Patents by Inventor Simon Cherniak

Simon Cherniak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of 17-desoxy-corticosteroids
    Patent number: 10112970
    Abstract: The present invention provides an improved process for the preparation of 17-desoxy corticosteroid derivatives in a single chemical step by reacting the 17-hydroxy starting material with an excess of Trimethylsilyl Iodide. The present invention is specifically advantageous in preparing 17-desoxy corticosteroid derivatives having one or more halogen groups at positions 2, 6, 7 or 9 of the corticosteroid such as Clocortolone of Desoximetasone.
    Type: Grant
    Filed: January 9, 2017
    Date of Patent: October 30, 2018
    Assignee: Taro Pharmaceutical Industries Ltd.
    Inventors: Simon Cherniak, Rosa Cyjon, Ilana Ozer, Igor Nudelman
  • PROCESS FOR THE PREPARATION OF 17-DESOXY-CORTICOSTEROIDS
    Publication number: 20170114088
    Abstract: The present invention provides an improved process for the preparation of 17-desoxy corticosteroid derivatives in a single chemical step by reacting the 17-hydroxy starting material with an excess of Trimethylsilyl Iodide. The present invention is specifically advantageous in preparing 17-desoxy corticosteroid derivatives having one or more halogen groups at positions 2, 6, 7 or 9 of the corticosteroid such as Clocortolone of Desoximetasone.
    Type: Application
    Filed: January 9, 2017
    Publication date: April 27, 2017
    Inventors: Simon CHERNIAK, Rosa CYJON, Ilana OZER, Igor NUDELMAN
  • Process for the preparation of 2-phenyl-1,3-propanediol
    Patent number: 9233898
    Abstract: The present invention is related to a novel synthetic procedure that provides a simple, safe and commercially valuable method for the preparation of 2-phenyl-1,3-propanediol. The process for the preparation of 2-phenyl-1,3-propanediol involves reducing diethyl phenylmalonate with sodium borohydride (NaBH4) in the presence of an alkali metal dihydrogen phosphate buffer or the hydrate thereof.
    Type: Grant
    Filed: September 5, 2011
    Date of Patent: January 12, 2016
    Assignee: TARO PHARMACEUTICAL INDUSTRIES LTD.
    Inventors: Daniella Gutman, Wael Baidossi, Sorin Bercovici, Simon Cherniak
  • PROCESS FOR THE PREPARATION OF 2-PHENYL-1,3-PROPANEDIOL
    Publication number: 20130231496
    Abstract: The present invention is related to a novel synthetic procedure that provides a simple, safe and commercially valuable method for the preparation of 2-phenyl-1,3-propanediol. The process for the preparation of 2-phenyl-1,3-propanediol involves reducing diethyl phenylmalonate with sodium borohydride (NaBH4) in the presence of an alkali metal dihydrogen phosphate buffer or the hydrate thereof.
    Type: Application
    Filed: September 5, 2011
    Publication date: September 5, 2013
    Applicant: TARO PHARMACEUTICAL INDUSTRIES LTD.
    Inventors: Daniella Gutman, Wael Baidossi, Sorin Bercovici, Simon Cherniak
  • PROCESS FOR THE PREPARATION OF 17-DESOXY-CORTICOSTEROIDS
    Publication number: 20130211069
    Abstract: The present invention provides an improved process for the preparation of 17-desoxy corticosteroid derivatives in a single chemical step by reacting the 17-hydroxy starting material with an excess of Trimethylsilyl Iodide. The present invention is specifically advantageous in preparing 17-desoxy corticosteroid derivatives having one or more halogen groups at positions 2, 6, 7 or 9 of the corticosteroid such as Clocortolone of Desoximetasone.
    Type: Application
    Filed: July 20, 2011
    Publication date: August 15, 2013
    Applicant: Taro Pharmaceutical Industries Ltd.
    Inventors: Simon Cherniak, Rosa Cyjon, Ilana Ozer, Igor Nudelman