in the support sections, an

Abstract: A motor-transmission arrangement in particular for an adjustment device in vehicles for adjusting two vehicle parts which can be adjusted relative to one another can include a planetary transmission with at least one pinion cage, at least one planet wheel which is rotatably supported in the pinion cage and with a planet wheel cogging, and with at least one hollow gear with an inside cogging which is engaged with the planet wheel cogging, and an electromotor with a motor shaft which can rotate about a motor shaft axle and which comprises a motor shaft cogging arranged directly on the motor shaft, which cogging is engaged with the planet wheel cogging. The disclosure also relates to an adjustment device with such a motor-transmission arrangement and to the usage of such a motor-transmission arrangement in adjustment devices.

Abstract: A motor-transmission arrangement for an adjusting device for adjusting two components adjustable relative to each other can include a planetary gear system having a planetary carrier, a planetary gear with planetary gear toothing and which is rotatably mounted in the planetary carrier and with a ring gear with an internal toothing which engages with the planetary gear toothing. An electric motor can have a motor shaft which can be rotated about a motor shaft axis, which shaft interacts with the planetary gear system, and a housing which is closed with first and second housing covers in which the motor shaft is mounted viaa first bearing section and a second bearing section.

Abstract: A bearing assembly for supporting a helical-wheel shaft of a helical planetary gear, in particular an adjustment device in vehicles for adjusting two mutually adjustable vehicle parts, wherein the helical-wheel planetary gear is a helical-wheel shaft with a helical-gear toothing, which shaft is rotatably mounted about a helical-wheel shaft axis, and a planetary carrier comprising at least three helical planetary gears, each rotatably mounted in the planetary carrier about a planetary gear axis, and each having a planetary gear toothing, wherein the helical gear planetary axes extend obliquely to the helical-wheel shaft axis, and the bearing assembly for supporting the helical gear shaft has a first bearing section and a second bearing section, wherein the first bearing section consists of an axial and radial bearing, and the second bearing section consists of helical-wheel planetary gears, wherein the planetary gear toothing in the second bearing section meshes with the helical-gear toothing.

Abstract: A helical planetary gear for a helical planetary gear unit for an adjusting device in vehicles for adjusting two components which are adjustable with respect to one another, wherein the helical planetary gear defines a planetary gear axis and comprises planetary gear toothing having a first planetary gear toothing end and a second planetary gear toothing end, wherein the first planetary gear toothing end and the second planetary gear toothing end are arranged apart from one another in relation to the planetary gear axis, and the planetary gear toothing has a diameter that increases or decreases proceeding from the first planetary gear toothing end to the second planetary gear toothing end and further relates to an internal helical gear for a helical planetary gear unit as well as a helical planetary gear unit for an adjusting unit for adjusting two components which are adjustable with respect to one another.

Abstract: A pinion cage for supporting at least one spiral gear planet wheel in a spiral gear planetary gear train for an adjustment device for adjusting two structural components which can be adjusted relative to one another, wherein the spiral gear planet wheel comprises a planet wheel axle which comprises a first axial section extending over the spiral gear planet wheel and comprises a second axial section extending over the spiral gear planet wheel, and the pinion cage comprises a tubular base body which defines a pinion cage axis, at least one perforation arranged in the base body and penetrating through it, a first support section starting from the perforation, a second support section starting from the perforation, wherein the first and the second support sections are constructed for rotatably receiving the first and the second axial sections and are arranged in such a manner that the planet wheel axle runs in a twisted manner to the pinion cage axis if the axial sections are received in the support sections, an

Abstract: A planet carrier for supporting at least one planet wheel in a planetary gear for an adjustment unit for adjusting two components adjustable in relation to one another. The planet wheel comprises a planet wheel axle, which has first and second axle portions protruding beyond the planet wheel, and the planet carrier comprises a tubular main body with a passage that penetrates the main body, first and second support portions originating from the passage, where the first and second support portions are designed for the rotational accommodation of the first and the second axle portions. The planet carrier can include protrusions that fix the first and the second axle portions in the support portions.

Abstract: One embodiment of the present invention relates to a printed circuit board comprising one inner metal layer sandwiched between a first and a second insulating layers, wherein the inner metal layer is structured to comprise a conductive path and a bond pad, wherein the first insulating layer includes a recess for receiving an integrated device, wherein the bond pad of the inner metal layer is located in the recess.