Patents by Inventor Simon Daniel Spivack

Simon Daniel Spivack has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GC tag-modified bisulfite genomic DNA sequencing for continuous methylation spectra
    Patent number: 7851154
    Abstract: The present invention relates to a tag-modified bisulfite genomic sequencing (tBGS) method developed for simplified evaluation of DNA methylation sites. The method employs direct cycle sequencing of PCR products at kilobase scale, without conventional DNA fragment cloning. The method entails subjecting bisulfite-modified genomic DNA to a second-round PCR amplification employing GC-tagged primers. The invention also relates to a method for identifying a patient at risk for lung cancer using the tBGS technique disclosed.
    Type: Grant
    Filed: July 24, 2006
    Date of Patent: December 14, 2010
    Inventors: Simon Daniel Spivack, James Gordon Herman, Weiguo Han