Abstract: A suspension assembly (10) comprises a support member (12) for supporting an article, an elongate substantially flat strip (14), and a securing arrangement (16). The support member (12) defines an opening (24) through which the strip (14) can be Inserted. The strip (14) defines a plurality of apertures (26). The securing arrangement (16) includes a securing member (18) receivable through a selected one of the apertures (26) in the strip (14) to secure the support member (12) to the strip (14).

Abstract: The present invention relates to the field of testing and evaluation of biological samples and provides an apparatus for cultured samples including at least one independently accessible module adapted for incubating at least one of a number of samples wherein the at least one module is operatively associated with a light source and a movable optical inspection means adapted for motion about a viewing axis through the module to enable a sweeping of viewing area. The invention also provides a method of assessing cultured samples for viability, including the steps of: disposing biological samples in a substantially elliptical arrangement within a culturing chamber of an independently accessible module and imaging individual samples of the substantially elliptical arrangement with optical inspection means driven within an X-Y plane that is normal to a viewing axis through the module to obtain time lapse measurement of development of individual samples.

Abstract: A stiffening assembly (10) for stiffening an article (12) is disclosed. The stiffening assembly comprises a plurality of main modules (14) arrangeable on the article. Each main module comprises a body (16) and a receiving formation (28) on the body for receiving a portion of the article therethrough. The stiffening assembly further includes a fastening arrangement for fastening the main modules to one another. The fastening arrangement comprises first and second fastening formations (24, 26).

Abstract: One aspect of the present disclosure provides antibodies that can act as agonists of PD-1, thereby modulating immune responses regulated by PD-1. Another aspect of the disclosure provides compositions comprising PD-1 specific antibodies and their use in methods of down regulating the immune response. These methods can be practiced on any subject, including humans or animals. Anti-PD-1 antibodies disclosed herein may be used, in another aspect of the invention to detect PD-1 or its fragments in a biological sample. The amount of PD-1 detected may be correlated with the expression level of PD-1, and associated with the activation status of immune cells (e.g., activated T cells, B cells, and/or monocytes) in the subject.

Abstract: An engine shutoff valve is provided which includes a valve body having an air passageway in which a disc assembly and a valve seat assembly are located. The disc assembly includes a disc member which is arranged to be rotated and moved toward the valve seat assembly upon the occurrence of an engine runaway condition to close the valve. The valve seat assembly includes an anti-friction ring which is arranged to be engaged by the disc member when the valve is closed. The anti-friction ring is rotatable with respect to the valve body and the disc member to prevent the disc member from sticking thereto after closure of the valve, whereupon the valve can be readily reopened.

Abstract: The present invention relates to the field of testing and evaluation of biological samples and provides apparatus for cultured samples comprising at least one independently accessible module adapted for incubating at least one of a plurality of samples wherein the at least one module is operatively associated with a light source and a movable optical inspection means adapted for motion about a viewing axis through the module to enable a sweeping of viewing area. The invention also provides a method of assessing cultured samples for viability comprising the steps of: disposing biological samples in a substantially elliptical arrangement within a culturing chamber of an independently accessible module; imaging individual samples of the substantially elliptical arrangement with optical inspection means driven within an X-Y plane that is normal to a viewing axis through the module to obtain time lapse measurement of development of individual samples.

Abstract: One aspect of the present disclosure provides antibodies that can act as agonists of PD-1, thereby modulating immune responses regulated by PD-1. Another aspect of the disclosure provides compositions comprising PD-1 specific antibodies and their use in methods of down regulating the immune response. These methods can be practiced on any subject, including humans or animals. Anti-PD-1 antibodies disclosed herein may be used, in another aspect of the invention, to detect PD-1 or its fragments in a biological sample. The amount of PD-1 detected may be correlated with the expression level of PD-1, and associated with the activation status of immune cells (e.g., activated T cells, B cells, and/or monocytes) in the subject.

Abstract: An engine shutoff valve is provided which includes a valve body having an air passageway in which a disc assembly and a valve seat assembly are located. The disc assembly includes a disc member which is arranged to be rotated and moved toward the valve seat assembly upon the occurrence of an engine runaway condition to close the valve. The valve seat assembly includes an anti-friction ring which is arranged to be engaged by the disc member when the valve is closed. The anti-friction ring is rotatable with respect to the valve body and the disc member to prevent the disc member from sticking thereto after closure of the valve, whereupon the valve can be readily reopened.