Abstract: The apparatus pre-treats fluid and then delivers it to a patient during surgery, for example a hyperthermic intra-peritoneal chemotherapy (HIPEC) procedure. It comprises a reservoir (2) for the fluid, a reversible pump (10) and a valve assembly (22). In a recirculation mode, the pump (10) is operated in one direction to draw fluid from the reservoir (2), through the valve assembly (22) and back to the reservoir (2), while the fluid is pre-treated by heating, for example. In a fluid delivery mode, the pump (10) is operated in an opposite direction to draw fluid from the reservoir (2) and deliver the fluid through the valve assembly (22) to a port (30) from which it can be supplied to the patient. A second pump (12) may be provided for drawing fluid from the patient via a return port (48). The pumps (10,12) may be peristaltic pumps integrated with the walls of the reservoir (2).

Abstract: The disclosure relates to a cell processing unit for cell and gene therapy manufacture comprising a housing defining an enclosure into which a cell processing platform can be mounted, a platform mounting bracket within the housing and configured and arranged to receive and retain a cell processing platform, a drive apparatus configured and arranged to operatively engage and act upon a cell processing platform to move same with respect to the platform mounting bracket, and an actuator configured and arranged to exert a force on a container mounted into the cell processing platform to expel a contents from the container.

Abstract: The present disclosure relates to a cell processing container for use in one or more unit operations in cell and/or gene therapy manufacture, the container having a base section, a top section arranged substantially in parallel with the base section and a wall element arranged between the top section and the base section and defining an internal lumen of the container, in which the wall element of the cell culture container preferably is compressible with respect to the top and base section and the wall element of the cell culture container is composed of a flexible material, wherein the cell processing container comprises at least one sterile connector end configured to operatively couple with a further sterile connector end to form a sterile connector between the cell processing container and a further container to which the cell processing container is to be fluidly connected.

Abstract: The present disclosure relates to a cell processing platform for use in one or more unit operations in cell and/or gene therapy manufacture, the platform comprising a body portion comprising at least one fluid inlet fluidly connected to a fluid outlet, and an auxiliary container port fluidly coupled to the at least one fluid inlet of the body portion, wherein the auxiliary container port is configured and arranged to receive and sealingly engage with an auxiliary container and to fluidly connect the auxiliary container lumen with the at least one fluid inlet of the body portion, and a primary container port configured and arranged to sealingly engage with a primary container and to fluidly connect the primary container lumen with the fluid outlet of the body portion.

Abstract: A cell processing device for use in performing one or more unit processes in one or more of cell or gene therapy manufacturing, comprising a cell processing platform fluidly coupled to at least one auxiliary container and to at least one primary container, the cell processing platform comprising a body portion comprising at least one fluid inlet fluidly connected to a fluid outlet, and an auxiliary container port fluidly coupled to the at least one fluid inlet of the body portion, wherein the at least one auxiliary container is received in sealing engagement with the auxiliary container port such that the auxiliary container lumen is fluidly connected with the at least one fluid inlet of the body portion, and a primary container is received in sealingly engagement with the primary container port such that the primary container lumen is fluidly connected with the fluid outlet of the body portion.

Abstract: An injector pen is provided that includes a cartridge housing 2, a dose selector housing 10 and a nut 18 for coupling the two housings 2,10 together. The dose selector housing 10 defines an intermediate axial position, where the nut 18 can be temporarily retained in the dose selector housing 10 to form a sub-assembly suitable for transport to a different location. During final assembly of the injector pen, the cartridge housing 2 securely engages with the nut 18 and displaces the nut 18 from the intermediate axial position to a final axial position.

Abstract: This invention relates generally to security covers for electrical appliances which are powered by mains electricity. More specifically it relates to security covers to operate the electrical appliances by authorised users locally or remotely via an authorisation device via a network such as the internet. The security cover houses a switch and includes an authorisation device for enabling an authorised person to control a power supply, via the switch, to an electrical device or appliance. The security cover has an input means adapted to receive an authorisation signal; the switch is operative in response to the authorisation signal and a command signal in order to connect and disconnect the power supply to the device or appliance.

Abstract: The disclosure relates to systems, devices and methods for at least one of cell and gene therapy manufacture. In some embodiments, a cell processing unit is provided and comprises a housing defining an enclosure into which a cell processing platform can be mounted, a platform mounting bracket within the housing and configured and arranged to receive and retain a cell processing platform, a drive apparatus configured and arranged to operatively engage and act upon a cell processing platform so as to move same with respect to the platform mounting bracket, and an actuator configured and arranged to exert a force on a container mounted into the cell processing platform so as to expel a contents from the container.

Abstract: This invention relates generally to security covers for electrical appliances which are powered by mains electricity. More specifically it relates to security covers to operate the electrical appliances by authorised users locally or remotely via an authorisation device via a network such as the internet. The security cover houses a switch and includes an authorisation device for enabling an authorised person to control a power supply, via the switch, to an electrical device or appliance. The security cover has an input means adapted to receive an authorisation signal; the switch is operative in response to the authorisation signal and a command signal in order to connect and disconnect the power supply to the device or appliance.

Abstract: An improved restraining device may include a retractable strap lead, a housing in which the retractable strap lead is at least partially housed, and a twister for changing the orientation of the retractable strap so that, in use, the orientation of the strap is changed as it is deployed from the housing.

Abstract: A restraining device for an animal or a child that has a restraint(1), a retractable lead (2) and a housing (4), in which the retractable lead (2) is at least partially housed. The housing (4) is releasably attached to the restraint (1) and has a twister (13) for changing the orientation of the retractable lead (2) as it exits the housing (4).