Abstract: The invention relates to a detection arrangement, a detection system comprising said arrangement, and a method of processing data from said arrangement. The detector arrangement disclosed comprises at least one array of detectors, wherein the detectors are configured to detect photons emitted from an object as a result of positron annihilation due to irradiation of the object with photons of a predetermined energy. Each detector in the array is linked to or associated with one or more other detector in the array to define a region of interest (RoI). The detector arrangement comprises or is communicatively coupled to a coincidence trigger unit which is configured to register or determine a coincidence in response to receiving detection signals from two different detectors forming part of the same RoI and indicating detection of substantially back-to-back co-linear and co-incident photons in the RoI.

Abstract: N(57) Abstract: There is a need for new and alternative options for immune therapy of proliferative diseases such as cancer. This need C\11 may be address by providing a chimeric antigen receptor having an extracellular domain including a binding domain which recognises Nthe cancer-stem-cell-associated protein Lgr5; a transmembrane domain; and an intracellular signalling domain that activates a cellular .,, function. Such CAR T cells can be used to kill cancer cells and treat or prevent cancer in a subject.

Abstract: A method of producing graphene or other two-dimensional material such as graphene including heating the substrate held within a reaction chamber to a temperature that is within a decomposition range of a precursor, and that allows two-dimensional crystalline material formation from a species released from the decomposed precursor; establishing a steep temperature gradient (preferably >1000° C. per meter) that extends away from the substrate surface towards an inlet for the precursor; and introducing precursor through the relatively cool inlet and across the temperature gradient towards the substrate surface. The steep temperature gradient ensures that the precursor remains substantially cool until it is proximate the substrate surface thus minimizing decomposition or other reaction of the precursor before it is proximate the substrate surface. The separation between the precursor inlet and the substrate is less than 100 mm.

Abstract: Compounds of Formula (I): and salts thereof, and methods of use as Janus kinase inhibitors are described herein.

Abstract: Compounds of Formula (I) and (II), or a stereoisomer, tautomer, solvate, prodrug or salt thereof, and methods of use as Janus kinase inhibitors are described herein.

Abstract: Compounds and salts thereof that are useful as JAK kinase inhibitors are described herein. Also provided are pharmaceutical compositions that include such a JAK inhibitor and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.

Abstract: Described herein are tetrahydro-pyrido[3,4-b]indol-1-yl compounds with estrogen receptor modulation activity or function having the Formula I structure: and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such estrogen receptor modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

Abstract: A photo-selective light spectrum-modifying net for use in citrus fruit production, the net comprising a woven array of parallel and mutually spaced first threads and an array of parallel and mutually spaced second threads, the second threads being inclined to the first threads to define an array of openings between the first and second threads, wherein the first threads are uncolored and composed of a first polymer which is selected from a polymer incorporating a white pigment or dye, a transparent polymer or a translucent polymer, and the second threads are colored red and composed of a second polymer which incorporates a red pigment or dye, the second threads being adapted to transmit, scatter and reflect electromagnetic radiation in the wavelength range of from 640 to 680 nm. Also disclosed is a method of producing citrus fruit using the net.

Abstract: A method of producing graphene or other two-dimensional material such as graphene including heating the substrate held within a reaction chamber to a temperature that is within a decomposition range of a precursor, and that allows two-dimensional crystalline material formation from a species released from the decomposed precursor; establishing a steep temperature gradient (preferably >1000° C. per meter) that extends away from the substrate surface towards an inlet for the precursor; and introducing precursor through the relatively cool inlet and across the temperature gradient towards the substrate surface. The steep temperature gradient ensures that the precursor remains substantially cool until it is proximate the substrate surface thus minimizing decomposition or other reaction of the precursor before it is proximate the substrate surface. The separation between the precursor inlet and the substrate is less than 100 mm.

Abstract: A method of producing graphene or other two-dimensional material such as graphene including heating the substrate held within a reaction chamber to a temperature that is within a decomposition range of a precursor, and that allows two-dimensional crystalline material formation from a species released from the decomposed precursor; establishing a steep temperature gradient (preferably >1000° C. per meter) that extends away from the substrate surface towards an inlet for the precursor; and introducing precursor through the relatively cool inlet and across the temperature gradient towards the substrate surface. The steep temperature gradient ensures that the precursor remains substantially cool until it is proximate the substrate surface thus minimizing decomposition or other reaction of the precursor before it is proximate the substrate surface. The separation between the precursor inlet and the substrate is less than 100 mm.

Abstract: An artificial reality system is described that renders, presents, and controls user interface elements within an artificial reality environment, and performs actions in response to one or more detected gestures of the user. In one example, an artificial reality system comprises a head-mounted display configured to output artificial reality content; a stylus; a stylus action detector configured to detect movement of the stylus, detect a stylus selection action, and after detecting the stylus selection action, detect further movement of the stylus; a UI engine configured to generate stylus movement content in response to detecting movement of the stylus, and generate a UI input element in response to detecting the stylus selection action; and a rendering engine configured to render the stylus movement content and the UI input element as overlays to the artificial reality content, and update the stylus movement content based on the further movement of the stylus.

Abstract: An artificial reality system is described that renders, presents, and controls user interface elements within an artificial reality environment, and performs actions in response to one or more detected gestures of the user. In one example, an artificial reality system comprises an image capture device configured to capture image data representative of a physical environment; a head-mounted display (HMD) configured to output artificial reality content; a gesture detector configured to identify, from the image data, a gesture comprising a motion of two fingers from a hand to form a pinching configuration and a subsequent pulling motion while in the pinching configuration; a user interface (UI) engine configured to generate a UI input element in response to identifying the gesture; and a rendering engine configured to render the UI input element as an overlay to at least some of the artificial reality content.

Abstract: A fibre drawing method for forming a fibre from a low Young's modulus material.

Abstract: An artificial reality system is described that renders, presents, and controls user interface elements within an artificial reality environment, and performs actions in response to one or more detected gestures of the user. In one example, an artificial reality system comprises an image capture device configured to capture image data representative of a physical environment; a head-mounted display (HMD) configured to output artificial reality content; a gesture detector configured to identify, from the image data, a gesture comprising a motion of two fingers from a hand to form a pinching configuration and a subsequent pulling motion while in the pinching configuration; a user interface (UI) engine configured to generate a UI input element in response to identifying the gesture; and a rendering engine configured to render the UI input element as an overlay to at least some of the artificial reality content.

Abstract: A uranium oxide fuel pellet having an inner region and an outer rim region about the inner region, and that the fuel pellet is cylindrical and the inner region and outer rim region are coaxial cylindrical regions. The outer rim region has an excess of oxygen in comparison to the inner region, wherein high burnup structure (HBS) formation will be suppressed or delayed. Preferably, the excess oxygen is obtained by a chemical treatment by immersing the pellet in hydrogen peroxide (H2O2) or potassium permanganate (KMnO4) in solution.

Abstract: An image sensor may be formed from stacked first and second substrates. An array of imaging pixels and verification circuitry may be formed in the first substrate. Row control circuitry may be formed in the second substrate. The row control circuitry may provide row control signals to the array of imaging pixels. The verification circuitry may also receive the row control signals from the row control circuitry. The first substrate may include a plurality of n-channel metal-oxide semiconductor transistors and may not include any p-channel metal-oxide semiconductor transistors. The verification circuitry may include an SR latch circuit with an S node coupled to a pull-up line and an R node coupled to a pull-down transistor to ensure the SR latch circuit starts up in a set state. The verification circuitry may include a level shifter that shifts a control signal voltage when the control signal is at a low level.

Abstract: The present invention relates to an optimized chimeric antigen receptor (CAR), and genetically modified cells expressing the same, that can target a diverse range of cancer types. More specifically, the CAR has an optimized linker length that facilitates the targeting and lyse of a wide range of cancer cell types by CAR expressing T cells.

Abstract: A method of producing graphene or other two-dimensional material such as graphene including heating the substrate held within a reaction chamber to a temperature that is within a decomposition range of a precursor, and that allows two-dimensional crystalline material formation from a species released from the decomposed precursor; establishing a steep temperature gradient (preferably >1000° C. per meter) that extends away from the substrate surface towards an inlet for the precursor; and introducing precursor through the relatively cool inlet and across the temperature gradient towards the substrate surface. The steep temperature gradient ensures that the precursor remains substantially cool until it is proximate the substrate surface thus minimizing decomposition or other reaction of the precursor before it is proximate the substrate surface. The separation between the precursor inlet and the substrate is less than 100 mm.

Abstract: A method of producing graphene or other two-dimensional material such as graphene including heating the substrate held within a reaction chamber to a temperature that is within a decomposition range of a precursor, and that allows two-dimensional crystalline material formation from a species released from the decomposed precursor; establishing a steep temperature gradient (preferably >1000° C. per meter) that extends away from the substrate surface towards an inlet for the precursor; and introducing precursor through the relatively cool inlet and across the temperature gradient towards the substrate surface. The steep temperature gradient ensures that the precursor remains substantially cool until it is proximate the substrate surface thus minimizing decomposition or other reaction of the precursor before it is proximate the substrate surface. The separation between the precursor inlet and the substrate is less than 100 mm.

Abstract: Binding members, e.g. human antibody molecules, which bind interleukin-6 (IL-6) and neutralise its biological effects. Use of binding members for IL-6 in medical treatment e.g. for treating inflammatory diseases and tumours associated with IL-6.