Patents by Inventor Simon Bushell

Simon Bushell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • AMINOTHIAZOLES AND THEIR USES
    Publication number: 20170015704
    Abstract: The present application describes organic compounds of Formula (I) and pharmaceutical compositions thereof, and their use for the treatment, prevention and/or amelioration of diseases, particularly bacterial infections.
    Type: Application
    Filed: September 22, 2016
    Publication date: January 19, 2017
    Applicant: Novartis AG
    Inventors: Simon Bushell, Matthew J. Lamarche, Jennifer Leeds, Lewis Whitehead
  • Aminothiazoles and their uses
    Patent number: 9492496
    Abstract: The present application describes organic compounds of Formula (I) and pharmaceutical compositions thereof, and their use for the treatment, prevention and/or amelioration of diseases, particularly bacterial infections.
    Type: Grant
    Filed: May 30, 2014
    Date of Patent: November 15, 2016
    Assignee: Novartis AG
    Inventors: Simon Bushell, Matthew J. Lamarche, Jennifer Leeds, Lewis Whitehead
  • AMINOTHIAZOLES AND THEIR USES
    Publication number: 20140315790
    Abstract: The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of diseases.
    Type: Application
    Filed: April 17, 2013
    Publication date: October 23, 2014
    Inventors: Simon Bushell, Matthew J, LaMarche, Michael A. Patane, Lewis Whitehead
  • AMINOTHIAZOLES AND THEIR USES
    Publication number: 20140274878
    Abstract: The present application describes organic compounds of Formula (I) and pharmaceutical compositions thereof, and their use for the treatment, prevention and/or amelioration of diseases, particularly bacterial infections.
    Type: Application
    Filed: May 30, 2014
    Publication date: September 18, 2014
    Applicant: NOVARTIS AG
    Inventors: Simon Bushell, Matthew J. Lamarche, Jennifer Leeds, Lewis Whitehead
  • AMINIOTHIAZOLES AND THEIR USES
    Publication number: 20130231275
    Abstract: The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of diseases particularly bacterial infections.
    Type: Application
    Filed: April 17, 2013
    Publication date: September 5, 2013
    Applicant: Novartis AG
    Inventors: Simon Bushell, Matthew J. Lamarche, Jennifer Leeds, Lewis Whitehead
  • Aminothiazoles and their uses
    Patent number: 8426356
    Abstract: The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of diseases particularly bacterial infections.
    Type: Grant
    Filed: December 12, 2008
    Date of Patent: April 23, 2013
    Assignee: Novartis AG
    Inventors: Simon Bushell, Matthew J. LaMarche, Jennifer Leeds, Lewis Whitehead
  • N-formyl hydroxylamines compounds
    Patent number: 8044199
    Abstract: Novel N-formyl hydroxylamine compounds of formula I: wherein R1 is hydrogen, alkyl, heteroaryl, heterocycloalkyl, aryl, heteroaryl or cycloalkyl; R3 is hydrogen, halogen or alkoxy; R4 is pyridazinyl; n is 0 to 3; and wherein one or more of the ring nitrogen heteroatoms of said pyridazinyl is optionally oxidized and their derivatives are disclosed. These N-formyl hydroxylamine compounds inhibit peptidyl deformylase (PDF), an enzyme present in prokaryotes. The compounds are useful as antimicrobials and antibiotics. The compounds of the invention display selective inhibition of peptidyl deformylase versus other metalloproteinases such as MMPs. Methods of preparation and use of the compounds are also disclosed.
    Type: Grant
    Filed: June 2, 2009
    Date of Patent: October 25, 2011
    Assignee: Vicuron Holdings LLC
    Inventors: Kathryn Rene Bracken, Simon Bushell, Karl Dean, Charles Francavilla, Rakesh K. Jain, Kwangho Lee, Mohindra Seepersaud, Lei Shu, Arathi Sundaram, Zhengyu Yuan
  • EFTU inhibitors or aminothiazoles and their uses
    Patent number: 7851439
    Abstract: Organic compounds that are useful for the treatment, prevention and/or amelioration of diseases are described.
    Type: Grant
    Filed: May 30, 2007
    Date of Patent: December 14, 2010
    Assignee: Novartis AG
    Inventors: Simon Bushell, Matthew LaMarche, Michael J. Patane, Lewis Whitehead
  • AMINOTHIAZOLES AND THEIR USES
    Publication number: 20100267757
    Abstract: The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of diseases.
    Type: Application
    Filed: July 1, 2010
    Publication date: October 21, 2010
    Inventors: Matthew J. LaMarche, Simon Bushell, Michael A. Patane, Lewis Whitehead
  • N-Formyl Hydroxylamines compounds
    Publication number: 20100063278
    Abstract: Novel N-formyl hydroxylamine compounds and their derivatives are discloses. These N-formyl hydroxylamine compounds inhibit peptidyl deformylase (PDF), an enzyme present in prokaryotes. The compounds are useful as antimicrobials and antibiotics. The compounds of the invention display selective inhibition of peptidyl deformylase versus other metalloproteinases such as MMPs. Methods of preparation and use of the compounds are also disclosed.
    Type: Application
    Filed: June 2, 2009
    Publication date: March 11, 2010
    Applicants: Novartis AG, Vicuron Pharmaceuticals, Inc.
    Inventors: Kathryn Rene Bracken, Simon Bushell, Karl Dean, Charles Francavilla, Rakesh K. Jain, Kwangho Lee, Mohindra Seepersaud, Lei Shu, Arathi Sundaram, Zhengyu Yuan
  • N-formyl hydroxylamines
    Patent number: 7615635
    Abstract: Novel N-formyl hydroxylamine compounds and their derivatives are disclosed. These N-formyl hydroxylamine compounds inhibit peptidyl deformylase (PDF), an enzyme present in prokaryotes. The compounds are useful as antimicrobials and antibiotics. The compounds of the invention display selective inhibition of peptidyl deformylase versus other metalloproteinases such as MMPs. Methods of preparation and use of the compounds are also disclosed.
    Type: Grant
    Filed: May 22, 2006
    Date of Patent: November 10, 2009
    Assignees: Novartis AG, Vicuron Pharmaceuticals, Inc.
    Inventors: Kathryn Rene Bracken, Simon Bushell, Karl Dean, Charles Francavilla, Rakesh K. Jain, Kwangho Lee, Mohindra Seepersaud, Lei Shu, Arathi Sundaram, Zhengyu Yuan
  • Aminothiazoles and their Uses
    Publication number: 20090156628
    Abstract: The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of diseases particularly bacterial infections.
    Type: Application
    Filed: December 12, 2008
    Publication date: June 18, 2009
    Inventors: Simon Bushell, Matthew J. LaMarche, Jennifer Leeds, Lewis Whitehead
  • EFTU INHIBITORS OR AMINOTHIAZOLES AND THEIR USES
    Publication number: 20080221142
    Abstract: The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of diseases.
    Type: Application
    Filed: May 30, 2007
    Publication date: September 11, 2008
    Inventors: Matthew J. LaMarche, Simon Bushell, Michael A. Patane, Lewis Whitehead
  • N-Formyl Hydroxylamines
    Publication number: 20080161558
    Abstract: Novel N-formyl hydroxylamine compounds and their derivatives are disclosed. These N-formyl hydroxylamine compounds inhibit peptidyl deformylase (PDF), an enzyme present in prokaryotes. The compounds are useful as antimicrobials and antibiotics. The compounds of the invention display selective inhibition of peptidyl deformylase versus other metalloproteinases such as MMPs. Methods of preparation and use of the compounds are also disclosed.
    Type: Application
    Filed: May 22, 2006
    Publication date: July 3, 2008
    Inventors: Kathryn Rene Bracken, Simon Bushell, Karl Dean, Charles Francavilla, Rakesh K. Jain, Kwangho Lee, Mohindra Seepersaud, Lei Shu, Arathi Sundaram, Zhengyu Yuan