Abstract: Provided is a dietary supplement and method of use that promote skin hydration and thus improve its appearance. The supplement includes a form of hyaluronic acid and at least one ceramide—the hyaluronic acid promoting water retention in the deep layers of the epidermis and the ceramide promoting the surface retention of moisture.

Abstract: Ferroptosis (cell death mediated by iron-dependent lipid peroxide accumulation) results from lipid peroxidation of phospholipids containing polyunsaturated fatty acyl moieties. Glutathione, the key cellular antioxidant capable of inhibiting lipid peroxidation via the activity of the enzyme glutathione peroxidase 4 (GPX-4), is generated directly from the sulfur-containing aminoacid cysteine, and indirectly from methionine via the transsulfuration pathway. Cysteine and methionine deprivation (CMD) in the diet can synergistically increase RSL3-mediated cell death and lipid peroxidation in both murine and human glioma cell lines and in ex-vivo organotypic slice cultures. A cysteine-depleted, methionine-restricted diet can improve survival in an syngeneic orthotopic murine glioma model. This CMD diet leads to profound in-vivo metabolomic, proteomic and lipidomic alterations, leading to improvements in the efficacy of ferroptotic therapies in glioma treatment with a non-invasive dietary modification.

Abstract: The present disclosure provides, inter alia, methods for treating or ameliorating the effects of a cancer in a subject in need thereof by combining a radiosensitizer such as a ferroptosis inducer with radiation. Methods for identifying and treating a subject with a cancer that is resistant to radiotherapy, methods for enhancing the anti-tumor effect of radiation in a subject undergoing radiotherapy, and methods for enhancing the effect of radiation on a cancer cell are also provided.

Abstract: The present disclosure relates to a method, a device and a system for computer game difficulty assessment. The method comprises: recording game data by a data collector in a process of simulating game playing by operating a computer game through an API (Application Programming Interface) of the computer game using an agent algorithm; measuring a goal attainment difficulty of the computer game at this timing according to goal completion degrees of a plurality of goals corresponding to all attempts at each decision-making timing in the recorded game data; measuring a strategy space-related difficulty of the computer game at this timing according to goal completion degrees of a plurality of goals corresponding to all actions at each decision-making timing in the recorded game data; assessing difficulty of the computer game based on a goal attainment difficulty and a strategy space-related difficulty at each timing.

Abstract: The present disclosure relates to a method, a device and a system for computer game difficulty assessment. The method comprises: recording game data by a data collector in a process of simulating game playing by operating a computer game through an API (Application Programming Interface) of the computer game using an agent algorithm; measuring a goal attainment difficulty of the computer game at this timing according to goal completion degrees of a plurality of goals corresponding to all attempts at each decision-making timing in the recorded game data; measuring a strategy space-related difficulty of the computer game at this timing according to goal completion degrees of a plurality of goals corresponding to all actions at each decision-making timing in the recorded game data; assessing difficulty of the computer game based on a goal attainment difficulty and a strategy space-related difficulty at each timing.

Abstract: Methods, apparatus, and other embodiments facilitate transitioning a database between two modes. The two modes include a mode where table information for separate tables in the database is stored in a single monolithic file and a mode where the table information for separate tables is stored in separate files. Conventional attempts to make this type of transition lock the database for an unacceptable amount of time. Example methods and apparatus make a copy of a database that is to be transitioned, lock the copy, make a second instance of the copy, and then perform the work necessary for the transition in the second instance. This allows the original database to remain running. When the second instance is complete, the second instance is synchronized to the original database and then the transition is completed by copying the second instance to the original or failing the original over to the second instance.

Abstract: Methods, apparatus, and other embodiments facilitate transitioning a database between two modes. The two modes include a mode where table information for separate tables in the database is stored in a single monolithic file and a mode where the table information for separate tables is stored in separate files. Conventional attempts to make this type of transition lock the database for an unacceptable amount of time. Example methods and apparatus make a copy of a database that is to be transitioned, lock the copy, make a second instance of the copy, and then perform the work necessary for the transition in the second instance. This allows the original database to remain running. When the second instance is complete, the second instance is synchronized to the original database and then the transition is completed by copying the second instance to the original or failing the original over to the second instance.

Abstract: A method for improving the usability of product feedback data can begin with the receipt of product feedback search parameters by an intelligent product feedback analytics tool. The product feedback search parameters can represent a product or a group of products. Product feedback search results having a rating value and/or textual feedback content can be obtained for the product feedback search parameters. For each product in the search results, a composite rating value can be synthesized from the rating values contained in the search results. For each product in the search results, the product feedback search results can be analyzed for analytic parameters using natural language processing techniques. An analytic parameter can represent a commonality within a subset of the search results. The product feedback search results, composite rating values, and analytic parameters can be presented within a user interface, providing context for the composite rating value.

Abstract: A method for improving the usability of product feedback data can begin with the receipt of product feedback search parameters by an intelligent product feedback analytics tool. The product feedback search parameters can represent a product or a group of products. Product feedback search results having a rating value and/or textual feedback content can be obtained for the product feedback search parameters. For each product in the search results, a composite rating value can be synthesized from the rating values contained in the search results. For each product in the search results, the product feedback search results can be analyzed for analytic parameters using natural language processing techniques. An analytic parameter can represent a commonality within a subset of the search results. The product feedback search results, composite rating values, and analytic parameters can be presented within a user interface, providing context for the composite rating value.

Abstract: A method of initiating contact based upon automatically shared profile data can include a step of automatically and wirelessly exchanging profile information between at least two computing devices. A determination can be made as to whether a contact opportunity exists by comparing received profile information with a set of previously established contact rules. A notification of a contract opportunity can be automatically presented upon one of the computing devices, depending upon whether the profile information favorably compares with the contact rules.

Abstract: In the invention, incorrect authentication information for accessing at least one secured computing asset can be received. A similarity score between the incorrect authentication information and correct authentication information can be determined. One of many different access levels can be assigned to a computing session based upon the similarity score. Access consistent with the assigned access level can be granted. One access level can be an emulation access level that grants access to at least one simulated asset designed to mimic the secured asset. Access to the simulated asset can be provided in a fashion so that a user, who is likely an intruder, is unaware that they are not receiving the secured asset information. A tracking action can be optionally initiated against the intruder. Further, user behavior with the simulated session or a limited access session can be compared against a behavior profile to dynamically increase or decrease session permissions.

Abstract: An electronic commerce method can include the step of determining a plurality of e-commerce partners. For each partner, a partner identifier can be presented within a commerce GUI. In the commerce GUI, the partner identifier can be an expandable node. An expansion of at least one of the nodes can be presented within the commerce GUI. For each expansion, a transaction identifier can be presented as a child node of the expanded node. The transaction identifier can represent an electronic commerce transaction between a user of the commerce GUI and the associated e-commerce partner.

Abstract: A software architecture can include an artifact layer and a configuration layer. The artifact layer can contain multiple application independent artifacts. A configuration layer can contain at least one application. The application can include multiple states in which the application executes instructions. The states can exist within execution spaces that are distributed across a network. The application uses artifacts of the artifact layer, which can operate in a state dependent manner.

Abstract: A method (10) for managing the display of sensitive content in non-trusted environments can include the steps of interrogating (12) a list of policies associated with a given user and a physical device, determining (14) a location of the physical device, comparing (18) the location of the physical device with a list of trusted locations, and enforcing (20) a plurality of rules contained in the policy by limiting or restricting access to sensitive information based on the location.

Abstract: In the invention, incorrect authentication information for accessing at least one secured computing asset can be received. A similarity score between the incorrect authentication information and correct authentication information can be determined. One of many different access levels can be assigned to a computing session based upon the similarity score. Access consistent with the assigned access level can be granted. One access level can be an emulation access level that grants access to at least one simulated asset designed to mimic the secured asset. Access to the simulated asset can be provided in a fashion so that a user, who is likely an intruder, is unaware that they are not receiving the secured asset information. A tracking action can he optionally initiated against the intruder. Further, user behavior with the simulated session or a limited access session can be compared against a behavior profile to dynamically increase or decrease session permissions.

Abstract: A method for managing communications including receiving a multitude of communication attempts from a multitude of communication sources. For each communication attempt, a communication event can be responsively determined. For each communication event, an event weight for the communication event can be determined. Each event weight can be compared to an event threshold associated with the communication event. At least one communication management action can be responsively performed. The communication management action can include a busy indication action, a queuing action, an automated response action, a linking action, a notification action, and/or a reformatting action.

Abstract: A method (10) for managing the display of sensitive content in non-trusted environments can include the steps of interrogating (12) a list of policies associated with a given user and a physical device, determining (14) a location of the physical device, comparing (18) the location of the physical device with a list of trusted locations, and enforcing (20) a plurality of rules contained in the policy by limiting or restricting access to sensitive information based on the location.

Abstract: A method for managing communications including receiving a multitude of communication attempts from a multitude of communication sources. For each communication attempt, a communication event can be responsively determined. For each communication event, an event weight for the communication event can be determined. Each event weight can be compared to an event threshold associated with the communication event. At least one communication management action can be responsively performed. The communication management action can include a busy indication action, a queuing action, an automated response action, a linking action, a notification action, and/or a reformatting action.