Patents by Inventor Simon BREITLER

Simon BREITLER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of GalNAc oligonucleotide conjugates
    Patent number: 11339187
    Abstract: The invention comprises a process for the preparation of GalNAc oligonucleotide conjugates which comprises the coupling of a GalNAc cluster compound of the formula or corresponding salts, enantiomers and/or a stereoisomer thereof, with an oligonucleotide in the presence of an O-dicarboximidouronium salt as coupling agent.
    Type: Grant
    Filed: July 27, 2020
    Date of Patent: May 24, 2022
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Simon Breitler
  • Process for GalNAc oligonucleotide conjugates
    Patent number: 11021503
    Abstract: The invention comprises a process for the preparation of therapeutically valuable GalNAc cluster oligonucleotide conjugates. The process comprises the coupling of an alkali metal salt, earth alkali metal salt or a tetraalkylammonium salt of an oligonucleotide with a GalNAc cluster compound or with a salt thereof and a subsequent purification.
    Type: Grant
    Filed: November 21, 2019
    Date of Patent: June 1, 2021
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Simon Breitler, Joerg Lill, Kurt Puentener, René Trussardi
  • PROCESS FOR THE PREPARATION OF GALNAC OLIGONUCLEOTIDE CONJUGATES
    Publication number: 20200361983
    Abstract: The invention comprises a process for the preparation of GalNAc oligonucleotide conjugates which comprises the coupling of a GalNAc cluster compound of the formula or corresponding salts, enantiomers and/or a stereoisomer thereof, with an oligonucleotide in the presence of an O-dicarboximidouronium salt as coupling agent.
    Type: Application
    Filed: July 27, 2020
    Publication date: November 19, 2020
    Applicant: Hoffmann-La Roche Inc.
    Inventor: SIMON BREITLER
  • PROCESS FOR GALNAC OLIGONUCLEOTIDE CONJUGATES
    Publication number: 20200079807
    Abstract: The invention comprises a process for the preparation of therapeutically valuable GalNAc cluster oligonucleotide conjugates. The process comprises the coupling of an alkali metal salt, earth alkali metal salt or a tetraalkylammonium salt of an oligonucleotide with a GalNAc cluster compound or with a salt thereof and a subsequent purification.
    Type: Application
    Filed: November 21, 2019
    Publication date: March 12, 2020
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Simon BREITLER, Joerg LILL, Kurt PUENTENER, René TRUSSARDI