Patents by Inventor Simon Ficht

Simon Ficht has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of preparing glycopeptides
    Patent number: 8816050
    Abstract: A method is provided for the synthesis of glycopeptides using a sugar assisted ligation strategy, wherein an N-terminal peptide portion in the form of a thioester is coopled with a C-terminal peptide portion bearing a carbohydrate moiety comprising a thiol group.
    Type: Grant
    Filed: March 22, 2007
    Date of Patent: August 26, 2014
    Inventors: Chi-Huey Wong, Ashraf Brik, Yu-Ying Yang, Simon Ficht, Richard Payne
  • IN VIVO INCORPORATION OF AN UNNATURAL AMINO ACID COMPRISING A 1,2-AMINOTHIOL GROUP
    Publication number: 20110076718
    Abstract: The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate unnatural amino acids that comprise a 1,2 aminothiol group into polypeptides. The invention provides translation systems in which polypeptides comprising unnatural amino acids that comprise a 1,2 aminothiol group can be produced. The invention also provides methods for producing polypeptides containing unnatural amino acids that comprise a 1,2 aminothiol group. Also provided by the invention are compositions comprising orthogonal aminoacyl-tRNA synthetases that preferentially aminoacylate a cognate orthogonal tRNA with unnatural amino acids that comprise a 1,2 aminothiol group. The invention provides methods for the synthesis of the unnatural amino acid 2-amino-3-(4-(2-amino-3-mercaptopropan-amido)phenyl)-propanoic acid.
    Type: Application
    Filed: February 27, 2009
    Publication date: March 31, 2011
    Inventors: Simon Ficht, Michael Jahnz, Jan Grunewald, Stefan Schiller, Peter G. Schultz
  • METHOD OF PREPARING GLYCOPEPTIDES
    Publication number: 20110060121
    Abstract: A method is provided for the synthesis of glycopeptides using a sugar assisted ligation strategy, wherein an N-terminal peptide portion in the form of a thioester is coupled with a C-terminal peptide portion bearing a carbohydrate moiety comprising a thiol group.
    Type: Application
    Filed: March 22, 2007
    Publication date: March 10, 2011
    Applicant: THE SCRIPPS RESEARCH INSTITUTE
    Inventors: Chi-Huey Wong, Ashraf Brik, Yu-Ying Yang, Simon Ficht, Richard Payne