Abstract: The present invention includes compounds and compositions, and methods of use thereof for modulating an RNA transcript, or a precursor, isoform, fragment, or mutant thereof by degradation of the RNA transcript via recruitment or binding of one or more decay factors (e.g. an RNA binding protein). The invention also provides methods of preparing such compounds and compositions and methods of treating an RNA-mediated disease, disorder, or condition, comprising administering an effective amount of a disclosed compound or composition to a patient in need thereof. The present invention further provides compositions comprising an RNA binder and a ligand of an RNA-binding protein (RBP), as well as methods of use thereof, including for modulating the activity of an RNA transcript or a precursor, isoform, fragment, or mutant thereof, and treating diseases associated with the same.

Abstract: This disclosure provides compositions and methods for reducing or treating inflammation, e.g., in a subject having an inflammatory condition or disorder.