Patents by Inventor Simon Dowler

Simon Dowler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polypeptides
    Publication number: 20100047823
    Abstract: The use of polypeptides capable of binding to PtdIns(3,4)P2, PtdIns3P, PtdIns4P or but not capable of binding to PtdIns(3,4,5)P3, in a screening method for identifying a compound suitable for modulating signalling by PtdIns(3,4)P2, PtdIns3P, PtdIns4P or PtdIns(3,5)P2. The polypeptides preferably comprises a PH (pleckstrin homology) domain which binds specifically to one of PtdIns(3,4)P2, PtdIns3P, PtdIns4P or PtdIns(3,5)P2. The PH domain preferably has at least five of the six residues of a Putative PtdIns(3,4,5)P3 Binding Motif (PPBM).
    Type: Application
    Filed: October 5, 2009
    Publication date: February 25, 2010
    Applicant: MEDICAL RESEARCH COUNCIL
    Inventors: Simon Dowler, David Campbell, Alexander Gray, Peter Downes, Dario Alessi
  • Polypeptides
    Publication number: 20040106148
    Abstract: The use of a polypeptide capable of binding to PtdIns(3,4)P2, PtdIns3P, PtdIns4P or PtdIns(3,5)P2 but not capable of binding to PtdIns(3,4,5)P3, in a screening method for identifying a compound suitable for modulating signalling by PtdIns(3,4)P2, PtdIns3P, PtdIns4P or PtdIns(3,5)P2. The polypeptide preferably comprises a PH domain which binds specifically to one of PtdIns(3,4)P2, PtdIns3P, PtdIns4P or PtdIns(3,5)P2. The PH−domain preferably has at least five of the six residues of a PutativePtdIns(3,4,5)P3 Binding Motif (PPBM).
    Type: Application
    Filed: September 5, 2003
    Publication date: June 3, 2004
    Inventors: Simon Dowler, David Campbell, Alexander Gray, Peter Downes, Dario Alessi