Patents by Inventor Simon Cocklin

Simon Cocklin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TREATING CANCER WITH SMALL MOLECULES THAT INHIBIT ACSS-2
    Publication number: 20250213546
    Abstract: Cancers develop specific metabolic adaptations such as the opportunistic utilization of acetate as an alternative carbon source and the generation of acetyl-CoA mediated by ACSS-2, which is upregulated in response to nutrient and hypoxic stress. This pathway can fuel various processes involving acetyl-CoA, including de novo fatty acid synthesis and protein acetylation. Provided herein are methods of treating a cancerous disease in a subject using compounds that inhibit ACSS-2.
    Type: Application
    Filed: March 30, 2023
    Publication date: July 3, 2025
    Inventors: Alexej DICK, Simon COCKLIN, Adel Ahmed Rashad AHMED, Mauricio J. REGINATO, Lorela CIRAKU, Emily M. ESQUEA
  • Small-Molecule HIV-1 Capsid Protein Inhibitors and Methods Using Same
    Publication number: 20210115061
    Abstract: The present invention provides a method of treating, ameliorating, and/or preventing HIV-I infection in a subject, comprising the step of administering to the subject one or more of the compounds useful within the invention.
    Type: Application
    Filed: June 21, 2019
    Publication date: April 22, 2021
    Inventor: Simon COCKLIN
  • Compositions useful for inhibiting HIV-1 infection and methods using same
    Patent number: 9920073
    Abstract: The present invention includes novel compositions useful for preventing or treating an HIV-1 infection in a subject in need thereof. The present invention further includes a novel method of preventing or treating an HIV-1 infection in a subject in need thereof, the method comprising administering to the subject an effective amount of a compound of the invention. In certain embodiments, the subject is further administered at least one additional therapeutic agent.
    Type: Grant
    Filed: October 3, 2014
    Date of Patent: March 20, 2018
    Assignee: Drexel University
    Inventor: Simon Cocklin
  • NOVEL COMPOSITIONS USEFUL FOR INHIBITING HIV-1 INFECTION AND METHODS USING SAME
    Publication number: 20160214998
    Abstract: The present invention includes novel compounds, and compositions comprising same, useful for preventing or treating an HIV-1 infection in a subject in need thereof. The present invention further includes a novel method of preventing or treating an HIV-1 infection in a subject in need thereof, comprising administering to the subject an effective amount of a compound and/or composition of the invention. In certain embodiments, the subject is further administered at least one additional therapeutic agent.
    Type: Application
    Filed: October 3, 2014
    Publication date: July 28, 2016
    Applicant: Drexel University
    Inventor: Simon Cocklin
  • Small Molecule Modulators of HIV-1 Capsid Stability and Methods Thereof
    Publication number: 20130165489
    Abstract: The present invention includes a method of inhibiting, suppressing or preventing a viral infection in a subject, comprising administering to the subject a pharmaceutical composition comprising one or more of the compounds useful within the invention.
    Type: Application
    Filed: April 25, 2011
    Publication date: June 27, 2013
    Applicants: The Trustees of the University of Pennsylvania, Philadelphia Health & Education Corporation d/b/a Drexel University College of Medicine
    Inventors: Simon Cocklin, Sandhya Kortagere, Amos B. Smith, III
  • Small Molecule Inhibitors of Functions of the HIV-1 Matrix Protein
    Publication number: 20130109698
    Abstract: The present invention includes a method of inhibiting, suppressing or preventing retroviral infection in a subject in need thereof, comprising administering to the subject a pharmaceutical composition comprising one or more of the compounds of the invention.
    Type: Application
    Filed: April 25, 2011
    Publication date: May 2, 2013
    Inventor: Simon Cocklin