Abstract: Provided is a dietary supplement and method of use that promote skin hydration and thus improve its appearance. The supplement includes a form of hyaluronic acid and at least one ceramide—the hyaluronic acid promoting water retention in the deep layers of the epidermis and the ceramide promoting the surface retention of moisture.

Abstract: Ferroptosis (cell death mediated by iron-dependent lipid peroxide accumulation) results from lipid peroxidation of phospholipids containing polyunsaturated fatty acyl moieties. Glutathione, the key cellular antioxidant capable of inhibiting lipid peroxidation via the activity of the enzyme glutathione peroxidase 4 (GPX-4), is generated directly from the sulfur-containing aminoacid cysteine, and indirectly from methionine via the transsulfuration pathway. Cysteine and methionine deprivation (CMD) in the diet can synergistically increase RSL3-mediated cell death and lipid peroxidation in both murine and human glioma cell lines and in ex-vivo organotypic slice cultures. A cysteine-depleted, methionine-restricted diet can improve survival in an syngeneic orthotopic murine glioma model. This CMD diet leads to profound in-vivo metabolomic, proteomic and lipidomic alterations, leading to improvements in the efficacy of ferroptotic therapies in glioma treatment with a non-invasive dietary modification.

Abstract: The present disclosure provides, inter alia, methods for treating or ameliorating the effects of a cancer in a subject in need thereof by combining a radiosensitizer such as a ferroptosis inducer with radiation. Methods for identifying and treating a subject with a cancer that is resistant to radiotherapy, methods for enhancing the anti-tumor effect of radiation in a subject undergoing radiotherapy, and methods for enhancing the effect of radiation on a cancer cell are also provided.

Abstract: Methods, apparatus, and other embodiments facilitate transitioning a database between two modes. The two modes include a mode where table information for separate tables in the database is stored in a single monolithic file and a mode where the table information for separate tables is stored in separate files. Conventional attempts to make this type of transition lock the database for an unacceptable amount of time. Example methods and apparatus make a copy of a database that is to be transitioned, lock the copy, make a second instance of the copy, and then perform the work necessary for the transition in the second instance. This allows the original database to remain running. When the second instance is complete, the second instance is synchronized to the original database and then the transition is completed by copying the second instance to the original or failing the original over to the second instance.

Abstract: Methods, apparatus, and other embodiments facilitate transitioning a database between two modes. The two modes include a mode where table information for separate tables in the database is stored in a single monolithic file and a mode where the table information for separate tables is stored in separate files. Conventional attempts to make this type of transition lock the database for an unacceptable amount of time. Example methods and apparatus make a copy of a database that is to be transitioned, lock the copy, make a second instance of the copy, and then perform the work necessary for the transition in the second instance. This allows the original database to remain running. When the second instance is complete, the second instance is synchronized to the original database and then the transition is completed by copying the second instance to the original or failing the original over to the second instance.