Patents by Inventor Simon Brack
Simon Brack has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250101123Abstract: Provided herein are anti-LTBR multispecific binding molecules, nucleic acids encoding the anti-LTBR multispecific binding molecules, vectors comprising the nucleic acids, host cells comprising the vectors, and pharmaceutical compositions comprising the anti-LTBR multispecific binding molecules. Also provided are methods of treating cancer in a subject in need thereof, the methods comprising administering the pharmaceutical compositions disclosed herein.Type: ApplicationFiled: December 6, 2024Publication date: March 27, 2025Applicant: Cilag GmbH InternationalInventors: Matthew LORENZI, Sylvie LAQUERRE, Simon BRACK, Kristina KLUPSCH, Babette SCHADE, Vanessa BAERISWYL, Michela SILACCI MELKKO, Julian BERTSCHINGER
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Patent number: 11858556Abstract: A hood assembly for an agricultural vehicle such as a farm tractor has a first hood panel and a second hood panel pivotably attached to the first hood panel and movable from a first closed position to a second open position relative to the first hood panel. The first hood panel is an elongate body mounted above an engine of the vehicle and having a front end and a rear end joined by two side portions. The second hood panel wraps around the front end of the first hood panel and extends along the two sides thereof to respective pivotal attachments. The attachments have a common pivot axis which traverses the first hood panel in spaced-apart relation to the first hood panel front end. Opening the second hood panel provides maintenance access to a cooling package of the vehicle without opening or disassembling the remainder of the hood assembly.Type: GrantFiled: December 23, 2021Date of Patent: January 2, 2024Assignee: AGCO International GmbHInventors: Markus Bräutigam, Andreas Kleinhenz, Franz Erhard, Thomas Maier, Simon Brack
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Publication number: 20220204092Abstract: A hood assembly for an agricultural vehicle such as a farm tractor has a first hood panel and a second hood panel pivotably attached to the first hood panel and movable from a first closed position to a second open position relative to the first hood panel. The first hood panel is an elongate body mounted above an engine of the vehicle and having a front end and a rear end joined by two side portions. The second hood panel wraps around the front end of the first hood panel and extends along the two sides thereof to respective pivotal attachments. The attachments have a common pivot axis which traverses the first hood panel in spaced-apart relation to the first hood panel front end. Opening the second hood panel provides maintenance access to a cooling package of the vehicle without opening or disassembling the remainder of the hood assembly.Type: ApplicationFiled: December 23, 2021Publication date: June 30, 2022Inventors: Markus Bräutigam, Andreas Kleinhenz, Franz Erhard, Thomas Maier, Simon Brack
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Publication number: 20210188990Abstract: Provided herein are anti-LTBR multispecific binding molecules, nucleic acids encoding the anti-LTBR multispecific binding molecules, vectors comprising the nucleic acids, host cells comprising the vectors, and pharmaceutical compositions comprising the anti-LTBR multispecific binding molecules. Also provided are methods of treating cancer in a subject in need thereof, the methods comprising administering the pharmaceutical compositions disclosed herein.Type: ApplicationFiled: December 10, 2020Publication date: June 24, 2021Inventors: Matthew LORENZI, Sylvie LAQUERRE, Simon BRACK, Kristina KLUPSCH, Babette SCHADE, Vanessa BAERISWYL, Michela SILACCI MELKKO, Julian BERTSCHINGER
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Patent number: 10717470Abstract: A vehicle chassis arrangement, preferably for use in an agricultural tractor. The chassis has two frame elements and a differential housing, where the ends of the frame elements are connected to the side of the differential housing facing the rear of the vehicle. A tank cover is attached adjacent to that side of the differential housing, to define a fluid storage tank between the tank cover and the surface of the differential housing.Type: GrantFiled: January 22, 2018Date of Patent: July 21, 2020Assignee: AGCO International GmbHInventors: Markus Braeutigam, Simon Brack
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Publication number: 20190153096Abstract: Advantageous bispecific binding molecules that comprise a CD3 binding and a CD33 binding part are provided. The CD3 binding part comprises an antibody that has variations in the Fc region with reduced binding to C1q and Fc gamma receptors. The bispecific binding molecules can be used in the treatment of cancer.Type: ApplicationFiled: September 25, 2018Publication date: May 23, 2019Applicant: Covagen AGInventors: Simon Brack, Kristina Klupsch, Isabella Attinger-Toller, Fabian Buller, Adrian Zumsteg, Julian Bertschinger, Dragan Grabulovski, Vanessa Baeriswyl, Joana Roquette, Roland Scholz, Roger Santimaria, David Senn, Elena Kage, Clara Albani
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Publication number: 20190100587Abstract: Antibody and other Fc-containing molecules with variations in the Fc region with reduced binding to C1q and Fc gamma receptors are provided, which can be used in the treatment of various diseases and disorders.Type: ApplicationFiled: September 24, 2018Publication date: April 4, 2019Applicant: Covagen AGInventors: Simon Brack, Isabella Attinger-Toller, Fabian Buller, Dragan Grabulovski, Julian Bertschinger, Adrian Zumsteg
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Patent number: 10144277Abstract: A vehicle tank having an upper surface for mounting a fan and radiator to which is sloped between the fan and radiator mounting parts so that there is a difference in the relative height of the parts. The tank also has a horizontal lower surface that abuts the chassis or frame of a vehicle and the space between the upper and lower surfaces holds a fluid.Type: GrantFiled: September 1, 2017Date of Patent: December 4, 2018Assignee: AGCO International GmbHInventors: Markus Braeutigam, Simon Brack
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Publication number: 20180222529Abstract: A vehicle chassis arrangement, preferably for use in an agricultural tractor. The chassis has two frame elements and a differential housing, where the ends of the frame elements are connected to the side of the differential housing facing the rear of the vehicle. A tank cover is attached adjacent to that side of the differential housing, to define a fluid storage tank between the tank cover and the surface of the differential housing.Type: ApplicationFiled: January 22, 2018Publication date: August 9, 2018Inventors: Markus BRAEUTIGAM, Simon BRACK
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Publication number: 20180065470Abstract: A vehicle tank having an upper surface for mounting a fan and radiator to which is sloped between the fan and radiator mounting parts so that there is a difference in the relative height of the parts. The tank also has a horizontal lower surface that abuts the chassis or frame of a vehicle and the space between the upper and lower surfaces holds a fluid.Type: ApplicationFiled: September 1, 2017Publication date: March 8, 2018Inventors: Markus Braeutigam, Simon Brack
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Patent number: 9593314Abstract: The present invention relates to a binding molecule that specifically binds to two different epitopes of an antigen expressed on tumor cells, wherein the binding molecule comprises: (a) a first binding (poly)peptide that specifically binds to a first epitope of said antigen expressed on tumor cells, wherein said first binding (poly)peptide is a Fyn SH3-derived polypeptide; and (b) a second binding (poly)peptide that specifically binds to a second epitope of said antigen expressed on tumor cells. The present invention further relates to a nucleic acid molecule encoding the binding molecule of the invention, a vector comprising said nucleic acid molecule as well as a host cell or a non-human host transformed with said vector. The invention further relates to a method of producing a binding molecule of the invention as well as to pharmaceutical and diagnostic composition.Type: GrantFiled: March 8, 2013Date of Patent: March 14, 2017Assignee: Covagen AGInventors: Simon Brack, Frédéric Mourlane, Isabella Toller, Richard Woods, Julian Bertschinger, Dragan Grabulovski, Babette Schade, Kristina Klupsch, Helen Hachemi
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Patent number: 9085760Abstract: The present invention relates to a polypeptide binding to a chymase (EC 3.4.21.Type: GrantFiled: April 24, 2012Date of Patent: July 21, 2015Assignee: COVAGEN AGInventors: Simon Brack, Sarah Batey, Dragan Grabulovski, Julian Bertschinger, Daniel Schlatter, Jörg Benz, David Banner, Michael Hennig
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Publication number: 20150047065Abstract: The present invention relates to a binding molecule that specifically binds to two different epitopes of an antigen expressed on tumor cells, wherein the binding molecule comprises: (a) a first binding (poly)peptide that specifically binds to a first epitope of said antigen expressed on tumor cells, wherein said first binding (poly)peptide is a Fyn SH3-derived polypeptide; and (b) a second binding (poly)peptide that specifically binds to a second epitope of said antigen expressed on tumor cells. The present invention further relates to a nucleic acid molecule encoding the binding molecule of the invention, a vector comprising said nucleic acid molecule as well as a host cell or a non-human host transformed with said vector. The invention further relates to a method of producing a binding molecule of the invention as well as to pharmaceutical and diagnostic composition.Type: ApplicationFiled: March 8, 2013Publication date: February 12, 2015Inventors: Simon Brack, Frédéric Mourlane, Isabella Toller, Richard Woods, Julian Bertschinger, Dragan Grabulovski, Babette Schade, Kristina Klupsch, Helen Hachemi
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Publication number: 20140162936Abstract: The present invention relates to a polypeptide binding to a chymase (EC 3, 4, 21,39), wherein the polypeptide comprises or consists of an amino acid sequence selected from the group consisting of: (a) GVTLFVALYDY(X1)A(X2)(X3)(X4)(X5) (X6)LSFHKGEKFQIL(X7 (X8)(X9)(X10) (X11)(X12)G(X13)(X14)WEARSLTTGETGYIPSNYVAPVDSIQ (SEQ ID NO: 1), wherein (X1) is R, N, Q, E, K, H, S, T, C, or D; (X2) is E, T, D, Q, L, P, A, S, C, M, N, E, G, A, V or I; (X3) is R, T, H, N, K, S, C, N or Q; (X4) is S, W, T, C, N, Q, For Y; (X5) is T, H, L, F, C, S, M, N, Q, R, K, G, A, V, I, P, Y or W; (X6) is D, Q, H, E, S, T, C, N, R or K; (X7) is D, N, R, E, Q, S, T, C, K or D; (X8) is M, W, G, F, A, S, T, C, S, N, Q, Y, V, L, I or P; (X9) is T, H, S, D, C, N, Q, R, K, E or absent; (X10) is V, T, Q, G, A, L, I, P, S, C, M, N or absent; (X11) is P, A, D, G, K, V, L, I, E, R, M, H or absent; (X12) is N, V, P, I, E, T, S, A, G, L, C, M, Q or D; (X13) is D, E, T, P, G, A, V, L, I, S, C, M, N or Q, and (X14) is W, Y, L, G, A, V, I, P, M, or F; (b)Type: ApplicationFiled: April 24, 2012Publication date: June 12, 2014Applicant: COVAGEN AGInventors: Simon Brack, Sarah Batey, Dragan Grabulovski, Julian Bertschinger, Daniel Schlatter, Jörg Benz, David Banner, Michael Hennig
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Patent number: 7968685Abstract: Specific binding members against extracellular matrix protein tenascin-C, especially scFv antibody molecules against domain A1, domain C and domain D of tenascin-C. Anti-tenascin-C specific binding members conjugated with labels, cytotoxic molecules or cytokines. Use of anti-tenascin-C specific binding members in diagnosis and treatment, especially of cancer.Type: GrantFiled: October 31, 2005Date of Patent: June 28, 2011Assignee: Philogen S.p.A.Inventors: Simon Brack, Michela Silacci, Dario Neri
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Publication number: 20080056997Abstract: Specific binding members against extracellular matrix protein tenascin-C, especially scFv antibody molecules against domain A1, domain C and domain D of tenascin-C. Anti-tenascin-C specific binding members conjugated with labels, cytotoxic molecules or cytokines. Use of anti-tenascin-C specific binding members in diagnosis and treatment, especially of cancer.Type: ApplicationFiled: October 31, 2005Publication date: March 6, 2008Applicant: PHILOGEN S.P.A.Inventors: Simon Brack, Michela Silacci, Dario Neri