Abstract: Provided are methods of treating skin with at least two alternating treatment modalities to improve the health and/or diminish signs of aging. Some methods according to the present invention may comprise topically applying at least two separate compositions, in a sequential, rotating, or alternating fashion to overcome adaptation, tolerance, or sensitization phenomena.

Abstract: Provided are methods of treating skin with at least two alternating treatment modalities to improve the health and/or diminish signs of aging. Some methods according to the present invention may comprise topically applying at least two separate compositions, in a sequential, rotating, or alternating fashion to overcome adaptation, tolerance, or sensitization phenomena.

Abstract: Provided are methods of treating skin with at least two alternating treatment modalities to improve the health and/or diminish signs of aging. Some methods according to the present invention may comprise topically applying at least two separate compositions, in a sequential, rotating, or alternating fashion to overcome adaptation, tolerance, or sensitization phenomena.

Abstract: Provided are methods of treating skin with at least two alternating treatment modalities to improve the health and/or diminish signs of aging. Some methods according to the present invention may comprise topically applying at least two separate compositions, in a sequential, rotating, or alternating fashion to overcome adaptation, tolerance, or sensitization phenomena.

Abstract: Provided are methods of treating skin with at least two alternating treatment modalities to improve the health and/or diminish signs of aging. Some methods according to the present invention may comprise topically applying at least two separate compositions, in a sequential, rotating, or alternating fashion to overcome adaptation, tolerance, or sensitization phenomena.

Abstract: A container having sides with contours that readily and essentially automatically orient the container upon grasping the container. The container may have distinct, discontinuous contours on opposite sides, defining grasping sides of the container. If a dispensing portion is offset from the container's central axis, then upon grasping the container at the distinct contoured grasping sides, the dispensing orifice is automatically positioned at a predetermined orientation with respect to the user's grasping hand. Such contours thus provide a tactile indicator of the orientation of the container, permitting orienting of the container in a user's hand without the need for visual assessment or inspection of the container. The container closure may further be shaped and configured to provide another tactile indicator of the container orientation. For instance, the closure may be asymmetrical. Preferably, such asymmetry is about the axis extending between the container's contoured sides.