Abstract: Disclosed are compounds and salts thereof that bind to and modulate cereblon activity. In some embodiments, the binding and modulation of cereblon results in the degradation of IKAROS family zinc finger proteins (e.g., IKZF2).

Abstract: The present invention relates to methods of treating immune disorders and/or inflammation using certain modulator compounds. For example, the present invention provides methods of treating immune and/or inflammatory disorders by administering a composition comprising a compound having the structure of Formula (I).

Abstract: A solar light system may include a solar panel module adapted for converting solar light into electric power. The solar light system may include a splitter cable adapted for connecting electrically and mechanically to the solar panel module, the splitter cable comprising a main power cable connecting to the solar panel module, and at least two downstream cables coupled to the main power cable, each comprising a connection terminal adapted for connecting electrically and mechanically to a lighting device to be powered therethrough, wherein the connection terminals feature a securing part designed for interfacing with a coupling component into a weatherproof connection.

Abstract: Disclosed are compounds and salts thereof that bind to and modulate cereblon activity. In some embodiments, the binding and modulation of cereblon results in the degradation of IKAROS family zinc finger proteins (e.g., IKZF2).

Abstract: The present invention relates to methods of treating immune disorders and/or inflammation using certain modulator compounds. For example, the present invention provides methods of treating immune and/or inflammatory disorders by administering a composition comprising a compound having the structure of Formula (I).

Abstract: Described herein are composition of ascarosides, methods of using them, and the like for inhibiting bacterial population growth or for altering the relative ratio of sub-populations of first and second bacteria in a mixed population of bacteria. The invention is particularly useful, for example, for modifying a microbiome of a patient (e.g., for treatment of gut microbiome dysfunction).

Abstract: The present invention relates to methods of treating immune disorders and/or inflammation using certain modulator compounds. For example, the present invention provides methods of treating immune and/or inflammatory disorders by administering a composition comprising a compound having the structure of Formula (I).

Abstract: The present disclosure relates generally to compounds that are inhibitors of CD73 and are useful in treating CD73-associated diseases or conditions. Compositions containing the compounds of the present disclosure are also provided.

Abstract: Disclosed are compounds that arc inhibitors of CD73 and arc useful in treating CD73-associated diseases or conditions, and compositions containing the compounds.

Abstract: An exterior light operable with a remote comprises a light panel assembly, a motion detector for detecting movement in an area of the exterior light and a control panel comprising controls for selecting a mode of operation of the exterior light. The exterior light comprises a housing enclosing a battery powering the light panel assembly. Modes of operations of the exterior light comprise a time duration and conditions in which the battery is used to power the exterior light panel assembly upon the motion detector sensing movement. A remote control allows to override the mode of operation from the control panel for a given period.

Abstract: A mounting adaptor for an electric light fixture to be mounted on a surface. The mounting adaptor comprising: a base and a joining member each having an interfacing face and an electrical interface, one of the base and the joining member comprising on its interfacing face a groove, the other one of the base and the joining member comprising on its interfacing face a lip adapted to cooperate with the groove thereby providing a capability to assemble releasably the joining member with the base; a locking mechanism adapted to lock the base and the joining member in a mounted position relatively to each other; the base comprising a mounting element adapted to mount the base to the surface; and the joining member comprising a joint element adapted to mount the electric light fixture to the joining member.

Abstract: A mounting adaptor for an electric light fixture to be mounted on a surface. The mounting adaptor comprising: a base and a joining member each having an interfacing face, one of the base and the joining member comprising on its interfacing face a groove, the other one of the base and the joining member comprising on its interfacing face a lip adapted to cooperate with the groove thereby providing a capability to assemble releasably the joining member with the base; a locking mechanism adapted to lock the base and the joining member in a mounted position relatively to each other; the base comprising a mounting element adapted to mount the base to the surface; and the joining member comprising a joint element adapted to mount the electric light fixture to the joining member.

Abstract: A mounting adaptor for an electric light fixture to be mounted on a surface. The mounting adaptor comprising: a base and a joining member each having an interfacing face and an electrical interface, one of the base and the joining member comprising on its interfacing face a groove, the other one of the base and the joining member comprising on its interfacing face a lip adapted to cooperate with the groove thereby providing a capability to assemble releasably the joining member with the base; a locking mechanism adapted to lock the base and the joining member in a mounted position relatively to each other; the base comprising a mounting element adapted to mount the base to the surface; and the joining member comprising a joint element adapted to mount the electric light fixture to the joining member.

Abstract: A mounting adaptor for an electric light fixture to be mounted on a surface. The mounting adaptor comprising: a base and a joining member each having an interfacing face, one of the base and the joining member comprising on its interfacing face a groove, the other one of the base and the joining member comprising on its interfacing face a lip adapted to cooperate with the groove thereby providing a capability to assemble releasably the joining member with the base; a locking mechanism adapted to lock the base and the joining member in a mounted position relatively to each other; the base comprising a mounting element adapted to mount the base to the surface; and the joining member comprising a joint element adapted to mount the electric light fixture to the joining member.

Abstract: The invention relates to compounds of formula (?) as further defined herein and to the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to the uses thereof. The compounds and salts of the present invention inhibit anaplastic lymphoma kinase (ALK) and/or EML4-ALK and are useful for treating or ameliorating abnormal cell proliferative disorders, such as cancer.

Abstract: The invention relates to compounds of formula (?) as further defined herein and to the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to the uses thereof. The compounds and salts of the present invention inhibit anaplastic lymphoma kinase (ALK) and/or EML4-ALK and are useful for treating or ameliorating abnormal cell proliferative disorders, such as cancer.

Abstract: The invention relates to compounds of formula (?) as further defined herein and to the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to the uses thereof. The compounds and salts of the present invention inhibit anaplastic lymphoma kinase (ALK) and/or EML4-ALK and are useful for treating or ameliorating abnormal cell proliferative disorders, such as cancer.

Abstract: The invention relates to compounds of formula (?) as further defined herein and to the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to the uses thereof. The compounds and salts of the present invention inhibit anaplastic lymphoma kinase (ALK) and/or EML4-ALK and are useful for treating or ameliorating abnormal cell proliferative disorders, such as cancer.

Abstract: The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt or solvate thereof, wherein: Ring A is (4-12)-membered heterocyclyl; Ring B is a fused benzene ring selected from the group consisting of: Ring A, ring B, ring C, R1, R1a, R2, R3, R4, L2, n, t, w, and z are as defined in the specification. The invention also relates to pharmaceutical compositions comprising the compounds of formula (I) and methods of treating a condition that is mediated by the modulation of glucokinase, the method comprising administering to a mammal an effective amount of a compound of formula (I).