Patents by Inventor Simon Albert WAGSCHAL

Simon Albert WAGSCHAL has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthetic options towards the manufacture of (6R,10S)-10-{4-[5-chloro-2-(4-chloro-1H-1,2,3-triazol-1-yl)phenyl]-6-oxo-1(6H)-pyrimidinyl} - 1-(difluoromethyl)-6-methyl-1,4,7,8,9,10-hexahydro-11,15-(metheno)pyrazolo[4,3-b][1,7]diazacyclotetradecin-5(6H)-one
    Patent number: 12378246
    Abstract: Highly efficient methods are provided for preparing key intermediates in the synthesis of Compound (I), which are broadly applicable and can provide selected components having a variety of substituents groups.
    Type: Grant
    Filed: April 10, 2020
    Date of Patent: August 5, 2025
    Assignees: Bristol-Myers Squibb Company, Janssen Pharmaceutica NV
    Inventors: Nicolas Cuniere, Yu Fan, Sergei Kolotuchin, Subha Mukherjee, Eric M. Simmons, Amarjit Singh, Carolyn S. Wei, Yi Xiao, Changxia Yuan, Bin Zheng, Simon Albert Wagschal, Diego Fernando Domenico Broggini, Duy Chi Trung Cao, Kostiantyn Chernichenko, Sebastien Francois Emmanuel Lemaire, Cyril Ben Haïm
  • Processes and intermediates for preparing a Btk inhibitor
    Patent number: 12358917
    Abstract: Disclosed is a process for the preparation of certain intermediates, e.g. the following compound: which intermediate and processes are useful in the preparation of a BTK inhibitor, such as ibrutinib.
    Type: Grant
    Filed: April 13, 2022
    Date of Patent: July 15, 2025
    Assignee: Janssen Pharmaceutica NV
    Inventors: Cyril Ben Haim, Thomas Joost Martti Michiels, Florian Damien Medina, Simon Albert Wagschal, Dominique Paul M. Depré
  • Processes and intermediates for preparing a Btk inhibitor
    Patent number: 12215110
    Abstract: Disclosed is a process for the preparation of certain intermediates, e.g. a process for preparing a compound of formula (I) wherein, R1, R2 and X1 are as defined in the description, and which intermediate and processes are useful in the preparation of a BTK inhibitor, such as ibrutinib.
    Type: Grant
    Filed: May 20, 2020
    Date of Patent: February 4, 2025
    Assignee: Janssen Pharmaceutica NV
    Inventors: Philip James Pye, Andras Horvath, Cheng Yi Chen, Yuanyuan Yuan, Jinxiong Su, Shuo Wang, Simon Albert Wagschal
  • PROCESS TOWARD THE MANUFACTURE OF (6R,10S)-10-{4-[5-CHLORO-2-(4-CHLORO-1H-1,2,3-TRIAZOL-1-YL)PHENYL]-6-OXO-1(6H)-PYRIMIDINYL}- 1-(DIFLUOROMETHYL)-6-METHYL-1,4,7,8,9,10-HEXAHYDRO-11,15-(METHENO)PYRAZOLO[4,3-B][1,7]DIAZACYCLOTETRADECIN-5(6H)-ONE
    Publication number: 20230416252
    Abstract: The present application generally relates to several processes for the preparation of (6R,10S)-10-{4-[5-chloro-2-(4-chloro-1H-1,2,3-triazol-1-yl)phenyl]-6-oxo-1(6H)-pyrimidinyl}-1-(difluoromethyl)-6-methyl-1,4,7,8,9,10-hexahydro-11,15-(metheno)pyrazolo[4,3-b][1,7]diazacyclotetradecin-5(6H)-one: Compound (I).
    Type: Application
    Filed: October 11, 2021
    Publication date: December 28, 2023
    Inventors: Subha MUKHERJEE, William P. GALLAGHER, Christopher Robert JAMISON, Carolyn S. WEI, Sergei KOLOTUCHIN, Amarjit SINGH, Nicolas CUNIERE, Chris SFOUGGATAKIS, Adrian ORTIZ, Steven R. WISNIEWSKI, Bin ZHENG, Helen Y. LUO, Sébastien François Emmanuel LEMAIRE, Cyril BEN HAÏM, Kostiantyn CHERNICHENKO, Diego Fernando Domenico BROGGINI, Simon Albert WAGSCHAL, Duy Chi Trung CAO, Karl REUTER, Björn SCHMALZBAUER, Philipp KOSCHKER, Martin D. EASTGATE, Dimitri SKLIAR, Alexander ZHDANKO, Christos XIOURAS, Matthew Penfield MOWER, Ngoc Duc TRAN, Ramdane RAHMANI, Xavier Jean-Marie JUSSEAU, Kiran MATCHA, Luca Alessandro PEREGO
  • PROCESSES AND INTERMEDIATES FOR PREPARING A BTK INHIBITOR
    Publication number: 20230107573
    Abstract: Disclosed is a process for the preparation of certain intermediates, e.g. the following compound: which intermediate and processes are useful in the preparation of a BTK inhibitor, such as ibrutinib.
    Type: Application
    Filed: April 13, 2022
    Publication date: April 6, 2023
    Inventors: Cyril Ben Haim, Thomas Joost Martti Michiels, Florian Damien Medina, Simon Albert Wagschal, Dominique Paul M. Depré
  • PROCESSES AND INTERMEDIATES FOR PREPARING A BTK INHIBITOR
    Publication number: 20220204516
    Abstract: Disclosed is a process for the preparation of certain intermediates, e.g. a process R for preparing a compound of formula (I) wherein, R1, R2 and X1 are as defined in the description, and which intermediate and processes are useful in the preparation of a BTK inhibitor, such as ibrutinib.
    Type: Application
    Filed: May 20, 2020
    Publication date: June 30, 2022
    Inventors: Philip James PYE, Andras HORVATH, Cheng Yi CHEN, Yuanyuan Yuan, Jinxiong SU, Shuo WANG, Simon Albert WAGSCHAL
  • NOVEL SYNTHETIC OPTIONS TOWARDS THE MANUFACTURE OF (6R,10S)-10-{4-[5-CHLORO-2-(4-CHLORO-1H-1,2,3-TRIAZOL-1-YL)PHENYL]-6-OXO-1(6H)-PYRIMIDINYL}- 1-(DIFLUOROMETHYL)-6-METHYL-1,4,7,8,9,10-HEXAHYDRO-11,15-(METHENO)PYRAZOLO[4,3-B][1,7]DIAZACYCLOTETRADECIN-5(6H)-ONE
    Publication number: 20220144836
    Abstract: Highly efficient methods are provided for preparing key intermediates in the synthesis of Compound (I), which are broadly applicable and can provide selected components having a variety of substituents groups.
    Type: Application
    Filed: April 10, 2020
    Publication date: May 12, 2022
    Inventors: Nicolas CUNIERE, Yu FAN, Sergei KOLUTUCHIN, Subha MUKHERJEE, Eric M. SIMMONS, Amarjit SINGH, Carolyn S. WEI, Yi XIAO, Changxia YUAN, Bin ZHENG, Simon Albert WAGSCHAL, Diego Fernando Domenico BROGGINI, Duy Chi Trung CAO, Kostiantyn CHERNICHENKO, Sebastien Francois Emmanuel LEMAIRE, Cyril BEN HAÏM